On the inotropic effects of leukotrienes in the isolated urinary bladder of guinea pigs and rats
Leukotrienes (LTs) B4, C4 and D4 were tested on the motility of rings isolated from the urinary bladder of guinea pigs and rats. LTB4 did not evoke inotropic influences in any of the preparations, whereas LTC4 and LTD4 augmented the magnitudes of tonic and phasic contractions in the guinea pig but n...
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1985
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v20_n1_p89_Viggiano http://hdl.handle.net/20.500.12110/paper_02621746_v20_n1_p89_Viggiano |
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paper:paper_02621746_v20_n1_p89_Viggiano2023-06-08T15:22:52Z On the inotropic effects of leukotrienes in the isolated urinary bladder of guinea pigs and rats 7 [3 (4 acetyl 3 hydroxy 2 propylphenoxy) 2 hydroxypropoxy] 4 oxo 8 propyl 4h 1 benzopyran 2 carboxylic acid acetylsalicylic acid leukotriene leukotriene b4 leukotriene c4 leukotriene d4 nordihydroguaiaretic acid animal cell bladder contraction detrusor muscle dose response drug administration drug comparison drug efficacy drug response guinea pig in vitro study inotropism muscle nonhuman preliminary communication priority journal rat smooth muscle contraction Animal Aspirin Bladder Catechols Comparative Study Guinea Pigs In Vitro Leukotriene B4 Male Muscle Contraction Nordihydroguaiaretic Acid Rats Rats, Inbred Strains SRS-A Support, Non-U.S. Gov't Leukotrienes (LTs) B4, C4 and D4 were tested on the motility of rings isolated from the urinary bladder of guinea pigs and rats. LTB4 did not evoke inotropic influences in any of the preparations, whereas LTC4 and LTD4 augmented the magnitudes of tonic and phasic contractions in the guinea pig but not in the rat detrusor muscle, LTC4 evoking a greater enhancement than LTD4. On molar bases, acetylcholine induced smaller positive inotropic effects. In the presence of 10-4 M acetylsalicylic acid (ASA), cumulative dose-response curves of phasic and tonic: contractions for LTC4 were shifted to the right of controls, whereas curves of the phasic motility for LTD4 remained unaltered. However, ASA shifted to the left the dose-response curve of tonic contractions for LTD4 and in addition evoked an augmentation of the absolute developed tension. The initial (postequilibrium) contractile levels of basal phasic contractions did not differ between controls and preparations incubated with ASA (10-4 M), nordihydroguaiaretic acid (10-7 M) or FPL-55712 (3×10-6 M). The findings suggest that some musculo-active prostanoid(s) could be modulating, in opposite directions, the smooth muscle contractile reactivity of the guinea pig urinary bladder when challenged in vitro with LTC4 and LTD4. Our data reported hereing also suggest that the role, if any, of endogenous prostanoids and leukotrienes for the normal basal contractile functioning of the guinea pig urinary bladder, remains obscure. © 1985. 1985 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v20_n1_p89_Viggiano http://hdl.handle.net/20.500.12110/paper_02621746_v20_n1_p89_Viggiano |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
7 [3 (4 acetyl 3 hydroxy 2 propylphenoxy) 2 hydroxypropoxy] 4 oxo 8 propyl 4h 1 benzopyran 2 carboxylic acid acetylsalicylic acid leukotriene leukotriene b4 leukotriene c4 leukotriene d4 nordihydroguaiaretic acid animal cell bladder contraction detrusor muscle dose response drug administration drug comparison drug efficacy drug response guinea pig in vitro study inotropism muscle nonhuman preliminary communication priority journal rat smooth muscle contraction Animal Aspirin Bladder Catechols Comparative Study Guinea Pigs In Vitro Leukotriene B4 Male Muscle Contraction Nordihydroguaiaretic Acid Rats Rats, Inbred Strains SRS-A Support, Non-U.S. Gov't |
| spellingShingle |
