Evaluation of the porphyrinogenic risk of antineoplastics

The use of antineoplastics is common in cancer therapy, and some of them have been associated with the development of porphyria in patients with cancer. However, knowledge of their effects on the haeme metabolic pathway is at present scarce and unclear. So, the present study evaluates the porphyrino...

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Autores principales:	Cochón, Adriana Cristina, San Martín de Viale, Leonor Carmen
Publicado:	1997
Materias:	δ-Aminolaevulinic acid synthase Antineoplastics Ferrochelatase Porphyria Porphyrins Protoporphyrinogen oxidase 5 aminolevulinate synthase alkylating agent altretamine antineoplastic agent azathioprine busulfan chlorambucil cyclophosphamide dacarbazine ferrochelatase fluorouracil melphalan porphyrin procarbazine protoporphyrinogen oxidase animal experiment animal tissue article cancer chemotherapy chick embryo controlled study drug mechanism embryo enzyme activity female intraperitoneal drug administration liver male mouse nonhuman porphyria priority journal species difference structure activity relation Alkylating Agents Altretamine Animals Antineoplastic Agents Azathioprine Busulfan Chick Embryo Cyclophosphamide Dacarbazine Dicarbethoxydihydrocollidine Female Flavoproteins Fluorouracil Liver Male Mice Mice, Inbred BALB C Mitochondrial Proteins Oxidoreductases Oxidoreductases Acting on CH-CH Group Donors Porphyrias Procarbazine Protoporphyrinogen Oxidase Structure-Activity Relationship Animalia
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0260437X_v17_n3_p171_Cochon http://hdl.handle.net/20.500.12110/paper_0260437X_v17_n3_p171_Cochon
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_0260437X_v17_n3_p171_Cochon
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spelling	paper:paper_0260437X_v17_n3_p171_Cochon2023-06-08T15:22:13Z Evaluation of the porphyrinogenic risk of antineoplastics Cochón, Adriana Cristina San Martín de Viale, Leonor Carmen δ-Aminolaevulinic acid synthase Antineoplastics Ferrochelatase Porphyria Porphyrins Protoporphyrinogen oxidase 5 aminolevulinate synthase alkylating agent altretamine antineoplastic agent azathioprine busulfan chlorambucil cyclophosphamide dacarbazine ferrochelatase fluorouracil melphalan porphyrin procarbazine protoporphyrinogen oxidase animal experiment animal tissue article cancer chemotherapy chick embryo controlled study drug mechanism embryo enzyme activity female intraperitoneal drug administration liver male mouse nonhuman porphyria priority journal species difference structure activity relation Alkylating Agents Altretamine Animals Antineoplastic Agents Azathioprine Busulfan Chick Embryo Cyclophosphamide Dacarbazine Dicarbethoxydihydrocollidine Female Ferrochelatase Flavoproteins Fluorouracil Liver Male Mice Mice, Inbred BALB C Mitochondrial Proteins Oxidoreductases Oxidoreductases Acting on CH-CH Group Donors Porphyrias Porphyrins Procarbazine Protoporphyrinogen Oxidase Structure-Activity Relationship Animalia The use of antineoplastics is common in cancer therapy, and some of them have been associated with the development of porphyria in patients with cancer. However, knowledge of their effects on the haeme metabolic pathway is at present scarce and unclear. So, the present study evaluates the porphyrinogenic ability of nine antineoplastics (both alkylating and non-alkylating). These were tested either alone or in conjunction with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (latent porphyria model) in chick embryos and in mice. The results obtained suggest that the use of cyclophosphamide, azathioprine, 5-fluorouracil, busulphan, procarbazine and hexamethylmelamine be avoided in the treatment of porphyric patients. On the other hand, dacarbazine, chlorambucil and melphalan are non-porphyrinogenic. We also provide evidence showing that neither the presence of the mustard group in the structure of the antineoplastic nor alterations in ferrochelatase or protoporphyrinogen oxidase activities are responsible for the porphyrinogenic ability of cyclophosphamide. Fil:Cochón, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:San Martín De Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1997 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0260437X_v17_n3_p171_Cochon http://hdl.handle.net/20.500.12110/paper_0260437X_v17_n3_p171_Cochon
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	δ-Aminolaevulinic acid synthase Antineoplastics Ferrochelatase Porphyria Porphyrins Protoporphyrinogen oxidase 5 aminolevulinate synthase alkylating agent altretamine antineoplastic agent azathioprine busulfan chlorambucil cyclophosphamide dacarbazine ferrochelatase fluorouracil melphalan porphyrin procarbazine protoporphyrinogen oxidase animal experiment animal tissue article cancer chemotherapy chick embryo controlled study drug mechanism embryo enzyme activity female intraperitoneal drug administration liver male mouse nonhuman porphyria priority journal species difference structure activity relation Alkylating Agents Altretamine Animals Antineoplastic Agents Azathioprine Busulfan Chick Embryo Cyclophosphamide Dacarbazine Dicarbethoxydihydrocollidine Female Ferrochelatase Flavoproteins Fluorouracil Liver Male Mice Mice, Inbred BALB C Mitochondrial Proteins Oxidoreductases Oxidoreductases Acting on CH-CH Group Donors Porphyrias Porphyrins Procarbazine Protoporphyrinogen Oxidase Structure-Activity Relationship Animalia
