Central dopamine D2 receptors regulate growth-hormone- dependent body growth and pheromone signaling to conspecific males
Competition between adult males for limited resources such as food and receptive females is shaped by the male pattern of pituitary growth hormone (GH) secretion that determines body size and the production of urinary pheromones involved in male-to-male aggression. In the brain, dopamine (DA) provid...
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2013
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v33_n13_p5834_Noain http://hdl.handle.net/20.500.12110/paper_02706474_v33_n13_p5834_Noain |
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paper:paper_02706474_v33_n13_p5834_Noain2023-06-08T15:24:50Z Central dopamine D2 receptors regulate growth-hormone- dependent body growth and pheromone signaling to conspecific males dopamine dopamine 2 receptor growth hormone pheromone prolactin somatomedin C receptor animal experiment animal tissue article autoradiography behavior body growth body size body weight controlled study female fitness food intake immunofluorescence test in situ hybridization male motor unit potential mouse neurotransmission nonhuman priority journal radioimmunoassay real time polymerase chain reaction signal transduction social dominance Analysis of Variance Animals Benzamides Body Size Body Weight Case-Control Studies Catatonia Dopamine Antagonists Eating Female Growth Hormone Haloperidol Insulin-Like Growth Factor I Intermediate Filament Proteins Male Mice Mice, Inbred C57BL Mice, Transgenic Nerve Tissue Proteins Oligodeoxyribonucleotides, Antisense Pheromones Pituitary Gland Prolactin Protein Binding Proteins Radioimmunoassay Receptors, Dopamine D2 Social Dominance Territoriality Tritium Competition between adult males for limited resources such as food and receptive females is shaped by the male pattern of pituitary growth hormone (GH) secretion that determines body size and the production of urinary pheromones involved in male-to-male aggression. In the brain, dopamine (DA) provides incentive salience to stimuli that predict the availability of food and sexual partners. Although the importance of the GH axis and central DA neurotransmission in social dominance and fitness is clearly appreciated, the two systems have always been studied unconnectedly. Here we conducted a cell-specific genetic dissection study in conditional mutant mice that selectively lack DA D2 receptors (D2R) from pituitary lactotropes (lacDrd2KO) or neurons (neuroDrd2KO). Whereas lacDrd2KO mice developed a normal GH axis, neuroDrd2KO mice displayed fewer somatotropes; reduced hypothalamic Ghrh expression, pituitary GH content, and serum IGF-I levels; and exhibited reduced body size and weight. As a consequence of a GH axis deficit, neuroDrd2KO adult males excreted low levels of major urinary proteins and their urine failed to promote aggression and territorial behavior in control male challengers, in contrast to the urine taken from control adult males. These findings reveal that central D2Rs mediate a neuroendocrineexocrine cascade that controls the maturation of the GH axis and downstream signals that are critical for fitness, social dominance, and competition between adult males. © 2013 the authors. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v33_n13_p5834_Noain http://hdl.handle.net/20.500.12110/paper_02706474_v33_n13_p5834_Noain |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
dopamine dopamine 2 receptor growth hormone pheromone prolactin somatomedin C receptor animal experiment animal tissue article autoradiography behavior body growth body size body weight controlled study female fitness food intake immunofluorescence test in situ hybridization male motor unit potential mouse neurotransmission nonhuman priority journal radioimmunoassay real time polymerase chain reaction signal transduction social dominance Analysis of Variance Animals Benzamides Body Size Body Weight Case-Control Studies Catatonia Dopamine Antagonists Eating Female Growth Hormone Haloperidol Insulin-Like Growth Factor I Intermediate Filament Proteins Male Mice Mice, Inbred C57BL Mice, Transgenic Nerve Tissue Proteins Oligodeoxyribonucleotides, Antisense Pheromones Pituitary Gland Prolactin Protein Binding Proteins Radioimmunoassay Receptors, Dopamine D2 Social Dominance Territoriality Tritium |
| spellingShingle |
