Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure
Complexes of stoichiometries [M(oda)(4-pic)H 2 O]·xH 2 O [M = Cu(1), x = 2; Co (2), x = 4; Ni (3), x = 2; ] [Fe(oda)(4-pic)]·Cl (4) and {[Cu(2-pa) 2 ]·2H 2 O} n (5) (H 2 oda = oxydiacetic acid, 4-pic = 4-picoline and 2-paH = 2-picolinic acid) were prepared to explore their uses as possible models fo...
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2012
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02235234_v57_n_p102_Siddiqi http://hdl.handle.net/20.500.12110/paper_02235234_v57_n_p102_Siddiqi |
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paper:paper_02235234_v57_n_p102_Siddiqi2023-06-08T15:21:44Z Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure 2-Picolinic acid 4-Pcoline Antimicrobial activities Oxydiacetic acid Superoxide dismutase (SOD) activity Ternary complexes cobalt complex copper complex iron complex ligand metal complex nickel complex oxydiacetic acid picoline picolinic acid superoxide dismutase transition element unclassified drug antibacterial activity antifungal activity antimicrobial activity article Aspergillus fumigatus Bacillus subtilis Candida albicans carbon nuclear magnetic resonance chemical structure complex formation crystal structure cyclic potentiometry electron spin resonance enzyme activity Escherichia coli fast atom bombardment mass spectrometry infrared spectroscopy nonhuman Penicillium marneffei proton nuclear magnetic resonance Salmonella typhimurium Staphylococcus aureus stoichiometry structure analysis supramolecular chemistry ultraviolet spectroscopy Acetates Anti-Infective Agents Bacteria Coordination Complexes Crystallography, X-Ray Electrochemical Techniques Fungi Hydrogen Bonding Magnetic Resonance Spectroscopy Metals, Heavy Microbial Viability Molecular Structure Nitroblue Tetrazolium Picolines Picolinic Acids Spectrophotometry, Infrared Superoxide Dismutase Superoxides Complexes of stoichiometries [M(oda)(4-pic)H 2 O]·xH 2 O [M = Cu(1), x = 2; Co (2), x = 4; Ni (3), x = 2; ] [Fe(oda)(4-pic)]·Cl (4) and {[Cu(2-pa) 2 ]·2H 2 O} n (5) (H 2 oda = oxydiacetic acid, 4-pic = 4-picoline and 2-paH = 2-picolinic acid) were prepared to explore their uses as possible models for mono- and poly-nuclear metallo-pharmaceuticals. The chemical structures were elucidated by IR, FAB-Mass, 1 H, 13 C NMR, EPR and UV-visible (ligand field) spectral analyses. Electrochemical investigations are consistent with formation of stable quasi-reversible redox Co II/III and Cu II/III couples in the solution. Single crystal X-ray data of the complex (5) indicated a 1D coordination polymeric structure with extensive H-bonding to form supramolecular frameworks. The antimicrobial activities were examined against Escherichia coli (k-12), Bacillus subtilis (MTC-121), Staphylococcus aureus (IOASA-22), Salmonella typhimurium (MTCC-98), Candida albicans, Aspergillus fumigatus and Penicillium marneffei. The superoxide dismutase (SOD) activities of the Cu(II) complexes (1 and 5) were assessed employing nitrobluetetrazolium (NBT) assay. © 2012 Elsevier Masson SAS. All rights reserved. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02235234_v57_n_p102_Siddiqi http://hdl.handle.net/20.500.12110/paper_02235234_v57_n_p102_Siddiqi |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
2-Picolinic acid 4-Pcoline Antimicrobial activities Oxydiacetic acid Superoxide dismutase (SOD) activity Ternary complexes cobalt complex copper complex iron complex ligand metal complex nickel complex oxydiacetic acid picoline picolinic acid superoxide dismutase transition element unclassified drug antibacterial activity antifungal activity antimicrobial activity article Aspergillus fumigatus Bacillus subtilis Candida albicans carbon nuclear magnetic resonance chemical structure complex formation crystal structure cyclic potentiometry electron spin resonance enzyme activity Escherichia coli fast atom bombardment mass spectrometry infrared spectroscopy nonhuman Penicillium marneffei proton nuclear magnetic resonance Salmonella typhimurium Staphylococcus aureus stoichiometry structure analysis supramolecular chemistry ultraviolet spectroscopy Acetates Anti-Infective Agents Bacteria Coordination Complexes Crystallography, X-Ray Electrochemical Techniques Fungi Hydrogen Bonding Magnetic Resonance Spectroscopy Metals, Heavy Microbial Viability Molecular Structure Nitroblue Tetrazolium Picolines Picolinic Acids Spectrophotometry, Infrared Superoxide Dismutase Superoxides |