spellingShingle	δ-Aminolaevulinic acid synthase Antineoplastics Ferrochelatase Porphyria Porphyrins Protoporphyrinogen oxidase 5 aminolevulinate synthase alkylating agent altretamine antineoplastic agent azathioprine busulfan chlorambucil cyclophosphamide dacarbazine ferrochelatase fluorouracil melphalan porphyrin procarbazine protoporphyrinogen oxidase animal experiment animal tissue article cancer chemotherapy chick embryo controlled study drug mechanism embryo enzyme activity female intraperitoneal drug administration liver male mouse nonhuman porphyria priority journal species difference structure activity relation Alkylating Agents Altretamine Animals Antineoplastic Agents Azathioprine Busulfan Chick Embryo Cyclophosphamide Dacarbazine Dicarbethoxydihydrocollidine Female Ferrochelatase Flavoproteins Fluorouracil Liver Male Mice Mice, Inbred BALB C Mitochondrial Proteins Oxidoreductases Oxidoreductases Acting on CH-CH Group Donors Porphyrias Porphyrins Procarbazine Protoporphyrinogen Oxidase Structure-Activity Relationship Animalia Cochón, Adriana Cristina San Martín de Viale, Leonor Carmen Evaluation of the porphyrinogenic risk of antineoplastics
topic_facet	δ-Aminolaevulinic acid synthase Antineoplastics Ferrochelatase Porphyria Porphyrins Protoporphyrinogen oxidase 5 aminolevulinate synthase alkylating agent altretamine antineoplastic agent azathioprine busulfan chlorambucil cyclophosphamide dacarbazine ferrochelatase fluorouracil melphalan porphyrin procarbazine protoporphyrinogen oxidase animal experiment animal tissue article cancer chemotherapy chick embryo controlled study drug mechanism embryo enzyme activity female intraperitoneal drug administration liver male mouse nonhuman porphyria priority journal species difference structure activity relation Alkylating Agents Altretamine Animals Antineoplastic Agents Azathioprine Busulfan Chick Embryo Cyclophosphamide Dacarbazine Dicarbethoxydihydrocollidine Female Ferrochelatase Flavoproteins Fluorouracil Liver Male Mice Mice, Inbred BALB C Mitochondrial Proteins Oxidoreductases Oxidoreductases Acting on CH-CH Group Donors Porphyrias Porphyrins Procarbazine Protoporphyrinogen Oxidase Structure-Activity Relationship Animalia
description	The use of antineoplastics is common in cancer therapy, and some of them have been associated with the development of porphyria in patients with cancer. However, knowledge of their effects on the haeme metabolic pathway is at present scarce and unclear. So, the present study evaluates the porphyrinogenic ability of nine antineoplastics (both alkylating and non-alkylating). These were tested either alone or in conjunction with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (latent porphyria model) in chick embryos and in mice. The results obtained suggest that the use of cyclophosphamide, azathioprine, 5-fluorouracil, busulphan, procarbazine and hexamethylmelamine be avoided in the treatment of porphyric patients. On the other hand, dacarbazine, chlorambucil and melphalan are non-porphyrinogenic. We also provide evidence showing that neither the presence of the mustard group in the structure of the antineoplastic nor alterations in ferrochelatase or protoporphyrinogen oxidase activities are responsible for the porphyrinogenic ability of cyclophosphamide.
author	Cochón, Adriana Cristina San Martín de Viale, Leonor Carmen
author_facet	Cochón, Adriana Cristina San Martín de Viale, Leonor Carmen
author_sort	Cochón, Adriana Cristina
title	Evaluation of the porphyrinogenic risk of antineoplastics
title_short	Evaluation of the porphyrinogenic risk of antineoplastics
title_full	Evaluation of the porphyrinogenic risk of antineoplastics
title_fullStr	Evaluation of the porphyrinogenic risk of antineoplastics
title_full_unstemmed	Evaluation of the porphyrinogenic risk of antineoplastics
title_sort	evaluation of the porphyrinogenic risk of antineoplastics
publishDate	1997
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0260437X_v17_n3_p171_Cochon http://hdl.handle.net/20.500.12110/paper_0260437X_v17_n3_p171_Cochon
work_keys_str_mv	AT cochonadrianacristina evaluationoftheporphyrinogenicriskofantineoplastics AT sanmartindevialeleonorcarmen evaluationoftheporphyrinogenicriskofantineoplastics
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Evaluation of the porphyrinogenic risk of antineoplastics

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