Induction of long-term memory by exposure to novelty requires protein synthesis: Evidence for a behavioral tagging
A behavioral analog of the synaptic tagging and capture process, a key property of synaptic plasticity, has been predicted recently. Here, we demonstrate that weak inhibitory avoidance training, which induces short- but not long-term memory (LTM), can be consolidated into LTM by an exploration to a...
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2007
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v27_n28_p7476_Moncada http://hdl.handle.net/20.500.12110/paper_02706474_v27_n28_p7476_Moncada |
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paper:paper_02706474_v27_n28_p7476_Moncada2023-06-08T15:24:46Z Induction of long-term memory by exposure to novelty requires protein synthesis: Evidence for a behavioral tagging Moncada, Diego Viola, Haydée Ana María Behavioral tag Hippocampus Inhibitory avoidance Long-term memory Rats Spatial novelty 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate anisomycin dopamine 1 receptor dopamine 5 receptor animal experiment article behavior controlled study environment exploratory behavior hippocampus long term memory male nonhuman plasticity priority journal protein stability protein synthesis rat training Animals Avoidance Learning Exploratory Behavior Hippocampus Male Memory Nerve Tissue Proteins Neuronal Plasticity Rats Rats, Wistar Receptors, Dopamine D1 Receptors, Dopamine D5 Time Factors A behavioral analog of the synaptic tagging and capture process, a key property of synaptic plasticity, has been predicted recently. Here, we demonstrate that weak inhibitory avoidance training, which induces short- but not long-term memory (LTM), can be consolidated into LTM by an exploration to a novel, but not a familiar, environment occurring close in time to the training session. This memorypromoting effect caused by novelty depends on activation of dopamine D1/D5 receptors and requires newly synthesized proteins in the dorsal hippocampus. Thus, our results indicate the existence of a behavioral tagging process in which the exploration to a novel environment provides the plasticity-related proteins to stabilize the inhibitory avoidance memory trace. Copyright © 2007 Society for Neuroscience. Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v27_n28_p7476_Moncada http://hdl.handle.net/20.500.12110/paper_02706474_v27_n28_p7476_Moncada |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Behavioral tag Hippocampus Inhibitory avoidance Long-term memory Rats Spatial novelty 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate anisomycin dopamine 1 receptor dopamine 5 receptor animal experiment article behavior controlled study environment exploratory behavior hippocampus long term memory male nonhuman plasticity priority journal protein stability protein synthesis rat training Animals Avoidance Learning Exploratory Behavior Hippocampus Male Memory Nerve Tissue Proteins Neuronal Plasticity Rats Rats, Wistar Receptors, Dopamine D1 Receptors, Dopamine D5 Time Factors |
| spellingShingle |
Behavioral tag Hippocampus Inhibitory avoidance Long-term memory Rats Spatial novelty 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate anisomycin dopamine 1 receptor dopamine 5 receptor animal experiment article behavior controlled study environment exploratory behavior hippocampus long term memory male nonhuman plasticity priority journal protein stability protein synthesis rat training Animals Avoidance Learning Exploratory Behavior Hippocampus Male Memory Nerve Tissue Proteins Neuronal Plasticity Rats Rats, Wistar Receptors, Dopamine D1 Receptors, Dopamine D5 Time Factors Moncada, Diego Viola, Haydée Ana María Induction of long-term memory by exposure to novelty requires protein synthesis: Evidence for a behavioral tagging |
| topic_facet |
Behavioral tag Hippocampus Inhibitory avoidance Long-term memory Rats Spatial novelty 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate anisomycin dopamine 1 receptor dopamine 5 receptor animal experiment article behavior controlled study environment exploratory behavior hippocampus long term memory male nonhuman plasticity priority journal protein stability protein synthesis rat training Animals Avoidance Learning Exploratory Behavior Hippocampus Male Memory Nerve Tissue Proteins Neuronal Plasticity Rats Rats, Wistar Receptors, Dopamine D1 Receptors, Dopamine D5 Time Factors |
| description |
A behavioral analog of the synaptic tagging and capture process, a key property of synaptic plasticity, has been predicted recently. Here, we demonstrate that weak inhibitory avoidance training, which induces short- but not long-term memory (LTM), can be consolidated into LTM by an exploration to a novel, but not a familiar, environment occurring close in time to the training session. This memorypromoting effect caused by novelty depends on activation of dopamine D1/D5 receptors and requires newly synthesized proteins in the dorsal hippocampus. Thus, our results indicate the existence of a behavioral tagging process in which the exploration to a novel environment provides the plasticity-related proteins to stabilize the inhibitory avoidance memory trace. Copyright © 2007 Society for Neuroscience. |
| author |
Moncada, Diego Viola, Haydée Ana María |
| author_facet |
Moncada, Diego Viola, Haydée Ana María |
| author_sort |
Moncada, Diego |
| title |
Induction of long-term memory by exposure to novelty requires protein synthesis: Evidence for a behavioral tagging |
| title_short |
Induction of long-term memory by exposure to novelty requires protein synthesis: Evidence for a behavioral tagging |
| title_full |
Induction of long-term memory by exposure to novelty requires protein synthesis: Evidence for a behavioral tagging |
| title_fullStr |
Induction of long-term memory by exposure to novelty requires protein synthesis: Evidence for a behavioral tagging |
| title_full_unstemmed |
Induction of long-term memory by exposure to novelty requires protein synthesis: Evidence for a behavioral tagging |
| title_sort |
induction of long-term memory by exposure to novelty requires protein synthesis: evidence for a behavioral tagging |
| publishDate |
2007 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v27_n28_p7476_Moncada http://hdl.handle.net/20.500.12110/paper_02706474_v27_n28_p7476_Moncada |
| work_keys_str_mv |
AT moncadadiego inductionoflongtermmemorybyexposuretonoveltyrequiresproteinsynthesisevidenceforabehavioraltagging AT violahaydeeanamaria inductionoflongtermmemorybyexposuretonoveltyrequiresproteinsynthesisevidenceforabehavioraltagging |
| _version_ |
1768545830575276032 |