Repeat proteins challenge the concept of structural domains

Structural domains are believed to be modules within proteins that can fold and function independently. Some proteins show tandem repetitions of apparent modular structure that do not fold independently, but rather co-operate in stabilizing structural forms that comprise several repeat-units. For ma...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autor principal: Ferreiro, Diego U.
Publicado: 2015
Materias:
Ankyrin-repeat
Local frustration
Repeat-protein
protein
repeat protein
unclassified drug
Article
molecular evolution
physiological process
priority journal
protein analysis
protein domain
protein folding
amino acid sequence
animal
chemical structure
energy transfer
human
protein conformation
protein secondary structure
protein stability
protein tertiary structure
tandem repeat
Animals
Energy Transfer
Evolution, Molecular
Humans
Models, Molecular
Protein Conformation
Protein Folding
Protein Interaction Domains and Motifs
Protein Stability
Protein Structure, Secondary
Protein Structure, Tertiary
Repetitive Sequences, Amino Acid
Tandem Repeat Sequences
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03005127_v43_n_p844_Espada
http://hdl.handle.net/20.500.12110/paper_03005127_v43_n_p844_Espada
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_03005127_v43_n_p844_Espada
record_format dspace
spelling paper:paper_03005127_v43_n_p844_Espada2023-06-08T15:27:19Z Repeat proteins challenge the concept of structural domains Ferreiro, Diego U. Ankyrin-repeat Local frustration Repeat-protein protein repeat protein unclassified drug Article molecular evolution physiological process priority journal protein analysis protein domain protein folding amino acid sequence animal chemical structure energy transfer human protein conformation protein domain protein secondary structure protein stability protein tertiary structure tandem repeat Animals Energy Transfer Evolution, Molecular Humans Models, Molecular Protein Conformation Protein Folding Protein Interaction Domains and Motifs Protein Stability Protein Structure, Secondary Protein Structure, Tertiary Repetitive Sequences, Amino Acid Tandem Repeat Sequences Structural domains are believed to be modules within proteins that can fold and function independently. Some proteins show tandem repetitions of apparent modular structure that do not fold independently, but rather co-operate in stabilizing structural forms that comprise several repeat-units. For many natural repeat-proteins, it has been shown that weak energetic links between repeats lead to the breakdown of co-operativity and the appearance of folding sub-domains within an apparently regular repeat array. The quasi-1D architecture of repeat-proteins is crucial in detailing how the local energetic balances can modulate the folding dynamics of these proteins, which can be related to the physiological behaviour of these ubiquitous biological systems. © 2015 Authors; published by Portland Press Limited. Fil:Ferreiro, D.U. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03005127_v43_n_p844_Espada http://hdl.handle.net/20.500.12110/paper_03005127_v43_n_p844_Espada
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Ankyrin-repeat
Local frustration
Repeat-protein
protein
repeat protein
unclassified drug
Article
molecular evolution
physiological process
priority journal
protein analysis
protein domain
protein folding
amino acid sequence
animal
chemical structure
energy transfer
human
protein conformation
protein domain
protein secondary structure
protein stability
protein tertiary structure
tandem repeat
Animals
Energy Transfer
Evolution, Molecular
Humans
Models, Molecular
Protein Conformation
Protein Folding
Protein Interaction Domains and Motifs
Protein Stability
Protein Structure, Secondary
Protein Structure, Tertiary
Repetitive Sequences, Amino Acid
Tandem Repeat Sequences
spellingShingle Ankyrin-repeat
Local frustration
Repeat-protein
protein
repeat protein
unclassified drug
Article
molecular evolution
physiological process
priority journal
protein analysis
protein domain
protein folding
amino acid sequence
animal
chemical structure
energy transfer
human
protein conformation
protein domain
protein secondary structure
protein stability
protein tertiary structure
tandem repeat
Animals
Energy Transfer
Evolution, Molecular
Humans
Models, Molecular
Protein Conformation
Protein Folding
Protein Interaction Domains and Motifs
Protein Stability
Protein Structure, Secondary
Protein Structure, Tertiary
Repetitive Sequences, Amino Acid
Tandem Repeat Sequences
Ferreiro, Diego U.
Repeat proteins challenge the concept of structural domains
topic_facet Ankyrin-repeat
Local frustration
Repeat-protein
protein
repeat protein
unclassified drug
Article
molecular evolution
physiological process
priority journal
protein analysis
protein domain
protein folding
amino acid sequence
animal
chemical structure
energy transfer
human
protein conformation
protein domain
protein secondary structure
protein stability
protein tertiary structure
tandem repeat
Animals
Energy Transfer
Evolution, Molecular
Humans
Models, Molecular
Protein Conformation
Protein Folding
Protein Interaction Domains and Motifs
Protein Stability
Protein Structure, Secondary
Protein Structure, Tertiary
Repetitive Sequences, Amino Acid
Tandem Repeat Sequences
description Structural domains are believed to be modules within proteins that can fold and function independently. Some proteins show tandem repetitions of apparent modular structure that do not fold independently, but rather co-operate in stabilizing structural forms that comprise several repeat-units. For many natural repeat-proteins, it has been shown that weak energetic links between repeats lead to the breakdown of co-operativity and the appearance of folding sub-domains within an apparently regular repeat array. The quasi-1D architecture of repeat-proteins is crucial in detailing how the local energetic balances can modulate the folding dynamics of these proteins, which can be related to the physiological behaviour of these ubiquitous biological systems. © 2015 Authors; published by Portland Press Limited.
author Ferreiro, Diego U.
author_facet Ferreiro, Diego U.
author_sort Ferreiro, Diego U.
title Repeat proteins challenge the concept of structural domains
title_short Repeat proteins challenge the concept of structural domains
title_full Repeat proteins challenge the concept of structural domains
title_fullStr Repeat proteins challenge the concept of structural domains
title_full_unstemmed Repeat proteins challenge the concept of structural domains
title_sort repeat proteins challenge the concept of structural domains
publishDate 2015
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03005127_v43_n_p844_Espada
http://hdl.handle.net/20.500.12110/paper_03005127_v43_n_p844_Espada
work_keys_str_mv AT ferreirodiegou repeatproteinschallengetheconceptofstructuraldomains
_version_ 1768544084832550912

Ejemplares similares