Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients

The influences of arachidonic acid (AA) and of inhibitors of lipoxygenases (eicosetetraynoic acid-ETYA- and nordihydrogusiaretic acid -NDGA-) on platelet aggregation evoked by collagen or adenosinediphosphate (ADP) as well as platelet adhesiveness to collagen f platelet-rich-plasma (PRP) from aspiri...

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Publicado:	1983
Materias:	5,8,11,14 icosatetraynoic acid acetylsalicylic acid adenosine diphosphate alcohol arachidonic acid collagen dimethyl sulfoxide nordihydroguaiaretic acid adhesion blood and hemopoietic system cardiovascular system controlled study drug mechanism drug sensitivity human human cell patient therapy thrombocyte aggregation thrombosis 5,8,11,14-Eicosatetraynoic Acid Adenosine Diphosphate Arachidonic Acid Arachidonic Acids Aspirin Catechols Collagen Humans Lipoxygenase Inhibitors Nordihydroguaiaretic Acid Platelet Adhesiveness Platelet Aggregation
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v11_n1_p109_Gimeno http://hdl.handle.net/20.500.12110/paper_02621746_v11_n1_p109_Gimeno
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_02621746_v11_n1_p109_Gimeno
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spelling	paper:paper_02621746_v11_n1_p109_Gimeno2023-06-08T15:22:49Z Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients 5,8,11,14 icosatetraynoic acid acetylsalicylic acid adenosine diphosphate alcohol arachidonic acid collagen dimethyl sulfoxide nordihydroguaiaretic acid adhesion blood and hemopoietic system cardiovascular system controlled study drug mechanism drug sensitivity human human cell patient therapy thrombocyte aggregation thrombosis 5,8,11,14-Eicosatetraynoic Acid Adenosine Diphosphate Arachidonic Acid Arachidonic Acids Aspirin Catechols Collagen Humans Lipoxygenase Inhibitors Nordihydroguaiaretic Acid Platelet Adhesiveness Platelet Aggregation The influences of arachidonic acid (AA) and of inhibitors of lipoxygenases (eicosetetraynoic acid-ETYA- and nordihydrogusiaretic acid -NDGA-) on platelet aggregation evoked by collagen or adenosinediphosphate (ADP) as well as platelet adhesiveness to collagen f platelet-rich-plasma (PRP) from aspirin-treated patients were explored. ETYA or NDGA (10-8 and 10-7 M) clearly diminished the per cent aggregation evoked by collagen or ADP and delayed its onset. On the other hand AA (0.2 mM) enhanced the aggregation and shortened the leg phase evoked by collagen at 1.2 and 2.6 ug/ml, but not at 5.2 ug/ml. Platelet-collagen adhesion of PRP was significantly reduced by ETYA or NDGA (10-7 M) and augmented by AA (2 mM). The results strongly suggest that lipoxygenese products of arachidonate metabolism play an important role in promoting the mechanisms) underlying human platelet aggregation and adhesiveness. © 1983. 1983 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v11_n1_p109_Gimeno http://hdl.handle.net/20.500.12110/paper_02621746_v11_n1_p109_Gimeno
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	5,8,11,14 icosatetraynoic acid acetylsalicylic acid adenosine diphosphate alcohol arachidonic acid collagen dimethyl sulfoxide nordihydroguaiaretic acid adhesion blood and hemopoietic system cardiovascular system controlled study drug mechanism drug sensitivity human human cell patient therapy thrombocyte aggregation thrombosis 5,8,11,14-Eicosatetraynoic Acid Adenosine Diphosphate Arachidonic Acid Arachidonic Acids Aspirin Catechols Collagen Humans Lipoxygenase Inhibitors Nordihydroguaiaretic Acid Platelet Adhesiveness Platelet Aggregation
spellingShingle	5,8,11,14 icosatetraynoic acid acetylsalicylic acid adenosine diphosphate alcohol arachidonic acid collagen dimethyl sulfoxide nordihydroguaiaretic acid adhesion blood and hemopoietic system cardiovascular system controlled study drug mechanism drug sensitivity human human cell patient therapy thrombocyte aggregation thrombosis 5,8,11,14-Eicosatetraynoic Acid Adenosine Diphosphate Arachidonic Acid Arachidonic Acids Aspirin Catechols Collagen Humans Lipoxygenase Inhibitors Nordihydroguaiaretic Acid Platelet Adhesiveness Platelet Aggregation Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients
topic_facet	5,8,11,14 icosatetraynoic acid acetylsalicylic acid adenosine diphosphate alcohol arachidonic acid collagen dimethyl sulfoxide nordihydroguaiaretic acid adhesion blood and hemopoietic system cardiovascular system controlled study drug mechanism drug sensitivity human human cell patient therapy thrombocyte aggregation thrombosis 5,8,11,14-Eicosatetraynoic Acid Adenosine Diphosphate Arachidonic Acid Arachidonic Acids Aspirin Catechols Collagen Humans Lipoxygenase Inhibitors Nordihydroguaiaretic Acid Platelet Adhesiveness Platelet Aggregation
description	The influences of arachidonic acid (AA) and of inhibitors of lipoxygenases (eicosetetraynoic acid-ETYA- and nordihydrogusiaretic acid -NDGA-) on platelet aggregation evoked by collagen or adenosinediphosphate (ADP) as well as platelet adhesiveness to collagen f platelet-rich-plasma (PRP) from aspirin-treated patients were explored. ETYA or NDGA (10-8 and 10-7 M) clearly diminished the per cent aggregation evoked by collagen or ADP and delayed its onset. On the other hand AA (0.2 mM) enhanced the aggregation and shortened the leg phase evoked by collagen at 1.2 and 2.6 ug/ml, but not at 5.2 ug/ml. Platelet-collagen adhesion of PRP was significantly reduced by ETYA or NDGA (10-7 M) and augmented by AA (2 mM). The results strongly suggest that lipoxygenese products of arachidonate metabolism play an important role in promoting the mechanisms) underlying human platelet aggregation and adhesiveness. © 1983.
title	Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients
title_short	Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients
title_full	Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients
title_fullStr	Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients
title_full_unstemmed	Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients
title_sort	lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients
publishDate	1983
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v11_n1_p109_Gimeno http://hdl.handle.net/20.500.12110/paper_02621746_v11_n1_p109_Gimeno
_version_	1768546490409549824

Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients

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