New monitoring software for larger clinical application of brachial artery flow-mediated vasodilatation measurements

BACKGROUND: The reproducibility of brachial artery flow-mediated vasodilatation (FMD) is limited by the operator dependence of most measurement methods. METHODS: A new automated computerized analysis of brachial artery ultrasound scan providing a continuous evolution of the diameter during acute hyp...

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Publicado:	2007
Materias:	Brachial artery Endothelium Ultrasound Vasodilatation adult article automation B scan brachial artery brachial artery flow mediated vasodilation cardiovascular risk clinical article computer analysis computer program controlled study female forearm hand human hypercholesterolemia hyperemia hypertension ischemic heart disease male measurement metabolic syndrome X monitoring priority journal reproducibility smoking ultrasound vasodilatation Adult Blood Flow Velocity Brachial Artery Cardiovascular Diseases Female Humans Hypercholesterolemia Hyperemia Hypertension Image Interpretation, Computer-Assisted Male Metabolic Syndrome X Observer Variation Reference Values Reproducibility of Results Research Design Risk Factors Smoking Software Time Factors Vasodilation
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02636352_v25_n1_p133_Craiem http://hdl.handle.net/20.500.12110/paper_02636352_v25_n1_p133_Craiem
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_02636352_v25_n1_p133_Craiem
record_format	dspace
spelling	paper:paper_02636352_v25_n1_p133_Craiem2023-06-08T15:22:55Z New monitoring software for larger clinical application of brachial artery flow-mediated vasodilatation measurements Brachial artery Endothelium Ultrasound Vasodilatation adult article automation B scan brachial artery brachial artery flow mediated vasodilation cardiovascular risk clinical article computer analysis computer program controlled study female forearm hand human hypercholesterolemia hyperemia hypertension ischemic heart disease male measurement metabolic syndrome X monitoring priority journal reproducibility smoking ultrasound vasodilatation Adult Blood Flow Velocity Brachial Artery Cardiovascular Diseases Female Humans Hypercholesterolemia Hyperemia Hypertension Image Interpretation, Computer-Assisted Male Metabolic Syndrome X Observer Variation Reference Values Reproducibility of Results Research Design Risk Factors Smoking Software Time Factors Vasodilation BACKGROUND: The reproducibility of brachial artery flow-mediated vasodilatation (FMD) is limited by the operator dependence of most measurement methods. METHODS: A new automated computerized analysis of brachial artery ultrasound scan providing a continuous evolution of the diameter during acute hyperemia, reactive to short hyperemia of the foream and hand, was tested in 10 normal volunteers and 26 asymptomatic patients with cardiovascular risk factors such as hypertension, hypercholesterolemia, heavy smoking, history of premature coronary heart disease and the metabolic syndrome. FMD was the percentage of the maximum hyperemic diastolic diameter from baseline. Within-reading variations in FMD and diameters were assessed by reading one scan from the same subject twice by two observers. The within-subject variability of FMD was assessed by analysing two repeated measurements in the same subject by the same operator 1 h, 1 week or 1 month apart. RESULTS: Coefficients of variation (CV) of repeated FMD readings were 7.5% in normal volunteers and 6.9% in patients with risk factors. CV of repeated FMD measurements 1 h apart were 7.8% in normal volunteers and 16.5% in patients with risk factors. In normal volunteers, CV of repeated FMD measurements 1 week apart was 9.6%, and in patients with risk factors CV of repeated FMD measurement 1 month apart was 18.1%. CONCLUSION: This method overcomes the variability of FMD measurement seen with conventional manual analysis in normal volunteers, and to a lesser extent in patients with major cardiovascular risk factors, thus supporting its clinical applicability to patients with disease conditions. © 2007 Lippincott Williams & Wilkins, Inc. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02636352_v25_n1_p133_Craiem http://hdl.handle.net/20.500.12110/paper_02636352_v25_n1_p133_Craiem
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Brachial artery Endothelium Ultrasound Vasodilatation adult article automation B scan brachial artery brachial artery flow mediated vasodilation cardiovascular risk clinical article computer analysis computer program controlled study female forearm hand human hypercholesterolemia hyperemia hypertension ischemic heart disease male measurement metabolic syndrome X monitoring priority journal reproducibility smoking ultrasound vasodilatation Adult Blood Flow Velocity Brachial Artery Cardiovascular Diseases Female Humans Hypercholesterolemia Hyperemia Hypertension Image Interpretation, Computer-Assisted Male Metabolic Syndrome X Observer Variation Reference Values Reproducibility of Results Research Design Risk Factors Smoking Software Time Factors Vasodilation
