Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectiomized animals
The influence of prostaglandins (PGs) on the metabolism of 3H-noradrenaline in isolated uterine, horns from ovariectomized rats exposed to acetylsalicylic acid was explored. PGE1 and PGE2 (10 nM) increased both the total tritium and the 3H-O-methylated deaminated metabolites from the spontaneous out...
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1982
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v9_n3_p341_FernandezPardal http://hdl.handle.net/20.500.12110/paper_02621746_v9_n3_p341_FernandezPardal |
| Aporte de: |
| Sumario: | The influence of prostaglandins (PGs) on the metabolism of 3H-noradrenaline in isolated uterine, horns from ovariectomized rats exposed to acetylsalicylic acid was explored. PGE1 and PGE2 (10 nM) increased both the total tritium and the 3H-O-methylated deaminated metabolites from the spontaneous outflow. PGE2 augmented 3H-normetanephrine whereas PGE1 reduced the 3H-3,4-dihydroxyphenylglycol fraction. The 3H-noradrenaline fraction from the spontaneous outflow of tritium was enhanced by PGE2 and PGI2 (10 nM). On the other hand PGF2α (10 nM-1 uM) did not change the metabolism of 3H-noradrenaline. The present findings suggest a possible modulation of noradrenaline metabolism by some PGs on the isolated rat uterus from ovariectomized rats. © 1982 Longman Group Ltd. |
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