Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectiomized animals
The influence of prostaglandins (PGs) on the metabolism of 3H-noradrenaline in isolated uterine, horns from ovariectomized rats exposed to acetylsalicylic acid was explored. PGE1 and PGE2 (10 nM) increased both the total tritium and the 3H-O-methylated deaminated metabolites from the spontaneous out...
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1982
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v9_n3_p341_FernandezPardal http://hdl.handle.net/20.500.12110/paper_02621746_v9_n3_p341_FernandezPardal |
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paper:paper_02621746_v9_n3_p341_FernandezPardal |
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paper:paper_02621746_v9_n3_p341_FernandezPardal2023-06-08T15:22:53Z Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectiomized animals 3,4 dihydroxyphenylethylene glycol 4 hydroxy 3 methoxyphenylethylene glycol drug derivative noradrenalin normetadrenalin prostacyclin prostaglandin prostaglandin E prostaglandin E1 prostaglandin E2 acetylsalicylic acid alpha adrenergic receptor noradrenalin prostacyclin prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha radioisotope animal article castration drug effect female in vitro study metabolism methylation rat rat strain uterus animal experiment autonomic nervous system drug metabolism endocrine system female genital system noradrenalin h 3 ovariectomy uterus Alprostadil Animal Castration Dinoprostone Epoprostenol Female In Vitro Methoxyhydroxyphenylglycol Methylation Norepinephrine Normetanephrine Prostaglandins Prostaglandins E Rats Rats, Inbred Strains Uterus The influence of prostaglandins (PGs) on the metabolism of 3H-noradrenaline in isolated uterine, horns from ovariectomized rats exposed to acetylsalicylic acid was explored. PGE1 and PGE2 (10 nM) increased both the total tritium and the 3H-O-methylated deaminated metabolites from the spontaneous outflow. PGE2 augmented 3H-normetanephrine whereas PGE1 reduced the 3H-3,4-dihydroxyphenylglycol fraction. The 3H-noradrenaline fraction from the spontaneous outflow of tritium was enhanced by PGE2 and PGI2 (10 nM). On the other hand PGF2α (10 nM-1 uM) did not change the metabolism of 3H-noradrenaline. The present findings suggest a possible modulation of noradrenaline metabolism by some PGs on the isolated rat uterus from ovariectomized rats. © 1982 Longman Group Ltd. 1982 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v9_n3_p341_FernandezPardal http://hdl.handle.net/20.500.12110/paper_02621746_v9_n3_p341_FernandezPardal |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
3,4 dihydroxyphenylethylene glycol 4 hydroxy 3 methoxyphenylethylene glycol drug derivative noradrenalin normetadrenalin prostacyclin prostaglandin prostaglandin E prostaglandin E1 prostaglandin E2 acetylsalicylic acid alpha adrenergic receptor noradrenalin prostacyclin prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha radioisotope animal article castration drug effect female in vitro study metabolism methylation rat rat strain uterus animal experiment autonomic nervous system drug metabolism endocrine system female genital system noradrenalin h 3 ovariectomy uterus Alprostadil Animal Castration Dinoprostone Epoprostenol Female In Vitro Methoxyhydroxyphenylglycol Methylation Norepinephrine Normetanephrine Prostaglandins Prostaglandins E Rats Rats, Inbred Strains Uterus |
| spellingShingle |
3,4 dihydroxyphenylethylene glycol 4 hydroxy 3 methoxyphenylethylene glycol drug derivative noradrenalin normetadrenalin prostacyclin prostaglandin prostaglandin E prostaglandin E1 prostaglandin E2 acetylsalicylic acid alpha adrenergic receptor noradrenalin prostacyclin prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha radioisotope animal article castration drug effect female in vitro study metabolism methylation rat rat strain uterus animal experiment autonomic nervous system drug metabolism endocrine system female genital system noradrenalin h 3 ovariectomy uterus Alprostadil Animal Castration Dinoprostone Epoprostenol Female In Vitro Methoxyhydroxyphenylglycol Methylation Norepinephrine Normetanephrine Prostaglandins Prostaglandins E Rats Rats, Inbred Strains Uterus Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectiomized animals |
| topic_facet |
3,4 dihydroxyphenylethylene glycol 4 hydroxy 3 methoxyphenylethylene glycol drug derivative noradrenalin normetadrenalin prostacyclin prostaglandin prostaglandin E prostaglandin E1 prostaglandin E2 acetylsalicylic acid alpha adrenergic receptor noradrenalin prostacyclin prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha radioisotope animal article castration drug effect female in vitro study metabolism methylation rat rat strain uterus animal experiment autonomic nervous system drug metabolism endocrine system female genital system noradrenalin h 3 ovariectomy uterus Alprostadil Animal Castration Dinoprostone Epoprostenol Female In Vitro Methoxyhydroxyphenylglycol Methylation Norepinephrine Normetanephrine Prostaglandins Prostaglandins E Rats Rats, Inbred Strains Uterus |
| description |
The influence of prostaglandins (PGs) on the metabolism of 3H-noradrenaline in isolated uterine, horns from ovariectomized rats exposed to acetylsalicylic acid was explored. PGE1 and PGE2 (10 nM) increased both the total tritium and the 3H-O-methylated deaminated metabolites from the spontaneous outflow. PGE2 augmented 3H-normetanephrine whereas PGE1 reduced the 3H-3,4-dihydroxyphenylglycol fraction. The 3H-noradrenaline fraction from the spontaneous outflow of tritium was enhanced by PGE2 and PGI2 (10 nM). On the other hand PGF2α (10 nM-1 uM) did not change the metabolism of 3H-noradrenaline. The present findings suggest a possible modulation of noradrenaline metabolism by some PGs on the isolated rat uterus from ovariectomized rats. © 1982 Longman Group Ltd. |
| title |
Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectiomized animals |
| title_short |
Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectiomized animals |
| title_full |
Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectiomized animals |
| title_fullStr |
Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectiomized animals |
| title_full_unstemmed |
Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectiomized animals |
| title_sort |
prostaglandins alter the 3h-noradrenaline metabolism by the isolated rat uterus from ovariectiomized animals |
| publishDate |
1982 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v9_n3_p341_FernandezPardal http://hdl.handle.net/20.500.12110/paper_02621746_v9_n3_p341_FernandezPardal |
| _version_ |
1768546490595147776 |