Feedback signal from motoneurons influences a rhythmic pattern generator
Motoneurons are not mere output units of neuronal circuits that control motor behavior but participate in pattern generation. Research on the circuit that controls the crawling motor behavior in leeches indicated that motoneurons participate as modulators of this rhythmic motor pattern. Crawling res...
Guardado en:
| Publicado: |
2017
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v37_n38_p9149_Rotstein http://hdl.handle.net/20.500.12110/paper_02706474_v37_n38_p9149_Rotstein |
| Aporte de: |
| id |
paper:paper_02706474_v37_n38_p9149_Rotstein |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_02706474_v37_n38_p9149_Rotstein2023-06-08T15:24:53Z Feedback signal from motoneurons influences a rhythmic pattern generator Duty cycle Dye coupling Lecar model Leech crawling Left-right symmetry Morris Phase relationship Article computer model connectome electrophysiological procedures ganglion hyperpolarization motoneuron muscle cell nerve cell nerve conduction neurite neurofeedback nonhuman pattern generator priority journal rhythm adaptation animal central pattern generator leech locomotion motoneuron nerve cell network periodicity physiological feedback physiology Adaptation, Physiological Animals Central Pattern Generators Feedback, Physiological Leeches Locomotion Motor Neurons Nerve Net Periodicity Motoneurons are not mere output units of neuronal circuits that control motor behavior but participate in pattern generation. Research on the circuit that controls the crawling motor behavior in leeches indicated that motoneurons participate as modulators of this rhythmic motor pattern. Crawling results from successive bouts of elongation and contraction of the whole leech body. In the isolated segmental ganglia, dopamine can induce a rhythmic antiphasic activity of the motoneurons that control contraction (DE-3 motoneurons) and elongation (CV motoneurons). The study was performed in isolated ganglia where manipulation of the activity of specific motoneurons was performed in the course of fictive crawling (crawling). In this study, the membrane potential of CV was manipulated while crawling was monitored through the rhythmic activity of DE-3. Matching behavioral observations that show that elongation dominates the rhythmic pattern, the electrophysiological activity of CV motoneurons dominates the cycle. Brief excitation of CV motoneurons during crawling episodes resets the rhythmic activity of DE-3, indicating that CV feeds back to the rhythmic pattern generator. CV hyperpolarization accelerated the rhythm to an extent that depended on the magnitude of the cycle period, suggesting that CV exerted a positive feedback on the unit(s) of the pattern generator that controls the elongation phase. A simple computational model was implemented to test the consequences of such feedback. The simulations indicate that the duty cycle of CV depended on the strength of the positive feedback between CV and the pattern generator circuit. © 2017 the authors. 2017 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v37_n38_p9149_Rotstein http://hdl.handle.net/20.500.12110/paper_02706474_v37_n38_p9149_Rotstein |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Duty cycle Dye coupling Lecar model Leech crawling Left-right symmetry Morris Phase relationship Article computer model connectome electrophysiological procedures ganglion hyperpolarization motoneuron muscle cell nerve cell nerve conduction neurite neurofeedback nonhuman pattern generator priority journal rhythm adaptation animal central pattern generator leech locomotion motoneuron nerve cell network periodicity physiological feedback physiology Adaptation, Physiological Animals Central Pattern Generators Feedback, Physiological Leeches Locomotion Motor Neurons Nerve Net Periodicity |
| spellingShingle |
Duty cycle Dye coupling Lecar model Leech crawling Left-right symmetry Morris Phase relationship Article computer model connectome electrophysiological procedures ganglion hyperpolarization motoneuron muscle cell nerve cell nerve conduction neurite neurofeedback nonhuman pattern generator priority journal rhythm adaptation animal central pattern generator leech locomotion motoneuron nerve cell network periodicity physiological feedback physiology Adaptation, Physiological Animals Central Pattern Generators Feedback, Physiological Leeches Locomotion Motor Neurons Nerve Net Periodicity Feedback signal from motoneurons influences a rhythmic pattern generator |
| topic_facet |
Duty cycle Dye coupling Lecar model Leech crawling Left-right symmetry Morris Phase relationship Article computer model connectome electrophysiological procedures ganglion hyperpolarization motoneuron muscle cell nerve cell nerve conduction neurite neurofeedback nonhuman pattern generator priority journal rhythm adaptation animal central pattern generator leech locomotion motoneuron nerve cell network periodicity physiological feedback physiology Adaptation, Physiological Animals Central Pattern Generators Feedback, Physiological Leeches Locomotion Motor Neurons Nerve Net Periodicity |
| description |
Motoneurons are not mere output units of neuronal circuits that control motor behavior but participate in pattern generation. Research on the circuit that controls the crawling motor behavior in leeches indicated that motoneurons participate as modulators of this rhythmic motor pattern. Crawling results from successive bouts of elongation and contraction of the whole leech body. In the isolated segmental ganglia, dopamine can induce a rhythmic antiphasic activity of the motoneurons that control contraction (DE-3 motoneurons) and elongation (CV motoneurons). The study was performed in isolated ganglia where manipulation of the activity of specific motoneurons was performed in the course of fictive crawling (crawling). In this study, the membrane potential of CV was manipulated while crawling was monitored through the rhythmic activity of DE-3. Matching behavioral observations that show that elongation dominates the rhythmic pattern, the electrophysiological activity of CV motoneurons dominates the cycle. Brief excitation of CV motoneurons during crawling episodes resets the rhythmic activity of DE-3, indicating that CV feeds back to the rhythmic pattern generator. CV hyperpolarization accelerated the rhythm to an extent that depended on the magnitude of the cycle period, suggesting that CV exerted a positive feedback on the unit(s) of the pattern generator that controls the elongation phase. A simple computational model was implemented to test the consequences of such feedback. The simulations indicate that the duty cycle of CV depended on the strength of the positive feedback between CV and the pattern generator circuit. © 2017 the authors. |
| title |
Feedback signal from motoneurons influences a rhythmic pattern generator |
| title_short |
Feedback signal from motoneurons influences a rhythmic pattern generator |
| title_full |
Feedback signal from motoneurons influences a rhythmic pattern generator |
| title_fullStr |
Feedback signal from motoneurons influences a rhythmic pattern generator |
| title_full_unstemmed |
Feedback signal from motoneurons influences a rhythmic pattern generator |
| title_sort |
feedback signal from motoneurons influences a rhythmic pattern generator |
| publishDate |
2017 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v37_n38_p9149_Rotstein http://hdl.handle.net/20.500.12110/paper_02706474_v37_n38_p9149_Rotstein |
| _version_ |
1768546065489854464 |