Effects of the porphyrinogenic compounds hexachlorobenzene and 3,5-diethoxycarbonyl-1,4-dihydrocollidine on polyamine metabolism
The naturally occurring polyamines - putrescine, spermidine and spermine - are organic cations present in all living cells and essential for cell growth and differentiation. The aim of the present study was to extend the investigations on the effects of porphyrinogenic compounds on polyamine metabol...
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2002
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0300483X_v176_n3_p209_Cochon http://hdl.handle.net/20.500.12110/paper_0300483X_v176_n3_p209_Cochon |
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paper:paper_0300483X_v176_n3_p209_Cochon2023-06-08T15:27:15Z Effects of the porphyrinogenic compounds hexachlorobenzene and 3,5-diethoxycarbonyl-1,4-dihydrocollidine on polyamine metabolism 3,5-Diethoxycarbonyl-1,4-dihydrocollidine Hexachlorobenzene Ornithine decarboxylase Polyamine Porphyrin Putrescine Rat Spermidine Spermine 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester hexachlorobenzene ornithine decarboxylase putrescine spermidine spermine adrenal gland animal experiment animal model animal tissue antibody specificity article biosynthesis blood level controlled study cytoskeleton female liver liver cell male nonhuman polyamine metabolism porphyria priority journal rat 5-Aminolevulinate Synthetase Animals Biogenic Polyamines Dicarbethoxydihydrocollidine Female Ferrochelatase Hexachlorobenzene Liver Male Ornithine Decarboxylase Porphyrins Proteins Rats Rats, Sprague-Dawley Rats, Wistar Sex Characteristics Uroporphyrinogen Decarboxylase Rattus norvegicus The naturally occurring polyamines - putrescine, spermidine and spermine - are organic cations present in all living cells and essential for cell growth and differentiation. The aim of the present study was to extend the investigations on the effects of porphyrinogenic compounds on polyamine metabolism. This was achieved by studying putrescine, spermidine and spermine levels in a model of acute porphyria, i.e. 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced porphyria, and in a model of non-acute porphyria, i.e. hexachlorobenzene (HCB)-induced porphyria. HCB administration to female Wistar rats for 7, 14, 21, 28 and 56 days did not alter polyamine levels in liver, even though rats presented clear signs of HCB-induced porphyria. In contrast to HCB, DDC treatment resulted in a remarkable increase in putrescine levels in the liver of female and male Sprague-Dawley rats. This increase was due, at least in part, to ornithine decarboxylase (ODC) activation. DDC induction of putrescine levels did not show organ specificity, since it could also be seen in adrenal gland. Interestingly, the deregulation of polyamine biosynthesis occurred concomitantly with the deregulation of the heme biosynthetic pathway. In addition to porphyria, it is known that DDC intoxication affects several proteins of the hepatocyte cytoskeleton. It is suggested that DDC-induced increase in ODC activity and putrescine levels may be an early event contributing to alter the cytoskeleton. © 2002 Elsevier Science Ireland Ltd. All rights reserved. 2002 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0300483X_v176_n3_p209_Cochon http://hdl.handle.net/20.500.12110/paper_0300483X_v176_n3_p209_Cochon |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
3,5-Diethoxycarbonyl-1,4-dihydrocollidine Hexachlorobenzene Ornithine decarboxylase Polyamine Porphyrin Putrescine Rat Spermidine Spermine 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester hexachlorobenzene ornithine decarboxylase putrescine spermidine spermine adrenal gland animal experiment animal model animal tissue antibody specificity article biosynthesis blood level controlled study cytoskeleton female liver liver cell male nonhuman polyamine metabolism porphyria priority journal rat 5-Aminolevulinate Synthetase Animals Biogenic Polyamines Dicarbethoxydihydrocollidine Female Ferrochelatase Hexachlorobenzene Liver Male Ornithine Decarboxylase Porphyrins Proteins Rats Rats, Sprague-Dawley Rats, Wistar Sex Characteristics Uroporphyrinogen Decarboxylase Rattus norvegicus |
| spellingShingle |