| spellingShingle |
2-Picolinic acid 4-Pcoline Antimicrobial activities Oxydiacetic acid Superoxide dismutase (SOD) activity Ternary complexes cobalt complex copper complex iron complex ligand metal complex nickel complex oxydiacetic acid picoline picolinic acid superoxide dismutase transition element unclassified drug antibacterial activity antifungal activity antimicrobial activity article Aspergillus fumigatus Bacillus subtilis Candida albicans carbon nuclear magnetic resonance chemical structure complex formation crystal structure cyclic potentiometry electron spin resonance enzyme activity Escherichia coli fast atom bombardment mass spectrometry infrared spectroscopy nonhuman Penicillium marneffei proton nuclear magnetic resonance Salmonella typhimurium Staphylococcus aureus stoichiometry structure analysis supramolecular chemistry ultraviolet spectroscopy Acetates Anti-Infective Agents Bacteria Coordination Complexes Crystallography, X-Ray Electrochemical Techniques Fungi Hydrogen Bonding Magnetic Resonance Spectroscopy Metals, Heavy Microbial Viability Molecular Structure Nitroblue Tetrazolium Picolines Picolinic Acids Spectrophotometry, Infrared Superoxide Dismutase Superoxides Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure |
| topic_facet |
2-Picolinic acid 4-Pcoline Antimicrobial activities Oxydiacetic acid Superoxide dismutase (SOD) activity Ternary complexes cobalt complex copper complex iron complex ligand metal complex nickel complex oxydiacetic acid picoline picolinic acid superoxide dismutase transition element unclassified drug antibacterial activity antifungal activity antimicrobial activity article Aspergillus fumigatus Bacillus subtilis Candida albicans carbon nuclear magnetic resonance chemical structure complex formation crystal structure cyclic potentiometry electron spin resonance enzyme activity Escherichia coli fast atom bombardment mass spectrometry infrared spectroscopy nonhuman Penicillium marneffei proton nuclear magnetic resonance Salmonella typhimurium Staphylococcus aureus stoichiometry structure analysis supramolecular chemistry ultraviolet spectroscopy Acetates Anti-Infective Agents Bacteria Coordination Complexes Crystallography, X-Ray Electrochemical Techniques Fungi Hydrogen Bonding Magnetic Resonance Spectroscopy Metals, Heavy Microbial Viability Molecular Structure Nitroblue Tetrazolium Picolines Picolinic Acids Spectrophotometry, Infrared Superoxide Dismutase Superoxides |
| description |
Complexes of stoichiometries [M(oda)(4-pic)H 2 O]·xH 2 O [M = Cu(1), x = 2; Co (2), x = 4; Ni (3), x = 2; ] [Fe(oda)(4-pic)]·Cl (4) and {[Cu(2-pa) 2 ]·2H 2 O} n (5) (H 2 oda = oxydiacetic acid, 4-pic = 4-picoline and 2-paH = 2-picolinic acid) were prepared to explore their uses as possible models for mono- and poly-nuclear metallo-pharmaceuticals. The chemical structures were elucidated by IR, FAB-Mass, 1 H, 13 C NMR, EPR and UV-visible (ligand field) spectral analyses. Electrochemical investigations are consistent with formation of stable quasi-reversible redox Co II/III and Cu II/III couples in the solution. Single crystal X-ray data of the complex (5) indicated a 1D coordination polymeric structure with extensive H-bonding to form supramolecular frameworks. The antimicrobial activities were examined against Escherichia coli (k-12), Bacillus subtilis (MTC-121), Staphylococcus aureus (IOASA-22), Salmonella typhimurium (MTCC-98), Candida albicans, Aspergillus fumigatus and Penicillium marneffei. The superoxide dismutase (SOD) activities of the Cu(II) complexes (1 and 5) were assessed employing nitrobluetetrazolium (NBT) assay. © 2012 Elsevier Masson SAS. All rights reserved. |
| title |
Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure |
| title_short |
Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure |
| title_full |
Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure |
| title_fullStr |
Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure |
| title_full_unstemmed |
Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure |
| title_sort |
superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: spectral characterization, cyclic voltammetric investigations and crystal structure |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02235234_v57_n_p102_Siddiqi http://hdl.handle.net/20.500.12110/paper_02235234_v57_n_p102_Siddiqi |
| _version_ |
1768542835739459584 |