Identification, characterization and subcellular localization of TcPDE1, a novel cAMP-specific phosphodiesterase from Trypanosoma cruzi

Compartmentalization of cAMP phosphodiesterases plays a key role in the regulation of cAMP signalling in mammals. In the present paper, we report the characterization and subcellular localization of TcPDE1, the first cAMP-specific phosphodiesterase to be identified from Trypanosoma cruzi. TcPDE1 is...

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Detalles Bibliográficos
Publicado:	2004
Materias:	cAMP Flagellum Membrane Phosphodiesterase Trypanosoma cruzi Biological membranes Enzyme inhibition Enzymes Genes Hydrochloric acid Yeast Cell disruption Mutants Biochemistry 9 (2 hydroxy 3 nonyl)adenine amino acid calcium channel blocking agent calmodulin inhibitor chloride cyclic AMP cyclic AMP phosphodiesterase cyclic AMP phosphodiesterase 1 cyclic GMP dipyridamole enzyme isobutylmethylxanthine membrane protein papaverine phosphodiesterase phosphodiesterase inhibitor protein inhibitor protein subunit recombinant protein rolipram sodium chloride theophylline unclassified drug vinpocetine zaprinast article cell disruption cell fractionation cell membrane cell organelle cellular distribution chemosensitivity confocal laser microscopy controlled study enzyme activity enzyme localization enzyme specificity epimastigote flagellum genetic code heat shock membrane multigene family nonhuman nucleotide sequence parasite priority journal protein analysis protein deficiency protein secretion temperature sensitive mutant Trypanosoma yeast 3',5'-Cyclic-Nucleotide Phosphodiesterase Amino Acid Sequence Animals Cell Membrane Cloning, Molecular Flagella Gene Components Genetic Complementation Test Microscopy, Confocal Molecular Sequence Data Subcellular Fractions Yeasts Mammalia Protozoa Trypanosomatidae
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02646021_v378_n1_p63_DAngelo http://hdl.handle.net/20.500.12110/paper_02646021_v378_n1_p63_DAngelo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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