Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients
Antioxidant profiles in Parkinson's disease (PD; n = 15), dementias of Alzheimer's type (DAT; 18) and Vascular (VD; 15), and control subjects (C; 14) were studied. Cu-Zn superoxide dismutase (SOD), catalase (CAT), glutathione system (GLU) and thiobarbituric acid reactive substances (TBARS)...
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paper:paper_03009564_v108_n10_p1135_Serra2023-06-08T15:27:38Z Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients Marschoff, Enrique R. Antioxidant system Cu-Zn superoxide dismutase Dementia of the Alzheimer's type Oxygen free radicals Parkinson's disease Peripheral markers Vascular dementia antioxidant catalase copper zinc superoxide dismutase glutathione thiobarbituric acid reactive substance Alzheimer disease antioxidant activity article biochemistry blood analysis controlled study disease marker enzyme assay erythrocyte level human major clinical study multiinfarct dementia oxidative stress Parkinson disease priority journal Aged Aged, 80 and over Alzheimer Disease Analysis of Variance Antioxidants Dementia, Vascular Discriminant Analysis Female Humans Male Middle Aged Oxidative Stress Parkinson Disease Statistics, Nonparametric Antioxidant profiles in Parkinson's disease (PD; n = 15), dementias of Alzheimer's type (DAT; 18) and Vascular (VD; 15), and control subjects (C; 14) were studied. Cu-Zn superoxide dismutase (SOD), catalase (CAT), glutathione system (GLU) and thiobarbituric acid reactive substances (TBARS) were measured in erythrocytes; antioxidant capacity (TRAP) in plasma. Biochemical variables were analyzed simultaneously using multivariate and non-parametric methods. Clinical diagnostic resulted associated with the main source of variability in antioxidant variables (Kruskal-Wallis: H = 32.58, p = 0.000001). Comparison of PD and C resulted highly significant (z = 4.47, p = 0.000047), demonstrating an association between oxidative stress and PD. SOD and TBARS were significantly higher in pathological groups against C (p = 0.0000001, p = 0.051); TRAP resulted lower (p = 0.00015). Discriminant functions constructed using biochemical variables separated pathological groups (93% success) from C, and DAT (88.9%) from VD (73.3%); but not PD from DAT or VD. Antioxidant profiles of PD patients showed characteristics overlapping with DAT (60%) and with VD (40%), suggesting biochemical similarities between them. Fil:Marschoff, E.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2001 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v108_n10_p1135_Serra http://hdl.handle.net/20.500.12110/paper_03009564_v108_n10_p1135_Serra |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Antioxidant system Cu-Zn superoxide dismutase Dementia of the Alzheimer's type Oxygen free radicals Parkinson's disease Peripheral markers Vascular dementia antioxidant catalase copper zinc superoxide dismutase glutathione thiobarbituric acid reactive substance Alzheimer disease antioxidant activity article biochemistry blood analysis controlled study disease marker enzyme assay erythrocyte level human major clinical study multiinfarct dementia oxidative stress Parkinson disease priority journal Aged Aged, 80 and over Alzheimer Disease Analysis of Variance Antioxidants Dementia, Vascular Discriminant Analysis Female Humans Male Middle Aged Oxidative Stress Parkinson Disease Statistics, Nonparametric |
spellingShingle |
Antioxidant system Cu-Zn superoxide dismutase Dementia of the Alzheimer's type Oxygen free radicals Parkinson's disease Peripheral markers Vascular dementia antioxidant catalase copper zinc superoxide dismutase glutathione thiobarbituric acid reactive substance Alzheimer disease antioxidant activity article biochemistry blood analysis controlled study disease marker enzyme assay erythrocyte level human major clinical study multiinfarct dementia oxidative stress Parkinson disease priority journal Aged Aged, 80 and over Alzheimer Disease Analysis of Variance Antioxidants Dementia, Vascular Discriminant Analysis Female Humans Male Middle Aged Oxidative Stress Parkinson Disease Statistics, Nonparametric Marschoff, Enrique R. Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients |
topic_facet |
Antioxidant system Cu-Zn superoxide dismutase Dementia of the Alzheimer's type Oxygen free radicals Parkinson's disease Peripheral markers Vascular dementia antioxidant catalase copper zinc superoxide dismutase glutathione thiobarbituric acid reactive substance Alzheimer disease antioxidant activity article biochemistry blood analysis controlled study disease marker enzyme assay erythrocyte level human major clinical study multiinfarct dementia oxidative stress Parkinson disease priority journal Aged Aged, 80 and over Alzheimer Disease Analysis of Variance Antioxidants Dementia, Vascular Discriminant Analysis Female Humans Male Middle Aged Oxidative Stress Parkinson Disease Statistics, Nonparametric |
description |
Antioxidant profiles in Parkinson's disease (PD; n = 15), dementias of Alzheimer's type (DAT; 18) and Vascular (VD; 15), and control subjects (C; 14) were studied. Cu-Zn superoxide dismutase (SOD), catalase (CAT), glutathione system (GLU) and thiobarbituric acid reactive substances (TBARS) were measured in erythrocytes; antioxidant capacity (TRAP) in plasma. Biochemical variables were analyzed simultaneously using multivariate and non-parametric methods. Clinical diagnostic resulted associated with the main source of variability in antioxidant variables (Kruskal-Wallis: H = 32.58, p = 0.000001). Comparison of PD and C resulted highly significant (z = 4.47, p = 0.000047), demonstrating an association between oxidative stress and PD. SOD and TBARS were significantly higher in pathological groups against C (p = 0.0000001, p = 0.051); TRAP resulted lower (p = 0.00015). Discriminant functions constructed using biochemical variables separated pathological groups (93% success) from C, and DAT (88.9%) from VD (73.3%); but not PD from DAT or VD. Antioxidant profiles of PD patients showed characteristics overlapping with DAT (60%) and with VD (40%), suggesting biochemical similarities between them. |
author |
Marschoff, Enrique R. |
author_facet |
Marschoff, Enrique R. |
author_sort |
Marschoff, Enrique R. |
title |
Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients |
title_short |
Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients |
title_full |
Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients |
title_fullStr |
Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients |
title_full_unstemmed |
Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients |
title_sort |
parkinson's disease is associated with oxidative stress: comparison of peripheral antioxidant profiles in living parkinson's, alzheimer's and vascular dementia patients |
publishDate |
2001 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v108_n10_p1135_Serra http://hdl.handle.net/20.500.12110/paper_03009564_v108_n10_p1135_Serra |
work_keys_str_mv |
AT marschoffenriquer parkinsonsdiseaseisassociatedwithoxidativestresscomparisonofperipheralantioxidantprofilesinlivingparkinsonsalzheimersandvasculardementiapatients |
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1768542036648001536 |