Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition
Increased concentrations of insulin, glucose and glycohemoglobin are associated with Type II diabetes mellitus (DM) and recognized as characteristic markers of the disease; in Alzheimer's (AD), Vascular dementia (VaD), and both dementia's with superimposed diabetes (AD + DM, VaD + DM) the...
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v115_n1_p77_Dominguez http://hdl.handle.net/20.500.12110/paper_03009564_v115_n1_p77_Dominguez |
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paper:paper_03009564_v115_n1_p77_Dominguez2023-06-08T15:27:39Z Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition Marschoff, Enrique R. Alzheimer's disease Dementia risk factors Glucose Glycated hemoglobin Insulin Non-insulin-dependent Type II diabetes mellitus Vascular dementia glucose glycosylated hemoglobin insulin aged Alzheimer disease analysis of variance article comparative study controlled study correlation analysis female glucose blood level hemoglobin blood level human insulin blood level major clinical study male multiinfarct dementia non insulin dependent diabetes mellitus priority journal statistics Aged Alzheimer Disease Blood Glucose Brain Dementia, Vascular Diabetes Mellitus, Type 2 Female Hemoglobin A, Glycosylated Humans Insulin Magnetic Resonance Imaging Male Increased concentrations of insulin, glucose and glycohemoglobin are associated with Type II diabetes mellitus (DM) and recognized as characteristic markers of the disease; in Alzheimer's (AD), Vascular dementia (VaD), and both dementia's with superimposed diabetes (AD + DM, VaD + DM) the knowledge is scarce. The sample (n = 122; males = 60; mean age = 73 ± 7) comprised DM, AD, VaD, AD + DM, and VaD + DM patients, and healthy controls (C). The ANOVA's yielded significant differences between groups: Insulin p = 3.7 × 10 -3; Glucose p < 10-12; Glycohemoglobin p = 9.2×10-4. Comparisons between groups (DM vs. C, AD + DM vs. AD, VaD + DM vs. VaD, and demented DM vs. non-demented DM) resulted significant for all variables (Bonferroni's statistic, α = 0.05). Diabetic and diabetic demented patients presented significant increases largely different from controls (0.01 < p < 0.001), unlike the non-significant changes in their non-diabetic counterparts; linear relationships were found across all groups. The correlation's insulin/glucose and insulin/glycohemoglobin change to positive within demented groups, indicating a different performance of insulin in demented and non-demented subjects. © 2007 Springer-Verlag. Fil:Marschoff, E.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2008 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v115_n1_p77_Dominguez http://hdl.handle.net/20.500.12110/paper_03009564_v115_n1_p77_Dominguez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Alzheimer's disease Dementia risk factors Glucose Glycated hemoglobin Insulin Non-insulin-dependent Type II diabetes mellitus Vascular dementia glucose glycosylated hemoglobin insulin aged Alzheimer disease analysis of variance article comparative study controlled study correlation analysis female glucose blood level hemoglobin blood level human insulin blood level major clinical study male multiinfarct dementia non insulin dependent diabetes mellitus priority journal statistics Aged Alzheimer Disease Blood Glucose Brain Dementia, Vascular Diabetes Mellitus, Type 2 Female Hemoglobin A, Glycosylated Humans Insulin Magnetic Resonance Imaging Male |
| spellingShingle |
Alzheimer's disease Dementia risk factors Glucose Glycated hemoglobin Insulin Non-insulin-dependent Type II diabetes mellitus Vascular dementia glucose glycosylated hemoglobin insulin aged Alzheimer disease analysis of variance article comparative study controlled study correlation analysis female glucose blood level hemoglobin blood level human insulin blood level major clinical study male multiinfarct dementia non insulin dependent diabetes mellitus priority journal statistics Aged Alzheimer Disease Blood Glucose Brain Dementia, Vascular Diabetes Mellitus, Type 2 Female Hemoglobin A, Glycosylated Humans Insulin Magnetic Resonance Imaging Male Marschoff, Enrique R. Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition |
| topic_facet |
Alzheimer's disease Dementia risk factors Glucose Glycated hemoglobin Insulin Non-insulin-dependent Type II diabetes mellitus Vascular dementia glucose glycosylated hemoglobin insulin aged Alzheimer disease analysis of variance article comparative study controlled study correlation analysis female glucose blood level hemoglobin blood level human insulin blood level major clinical study male multiinfarct dementia non insulin dependent diabetes mellitus priority journal statistics Aged Alzheimer Disease Blood Glucose Brain Dementia, Vascular Diabetes Mellitus, Type 2 Female Hemoglobin A, Glycosylated Humans Insulin Magnetic Resonance Imaging Male |
| description |
Increased concentrations of insulin, glucose and glycohemoglobin are associated with Type II diabetes mellitus (DM) and recognized as characteristic markers of the disease; in Alzheimer's (AD), Vascular dementia (VaD), and both dementia's with superimposed diabetes (AD + DM, VaD + DM) the knowledge is scarce. The sample (n = 122; males = 60; mean age = 73 ± 7) comprised DM, AD, VaD, AD + DM, and VaD + DM patients, and healthy controls (C). The ANOVA's yielded significant differences between groups: Insulin p = 3.7 × 10 -3; Glucose p < 10-12; Glycohemoglobin p = 9.2×10-4. Comparisons between groups (DM vs. C, AD + DM vs. AD, VaD + DM vs. VaD, and demented DM vs. non-demented DM) resulted significant for all variables (Bonferroni's statistic, α = 0.05). Diabetic and diabetic demented patients presented significant increases largely different from controls (0.01 < p < 0.001), unlike the non-significant changes in their non-diabetic counterparts; linear relationships were found across all groups. The correlation's insulin/glucose and insulin/glycohemoglobin change to positive within demented groups, indicating a different performance of insulin in demented and non-demented subjects. © 2007 Springer-Verlag. |
| author |
Marschoff, Enrique R. |
| author_facet |
Marschoff, Enrique R. |
| author_sort |
Marschoff, Enrique R. |
| title |
Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition |
| title_short |
Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition |
| title_full |
Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition |
| title_fullStr |
Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition |
| title_full_unstemmed |
Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition |
| title_sort |
insulin, glucose and glycated hemoglobin in alzheimer's and vascular dementia with and without superimposed type ii diabetes mellitus condition |
| publishDate |
2008 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v115_n1_p77_Dominguez http://hdl.handle.net/20.500.12110/paper_03009564_v115_n1_p77_Dominguez |
| work_keys_str_mv |
AT marschoffenriquer insulinglucoseandglycatedhemoglobininalzheimersandvasculardementiawithandwithoutsuperimposedtypeiidiabetesmellituscondition |
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