spellingShingle	Brachial artery Endothelium Ultrasound Vasodilatation adult article automation B scan brachial artery brachial artery flow mediated vasodilation cardiovascular risk clinical article computer analysis computer program controlled study female forearm hand human hypercholesterolemia hyperemia hypertension ischemic heart disease male measurement metabolic syndrome X monitoring priority journal reproducibility smoking ultrasound vasodilatation Adult Blood Flow Velocity Brachial Artery Cardiovascular Diseases Female Humans Hypercholesterolemia Hyperemia Hypertension Image Interpretation, Computer-Assisted Male Metabolic Syndrome X Observer Variation Reference Values Reproducibility of Results Research Design Risk Factors Smoking Software Time Factors Vasodilation New monitoring software for larger clinical application of brachial artery flow-mediated vasodilatation measurements
topic_facet	Brachial artery Endothelium Ultrasound Vasodilatation adult article automation B scan brachial artery brachial artery flow mediated vasodilation cardiovascular risk clinical article computer analysis computer program controlled study female forearm hand human hypercholesterolemia hyperemia hypertension ischemic heart disease male measurement metabolic syndrome X monitoring priority journal reproducibility smoking ultrasound vasodilatation Adult Blood Flow Velocity Brachial Artery Cardiovascular Diseases Female Humans Hypercholesterolemia Hyperemia Hypertension Image Interpretation, Computer-Assisted Male Metabolic Syndrome X Observer Variation Reference Values Reproducibility of Results Research Design Risk Factors Smoking Software Time Factors Vasodilation
description	BACKGROUND: The reproducibility of brachial artery flow-mediated vasodilatation (FMD) is limited by the operator dependence of most measurement methods. METHODS: A new automated computerized analysis of brachial artery ultrasound scan providing a continuous evolution of the diameter during acute hyperemia, reactive to short hyperemia of the foream and hand, was tested in 10 normal volunteers and 26 asymptomatic patients with cardiovascular risk factors such as hypertension, hypercholesterolemia, heavy smoking, history of premature coronary heart disease and the metabolic syndrome. FMD was the percentage of the maximum hyperemic diastolic diameter from baseline. Within-reading variations in FMD and diameters were assessed by reading one scan from the same subject twice by two observers. The within-subject variability of FMD was assessed by analysing two repeated measurements in the same subject by the same operator 1 h, 1 week or 1 month apart. RESULTS: Coefficients of variation (CV) of repeated FMD readings were 7.5% in normal volunteers and 6.9% in patients with risk factors. CV of repeated FMD measurements 1 h apart were 7.8% in normal volunteers and 16.5% in patients with risk factors. In normal volunteers, CV of repeated FMD measurements 1 week apart was 9.6%, and in patients with risk factors CV of repeated FMD measurement 1 month apart was 18.1%. CONCLUSION: This method overcomes the variability of FMD measurement seen with conventional manual analysis in normal volunteers, and to a lesser extent in patients with major cardiovascular risk factors, thus supporting its clinical applicability to patients with disease conditions. © 2007 Lippincott Williams & Wilkins, Inc.
title	New monitoring software for larger clinical application of brachial artery flow-mediated vasodilatation measurements
title_short	New monitoring software for larger clinical application of brachial artery flow-mediated vasodilatation measurements
title_full	New monitoring software for larger clinical application of brachial artery flow-mediated vasodilatation measurements
title_fullStr	New monitoring software for larger clinical application of brachial artery flow-mediated vasodilatation measurements
title_full_unstemmed	New monitoring software for larger clinical application of brachial artery flow-mediated vasodilatation measurements
title_sort	new monitoring software for larger clinical application of brachial artery flow-mediated vasodilatation measurements
publishDate	2007
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02636352_v25_n1_p133_Craiem http://hdl.handle.net/20.500.12110/paper_02636352_v25_n1_p133_Craiem
_version_	1768543750400770048

New monitoring software for larger clinical application of brachial artery flow-mediated vasodilatation measurements

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