3,5-Diethoxycarbonyl-1,4-dihydrocollidine Hexachlorobenzene Ornithine decarboxylase Polyamine Porphyrin Putrescine Rat Spermidine Spermine 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester hexachlorobenzene ornithine decarboxylase putrescine spermidine spermine adrenal gland animal experiment animal model animal tissue antibody specificity article biosynthesis blood level controlled study cytoskeleton female liver liver cell male nonhuman polyamine metabolism porphyria priority journal rat 5-Aminolevulinate Synthetase Animals Biogenic Polyamines Dicarbethoxydihydrocollidine Female Ferrochelatase Hexachlorobenzene Liver Male Ornithine Decarboxylase Porphyrins Proteins Rats Rats, Sprague-Dawley Rats, Wistar Sex Characteristics Uroporphyrinogen Decarboxylase Rattus norvegicus Effects of the porphyrinogenic compounds hexachlorobenzene and 3,5-diethoxycarbonyl-1,4-dihydrocollidine on polyamine metabolism |
| topic_facet |
3,5-Diethoxycarbonyl-1,4-dihydrocollidine Hexachlorobenzene Ornithine decarboxylase Polyamine Porphyrin Putrescine Rat Spermidine Spermine 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester hexachlorobenzene ornithine decarboxylase putrescine spermidine spermine adrenal gland animal experiment animal model animal tissue antibody specificity article biosynthesis blood level controlled study cytoskeleton female liver liver cell male nonhuman polyamine metabolism porphyria priority journal rat 5-Aminolevulinate Synthetase Animals Biogenic Polyamines Dicarbethoxydihydrocollidine Female Ferrochelatase Hexachlorobenzene Liver Male Ornithine Decarboxylase Porphyrins Proteins Rats Rats, Sprague-Dawley Rats, Wistar Sex Characteristics Uroporphyrinogen Decarboxylase Rattus norvegicus |
| description |
The naturally occurring polyamines - putrescine, spermidine and spermine - are organic cations present in all living cells and essential for cell growth and differentiation. The aim of the present study was to extend the investigations on the effects of porphyrinogenic compounds on polyamine metabolism. This was achieved by studying putrescine, spermidine and spermine levels in a model of acute porphyria, i.e. 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced porphyria, and in a model of non-acute porphyria, i.e. hexachlorobenzene (HCB)-induced porphyria. HCB administration to female Wistar rats for 7, 14, 21, 28 and 56 days did not alter polyamine levels in liver, even though rats presented clear signs of HCB-induced porphyria. In contrast to HCB, DDC treatment resulted in a remarkable increase in putrescine levels in the liver of female and male Sprague-Dawley rats. This increase was due, at least in part, to ornithine decarboxylase (ODC) activation. DDC induction of putrescine levels did not show organ specificity, since it could also be seen in adrenal gland. Interestingly, the deregulation of polyamine biosynthesis occurred concomitantly with the deregulation of the heme biosynthetic pathway. In addition to porphyria, it is known that DDC intoxication affects several proteins of the hepatocyte cytoskeleton. It is suggested that DDC-induced increase in ODC activity and putrescine levels may be an early event contributing to alter the cytoskeleton. © 2002 Elsevier Science Ireland Ltd. All rights reserved. |
| title |
Effects of the porphyrinogenic compounds hexachlorobenzene and 3,5-diethoxycarbonyl-1,4-dihydrocollidine on polyamine metabolism |
| title_short |
Effects of the porphyrinogenic compounds hexachlorobenzene and 3,5-diethoxycarbonyl-1,4-dihydrocollidine on polyamine metabolism |
| title_full |
Effects of the porphyrinogenic compounds hexachlorobenzene and 3,5-diethoxycarbonyl-1,4-dihydrocollidine on polyamine metabolism |
| title_fullStr |
Effects of the porphyrinogenic compounds hexachlorobenzene and 3,5-diethoxycarbonyl-1,4-dihydrocollidine on polyamine metabolism |
| title_full_unstemmed |
Effects of the porphyrinogenic compounds hexachlorobenzene and 3,5-diethoxycarbonyl-1,4-dihydrocollidine on polyamine metabolism |
| title_sort |
effects of the porphyrinogenic compounds hexachlorobenzene and 3,5-diethoxycarbonyl-1,4-dihydrocollidine on polyamine metabolism |
| publishDate |
2002 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0300483X_v176_n3_p209_Cochon http://hdl.handle.net/20.500.12110/paper_0300483X_v176_n3_p209_Cochon |
| _version_ |
1768545050533298176 |