Associative conditioning tunes transient dynamics of early olfactory processing
Odors evoke complex spatiotemporal responses in the insect antennal lobe (AL) and mammalian olfactory bulb. However, the behavioral relevance of spatiotemporal coding remains unclear. In the present work we combined behavioral analyses with calcium imaging of odor induced activity in the honeybee AL...
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2009
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v29_n33_p10191_Fernandez http://hdl.handle.net/20.500.12110/paper_02706474_v29_n33_p10191_Fernandez |
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paper:paper_02706474_v29_n33_p10191_Fernandez2023-06-08T15:24:47Z Associative conditioning tunes transient dynamics of early olfactory processing 2 octanol hexanol animal experiment article behavioral science controlled study honeybee nonhuman odor olfactory discrimination olfactory memory priority journal reinforcement smelling state dependent learning stimulus response temporal lobe Animals Association Learning Bees Conditioning (Psychology) Odors Olfactory Pathways Reaction Time Smell Time Factors Odors evoke complex spatiotemporal responses in the insect antennal lobe (AL) and mammalian olfactory bulb. However, the behavioral relevance of spatiotemporal coding remains unclear. In the present work we combined behavioral analyses with calcium imaging of odor induced activity in the honeybee AL to evaluate the relevance of this temporal dimension in the olfactory code. We used a new way for evaluation of odor similarity of binary mixtures in behavioral studies, which involved testing whether a match of odor-sampling time is necessary between training and testing conditions for odor recognition during associative learning. Using graded changes in the similarity of the mixture ratios, we found high correlations between the behavioral generalization across those mixtures and a gradient of activation in AL output. Furthermore, short odor stimuli of 500 ms or less affected how well odors were matched with a memory template, and this time corresponded to a shift from a sampling-time-dependent to a sampling-time-independent memory. Accordingly, 375 ms corresponded to the time required for spatiotemporal AL activity patterns to reach maximal separation according to imaging studies. Finally, we compared spatiotemporal representations of binary mixtures in trained and untrained animals. AL activity was modified by conditioning to improve separation of odor representations. These data suggest that one role of reinforcement is to "tune" the AL such that relevant odors become more discriminable. Copyright © 2009 Society for Neuroscience. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v29_n33_p10191_Fernandez http://hdl.handle.net/20.500.12110/paper_02706474_v29_n33_p10191_Fernandez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
2 octanol hexanol animal experiment article behavioral science controlled study honeybee nonhuman odor olfactory discrimination olfactory memory priority journal reinforcement smelling state dependent learning stimulus response temporal lobe Animals Association Learning Bees Conditioning (Psychology) Odors Olfactory Pathways Reaction Time Smell Time Factors |
| spellingShingle |
2 octanol hexanol animal experiment article behavioral science controlled study honeybee nonhuman odor olfactory discrimination olfactory memory priority journal reinforcement smelling state dependent learning stimulus response temporal lobe Animals Association Learning Bees Conditioning (Psychology) Odors Olfactory Pathways Reaction Time Smell Time Factors Associative conditioning tunes transient dynamics of early olfactory processing |
| topic_facet |
2 octanol hexanol animal experiment article behavioral science controlled study honeybee nonhuman odor olfactory discrimination olfactory memory priority journal reinforcement smelling state dependent learning stimulus response temporal lobe Animals Association Learning Bees Conditioning (Psychology) Odors Olfactory Pathways Reaction Time Smell Time Factors |
| description |
Odors evoke complex spatiotemporal responses in the insect antennal lobe (AL) and mammalian olfactory bulb. However, the behavioral relevance of spatiotemporal coding remains unclear. In the present work we combined behavioral analyses with calcium imaging of odor induced activity in the honeybee AL to evaluate the relevance of this temporal dimension in the olfactory code. We used a new way for evaluation of odor similarity of binary mixtures in behavioral studies, which involved testing whether a match of odor-sampling time is necessary between training and testing conditions for odor recognition during associative learning. Using graded changes in the similarity of the mixture ratios, we found high correlations between the behavioral generalization across those mixtures and a gradient of activation in AL output. Furthermore, short odor stimuli of 500 ms or less affected how well odors were matched with a memory template, and this time corresponded to a shift from a sampling-time-dependent to a sampling-time-independent memory. Accordingly, 375 ms corresponded to the time required for spatiotemporal AL activity patterns to reach maximal separation according to imaging studies. Finally, we compared spatiotemporal representations of binary mixtures in trained and untrained animals. AL activity was modified by conditioning to improve separation of odor representations. These data suggest that one role of reinforcement is to "tune" the AL such that relevant odors become more discriminable. Copyright © 2009 Society for Neuroscience. |
| title |
Associative conditioning tunes transient dynamics of early olfactory processing |
| title_short |
Associative conditioning tunes transient dynamics of early olfactory processing |
| title_full |
Associative conditioning tunes transient dynamics of early olfactory processing |
| title_fullStr |
Associative conditioning tunes transient dynamics of early olfactory processing |
| title_full_unstemmed |
Associative conditioning tunes transient dynamics of early olfactory processing |
| title_sort |
associative conditioning tunes transient dynamics of early olfactory processing |
| publishDate |
2009 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v29_n33_p10191_Fernandez http://hdl.handle.net/20.500.12110/paper_02706474_v29_n33_p10191_Fernandez |
| _version_ |
1768543896902565888 |