7 [3 (4 acetyl 3 hydroxy 2 propylphenoxy) 2 hydroxypropoxy] 4 oxo 8 propyl 4h 1 benzopyran 2 carboxylic acid acetylsalicylic acid leukotriene leukotriene b4 leukotriene c4 leukotriene d4 nordihydroguaiaretic acid animal cell bladder contraction detrusor muscle dose response drug administration drug comparison drug efficacy drug response guinea pig in vitro study inotropism muscle nonhuman preliminary communication priority journal rat smooth muscle contraction Animal Aspirin Bladder Catechols Comparative Study Guinea Pigs In Vitro Leukotriene B4 Male Muscle Contraction Nordihydroguaiaretic Acid Rats Rats, Inbred Strains SRS-A Support, Non-U.S. Gov't On the inotropic effects of leukotrienes in the isolated urinary bladder of guinea pigs and rats |
| topic_facet |
7 [3 (4 acetyl 3 hydroxy 2 propylphenoxy) 2 hydroxypropoxy] 4 oxo 8 propyl 4h 1 benzopyran 2 carboxylic acid acetylsalicylic acid leukotriene leukotriene b4 leukotriene c4 leukotriene d4 nordihydroguaiaretic acid animal cell bladder contraction detrusor muscle dose response drug administration drug comparison drug efficacy drug response guinea pig in vitro study inotropism muscle nonhuman preliminary communication priority journal rat smooth muscle contraction Animal Aspirin Bladder Catechols Comparative Study Guinea Pigs In Vitro Leukotriene B4 Male Muscle Contraction Nordihydroguaiaretic Acid Rats Rats, Inbred Strains SRS-A Support, Non-U.S. Gov't |
| description |
Leukotrienes (LTs) B4, C4 and D4 were tested on the motility of rings isolated from the urinary bladder of guinea pigs and rats. LTB4 did not evoke inotropic influences in any of the preparations, whereas LTC4 and LTD4 augmented the magnitudes of tonic and phasic contractions in the guinea pig but not in the rat detrusor muscle, LTC4 evoking a greater enhancement than LTD4. On molar bases, acetylcholine induced smaller positive inotropic effects. In the presence of 10-4 M acetylsalicylic acid (ASA), cumulative dose-response curves of phasic and tonic: contractions for LTC4 were shifted to the right of controls, whereas curves of the phasic motility for LTD4 remained unaltered. However, ASA shifted to the left the dose-response curve of tonic contractions for LTD4 and in addition evoked an augmentation of the absolute developed tension. The initial (postequilibrium) contractile levels of basal phasic contractions did not differ between controls and preparations incubated with ASA (10-4 M), nordihydroguaiaretic acid (10-7 M) or FPL-55712 (3×10-6 M). The findings suggest that some musculo-active prostanoid(s) could be modulating, in opposite directions, the smooth muscle contractile reactivity of the guinea pig urinary bladder when challenged in vitro with LTC4 and LTD4. Our data reported hereing also suggest that the role, if any, of endogenous prostanoids and leukotrienes for the normal basal contractile functioning of the guinea pig urinary bladder, remains obscure. © 1985. |
| title |
On the inotropic effects of leukotrienes in the isolated urinary bladder of guinea pigs and rats |
| title_short |
On the inotropic effects of leukotrienes in the isolated urinary bladder of guinea pigs and rats |
| title_full |
On the inotropic effects of leukotrienes in the isolated urinary bladder of guinea pigs and rats |
| title_fullStr |
On the inotropic effects of leukotrienes in the isolated urinary bladder of guinea pigs and rats |
| title_full_unstemmed |
On the inotropic effects of leukotrienes in the isolated urinary bladder of guinea pigs and rats |
| title_sort |
on the inotropic effects of leukotrienes in the isolated urinary bladder of guinea pigs and rats |
| publishDate |
1985 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v20_n1_p89_Viggiano http://hdl.handle.net/20.500.12110/paper_02621746_v20_n1_p89_Viggiano |
| _version_ |
1768542736527392768 |