Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth
Cross talk between the steroid hormone receptors for estrogen and progesterone (PR) and the ErbB family of receptor tyrosine kinases appears to be a hallmark of breast cancer growth, but its underlying mechanism remains poorly explored. Here we have highlighted signal transducer and activator of tra...
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2009
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02707306_v29_n5_p1249_Proietti http://hdl.handle.net/20.500.12110/paper_02707306_v29_n5_p1249_Proietti |
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paper:paper_02707306_v29_n5_p1249_Proietti2023-06-08T15:24:56Z Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth epidermal growth factor receptor 2 estrogen receptor neu differentiation factor progesterone receptor STAT3 protein epidermal growth factor receptor 2 neu differentiation factor progesterone receptor STAT3 protein animal cell animal cell culture animal experiment animal model article Bagg albino mouse breast cancer cancer growth enzyme activity female immunoprecipitation mouse nonhuman priority journal signal transduction Western blotting animal cell proliferation experimental neoplasm metabolism pathology Animals Cell Proliferation Female Mammary Neoplasms, Animal Mice Mice, Inbred BALB C Neuregulin-1 Receptor, erbB-2 Receptors, Progesterone Signal Transduction STAT3 Transcription Factor Cross talk between the steroid hormone receptors for estrogen and progesterone (PR) and the ErbB family of receptor tyrosine kinases appears to be a hallmark of breast cancer growth, but its underlying mechanism remains poorly explored. Here we have highlighted signal transducer and activator of transcription 3 (Stat3) as a key protein activated by heregulin (HRG), a ligand of the ErbB receptors, through co-opted, ligand-independent PR function as a signaling molecule. Stat3 activation was an absolute requirement in HRG-induced mammary tumor growth, and targeting Stat3 effectively inhibited growth of breast cancer cells with activated HRG/ErbB-2 and PR. Our findings unravel a novel potential therapeutic intervention in PR- and ErbB-2-positive breast tumors, involving the specific blockage of PR signaling activity. Copyright © 2009, American Society for Microbiology. All Rights Reserved. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02707306_v29_n5_p1249_Proietti http://hdl.handle.net/20.500.12110/paper_02707306_v29_n5_p1249_Proietti |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
epidermal growth factor receptor 2 estrogen receptor neu differentiation factor progesterone receptor STAT3 protein epidermal growth factor receptor 2 neu differentiation factor progesterone receptor STAT3 protein animal cell animal cell culture animal experiment animal model article Bagg albino mouse breast cancer cancer growth enzyme activity female immunoprecipitation mouse nonhuman priority journal signal transduction Western blotting animal cell proliferation experimental neoplasm metabolism pathology Animals Cell Proliferation Female Mammary Neoplasms, Animal Mice Mice, Inbred BALB C Neuregulin-1 Receptor, erbB-2 Receptors, Progesterone Signal Transduction STAT3 Transcription Factor |
| spellingShingle |
epidermal growth factor receptor 2 estrogen receptor neu differentiation factor progesterone receptor STAT3 protein epidermal growth factor receptor 2 neu differentiation factor progesterone receptor STAT3 protein animal cell animal cell culture animal experiment animal model article Bagg albino mouse breast cancer cancer growth enzyme activity female immunoprecipitation mouse nonhuman priority journal signal transduction Western blotting animal cell proliferation experimental neoplasm metabolism pathology Animals Cell Proliferation Female Mammary Neoplasms, Animal Mice Mice, Inbred BALB C Neuregulin-1 Receptor, erbB-2 Receptors, Progesterone Signal Transduction STAT3 Transcription Factor Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth |
| topic_facet |
epidermal growth factor receptor 2 estrogen receptor neu differentiation factor progesterone receptor STAT3 protein epidermal growth factor receptor 2 neu differentiation factor progesterone receptor STAT3 protein animal cell animal cell culture animal experiment animal model article Bagg albino mouse breast cancer cancer growth enzyme activity female immunoprecipitation mouse nonhuman priority journal signal transduction Western blotting animal cell proliferation experimental neoplasm metabolism pathology Animals Cell Proliferation Female Mammary Neoplasms, Animal Mice Mice, Inbred BALB C Neuregulin-1 Receptor, erbB-2 Receptors, Progesterone Signal Transduction STAT3 Transcription Factor |
| description |
Cross talk between the steroid hormone receptors for estrogen and progesterone (PR) and the ErbB family of receptor tyrosine kinases appears to be a hallmark of breast cancer growth, but its underlying mechanism remains poorly explored. Here we have highlighted signal transducer and activator of transcription 3 (Stat3) as a key protein activated by heregulin (HRG), a ligand of the ErbB receptors, through co-opted, ligand-independent PR function as a signaling molecule. Stat3 activation was an absolute requirement in HRG-induced mammary tumor growth, and targeting Stat3 effectively inhibited growth of breast cancer cells with activated HRG/ErbB-2 and PR. Our findings unravel a novel potential therapeutic intervention in PR- and ErbB-2-positive breast tumors, involving the specific blockage of PR signaling activity. Copyright © 2009, American Society for Microbiology. All Rights Reserved. |
| title |
Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth |
| title_short |
Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth |
| title_full |
Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth |
| title_fullStr |
Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth |
| title_full_unstemmed |
Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth |
| title_sort |
activation of stat3 by heregulin/erbb-2 through the co-option of progesterone receptor signaling drives breast cancer growth |
| publishDate |
2009 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02707306_v29_n5_p1249_Proietti http://hdl.handle.net/20.500.12110/paper_02707306_v29_n5_p1249_Proietti |
| _version_ |
1768543228182659072 |