dopamine dopamine 2 receptor growth hormone pheromone prolactin somatomedin C receptor animal experiment animal tissue article autoradiography behavior body growth body size body weight controlled study female fitness food intake immunofluorescence test in situ hybridization male motor unit potential mouse neurotransmission nonhuman priority journal radioimmunoassay real time polymerase chain reaction signal transduction social dominance Analysis of Variance Animals Benzamides Body Size Body Weight Case-Control Studies Catatonia Dopamine Antagonists Eating Female Growth Hormone Haloperidol Insulin-Like Growth Factor I Intermediate Filament Proteins Male Mice Mice, Inbred C57BL Mice, Transgenic Nerve Tissue Proteins Oligodeoxyribonucleotides, Antisense Pheromones Pituitary Gland Prolactin Protein Binding Proteins Radioimmunoassay Receptors, Dopamine D2 Social Dominance Territoriality Tritium Central dopamine D2 receptors regulate growth-hormone- dependent body growth and pheromone signaling to conspecific males |
| topic_facet |
dopamine dopamine 2 receptor growth hormone pheromone prolactin somatomedin C receptor animal experiment animal tissue article autoradiography behavior body growth body size body weight controlled study female fitness food intake immunofluorescence test in situ hybridization male motor unit potential mouse neurotransmission nonhuman priority journal radioimmunoassay real time polymerase chain reaction signal transduction social dominance Analysis of Variance Animals Benzamides Body Size Body Weight Case-Control Studies Catatonia Dopamine Antagonists Eating Female Growth Hormone Haloperidol Insulin-Like Growth Factor I Intermediate Filament Proteins Male Mice Mice, Inbred C57BL Mice, Transgenic Nerve Tissue Proteins Oligodeoxyribonucleotides, Antisense Pheromones Pituitary Gland Prolactin Protein Binding Proteins Radioimmunoassay Receptors, Dopamine D2 Social Dominance Territoriality Tritium |
| description |
Competition between adult males for limited resources such as food and receptive females is shaped by the male pattern of pituitary growth hormone (GH) secretion that determines body size and the production of urinary pheromones involved in male-to-male aggression. In the brain, dopamine (DA) provides incentive salience to stimuli that predict the availability of food and sexual partners. Although the importance of the GH axis and central DA neurotransmission in social dominance and fitness is clearly appreciated, the two systems have always been studied unconnectedly. Here we conducted a cell-specific genetic dissection study in conditional mutant mice that selectively lack DA D2 receptors (D2R) from pituitary lactotropes (lacDrd2KO) or neurons (neuroDrd2KO). Whereas lacDrd2KO mice developed a normal GH axis, neuroDrd2KO mice displayed fewer somatotropes; reduced hypothalamic Ghrh expression, pituitary GH content, and serum IGF-I levels; and exhibited reduced body size and weight. As a consequence of a GH axis deficit, neuroDrd2KO adult males excreted low levels of major urinary proteins and their urine failed to promote aggression and territorial behavior in control male challengers, in contrast to the urine taken from control adult males. These findings reveal that central D2Rs mediate a neuroendocrineexocrine cascade that controls the maturation of the GH axis and downstream signals that are critical for fitness, social dominance, and competition between adult males. © 2013 the authors. |
| title |
Central dopamine D2 receptors regulate growth-hormone- dependent body growth and pheromone signaling to conspecific males |
| title_short |
Central dopamine D2 receptors regulate growth-hormone- dependent body growth and pheromone signaling to conspecific males |
| title_full |
Central dopamine D2 receptors regulate growth-hormone- dependent body growth and pheromone signaling to conspecific males |
| title_fullStr |
Central dopamine D2 receptors regulate growth-hormone- dependent body growth and pheromone signaling to conspecific males |
| title_full_unstemmed |
Central dopamine D2 receptors regulate growth-hormone- dependent body growth and pheromone signaling to conspecific males |
| title_sort |
central dopamine d2 receptors regulate growth-hormone- dependent body growth and pheromone signaling to conspecific males |
| publishDate |
2013 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v33_n13_p5834_Noain http://hdl.handle.net/20.500.12110/paper_02706474_v33_n13_p5834_Noain |
| _version_ |
1768543083026186240 |