A DNA topoisomerase i inhibitor blocks the differentiation of rat granulosa cells induced by follicle-stimulating hormone

Follicle-stimulating hormone (FSH), acting through a cyclic AMP-mediated mechanism, promotes differentiation of rat granulosa cells cultured in a defined medium. Camptothecin, a DNA topoisomerase I blocker, inhibited the increase in progesterone and oestradiol production stimulated by FSH. This effe...

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Detalles Bibliográficos
Publicado: 1991
Materias:
bucladesine
camptothecin
cell extract
DNA topoisomerase
estradiol
follitropin
progesterone
diethylstilbestrol
insulin
methionine
animal cell
animal cell culture
Article
cell differentiation
comparative study
controlled study
enzyme activity
enzyme assay
female
granulosa cell
hormone synthesis
nonhuman
priority journal
protein synthesis
rat
animal
article
cell culture
cytology
drug antagonism
drug effect
enzymology
kinetics
metabolism
rat strain
DNA synthesis
gene expression regulation
hormonal regulation
topical drug administration
Animals
Bucladesine
Camptothecin
Cell Differentiation
Cells, Cultured
Diethylstilbestrol
DNA Topoisomerases, Type I
Female
Follicle Stimulating Hormone
Granulosa Cells
Insulin
Kinetics
Methionine
Protein Biosynthesis
Rats
Rats, Inbred Strains
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02646021_v277_n2_p557_Baranao
http://hdl.handle.net/20.500.12110/paper_02646021_v277_n2_p557_Baranao
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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