Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat
1. After reaching its final destination the GnRH neuronal network develops under the influence of both excitatory and inhibitory inputs. 2. In the first 2 weeks of life, the immaturity of the GnRH neuronal system is reflected in sporadic unsynchronized bursts of the decapeptide, which determine the...
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1995
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02724340_v15_n1_p165_BecuVillalobos http://hdl.handle.net/20.500.12110/paper_02724340_v15_n1_p165_BecuVillalobos |
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paper:paper_02724340_v15_n1_p165_BecuVillalobos2023-06-08T15:25:03Z Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat gonadotropin-releasing hormone growth factors neurotransmitters ontogeny rat gonadorelin animal experiment dopaminergic system female gonadorelin release hormonal regulation nerve cell network neurotransmission nonhuman priority journal puberty rat review Aging Animal Catecholamines Dopamine Endorphins Excitatory Amino Acids Female Follicle Stimulating Hormone Gonadorelin Homeostasis Hypothalamo-Hypophyseal System Luteinizing Hormone Neurons Neuropeptides Norepinephrine Rats Serotonin Support, Non-U.S. Gov't Synapses Animalia 1. After reaching its final destination the GnRH neuronal network develops under the influence of both excitatory and inhibitory inputs. 2. In the first 2 weeks of life, the immaturity of the GnRH neuronal system is reflected in sporadic unsynchronized bursts of the decapeptide, which determine the pattern of serum gonadotropin levels observed in female rats: high FSH levels and transient bursts of LH. The main inhibitory neuronal systems that operate in this period are the opioid and dopaminergic systems. A decrease in their inhibitory effectiveness may not be sufficient correctly to activate and synchronize the GnRH neuronal system. 3. There is a concomitant increase in excitatory inputs, mainly noradrenaline, excitatory amino acids, and NPY, which increase the synthesis and release of GnRH at the beginning of the juvenile period and participate in the coupling of GnRH neural activity to the ongoing rhythmic activity of a hypothalamic circadian oscillator. 4. The morphological changes of GnRH neurons which take place during the third and fourth weeks of life, and which are probably related to increasing estradiol levels, reflects the increasing complexity of the GnRH neuronal network, which establishes synaptic contacts to enable the expression of pulsatility and of the positive feedback of estradiol, both necessary components for the occurrence of puberty. © 1995 Plenum Publishing Corporation. 1995 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02724340_v15_n1_p165_BecuVillalobos http://hdl.handle.net/20.500.12110/paper_02724340_v15_n1_p165_BecuVillalobos |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
gonadotropin-releasing hormone growth factors neurotransmitters ontogeny rat gonadorelin animal experiment dopaminergic system female gonadorelin release hormonal regulation nerve cell network neurotransmission nonhuman priority journal puberty rat review Aging Animal Catecholamines Dopamine Endorphins Excitatory Amino Acids Female Follicle Stimulating Hormone Gonadorelin Homeostasis Hypothalamo-Hypophyseal System Luteinizing Hormone Neurons Neuropeptides Norepinephrine Rats Serotonin Support, Non-U.S. Gov't Synapses Animalia |
| spellingShingle |
gonadotropin-releasing hormone growth factors neurotransmitters ontogeny rat gonadorelin animal experiment dopaminergic system female gonadorelin release hormonal regulation nerve cell network neurotransmission nonhuman priority journal puberty rat review Aging Animal Catecholamines Dopamine Endorphins Excitatory Amino Acids Female Follicle Stimulating Hormone Gonadorelin Homeostasis Hypothalamo-Hypophyseal System Luteinizing Hormone Neurons Neuropeptides Norepinephrine Rats Serotonin Support, Non-U.S. Gov't Synapses Animalia Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat |
| topic_facet |
gonadotropin-releasing hormone growth factors neurotransmitters ontogeny rat gonadorelin animal experiment dopaminergic system female gonadorelin release hormonal regulation nerve cell network neurotransmission nonhuman priority journal puberty rat review Aging Animal Catecholamines Dopamine Endorphins Excitatory Amino Acids Female Follicle Stimulating Hormone Gonadorelin Homeostasis Hypothalamo-Hypophyseal System Luteinizing Hormone Neurons Neuropeptides Norepinephrine Rats Serotonin Support, Non-U.S. Gov't Synapses Animalia |
| description |
1. After reaching its final destination the GnRH neuronal network develops under the influence of both excitatory and inhibitory inputs. 2. In the first 2 weeks of life, the immaturity of the GnRH neuronal system is reflected in sporadic unsynchronized bursts of the decapeptide, which determine the pattern of serum gonadotropin levels observed in female rats: high FSH levels and transient bursts of LH. The main inhibitory neuronal systems that operate in this period are the opioid and dopaminergic systems. A decrease in their inhibitory effectiveness may not be sufficient correctly to activate and synchronize the GnRH neuronal system. 3. There is a concomitant increase in excitatory inputs, mainly noradrenaline, excitatory amino acids, and NPY, which increase the synthesis and release of GnRH at the beginning of the juvenile period and participate in the coupling of GnRH neural activity to the ongoing rhythmic activity of a hypothalamic circadian oscillator. 4. The morphological changes of GnRH neurons which take place during the third and fourth weeks of life, and which are probably related to increasing estradiol levels, reflects the increasing complexity of the GnRH neuronal network, which establishes synaptic contacts to enable the expression of pulsatility and of the positive feedback of estradiol, both necessary components for the occurrence of puberty. © 1995 Plenum Publishing Corporation. |
| title |
Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat |
| title_short |
Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat |
| title_full |
Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat |
| title_fullStr |
Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat |
| title_full_unstemmed |
Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat |
| title_sort |
development of gonadotropin-releasing hormone (gnrh) neuron regulation in the female rat |
| publishDate |
1995 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02724340_v15_n1_p165_BecuVillalobos http://hdl.handle.net/20.500.12110/paper_02724340_v15_n1_p165_BecuVillalobos |
| _version_ |
1768542125353336832 |