Disseminated tuberculosis with cutaneous manifestations in AIDS patients. Presentation of 4 cases

BACKGROUND: Acute cutaneous miliary tuberculosis is a rare form of Mycobacterium tuberculosis infection which has been described in only 25 published cases in the last 15 years. The appearance of serious disseminated forms of tuberculosis is enhanced by the severe immunodeficiency which characterize...

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Publicado:	1998
Materias:	Cutaneous tuberculosis HIV Mycobacterium tuberculosis tuberculostatic agent acquired immune deficiency syndrome adult antibiotic sensitivity article case report fatality human male miliary tuberculosis multidrug resistance mycobacterium tuberculosis skin tuberculosis Acquired Immunodeficiency Syndrome Adult Humans Male Tuberculosis, Cutaneous Tuberculosis, Miliary
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0213005X_v16_n1_p31_Esquivel http://hdl.handle.net/20.500.12110/paper_0213005X_v16_n1_p31_Esquivel
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_0213005X_v16_n1_p31_Esquivel
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spelling	paper:paper_0213005X_v16_n1_p31_Esquivel2023-06-08T15:20:46Z Disseminated tuberculosis with cutaneous manifestations in AIDS patients. Presentation of 4 cases Cutaneous tuberculosis HIV Mycobacterium tuberculosis tuberculostatic agent acquired immune deficiency syndrome adult antibiotic sensitivity article case report fatality human male miliary tuberculosis multidrug resistance mycobacterium tuberculosis acquired immune deficiency syndrome miliary tuberculosis skin tuberculosis Acquired Immunodeficiency Syndrome Adult Humans Male Tuberculosis, Cutaneous Tuberculosis, Miliary BACKGROUND: Acute cutaneous miliary tuberculosis is a rare form of Mycobacterium tuberculosis infection which has been described in only 25 published cases in the last 15 years. The appearance of serious disseminated forms of tuberculosis is enhanced by the severe immunodeficiency which characterizes AIDS. METHODS: Four cases are described of disseminated tuberculosis with cutaneous localization clinically described as the acute miliary form. Patients had AIDS and CD4 lymphocyte levels of < 100 cells/mm3. Diagnosis was established in all cases by scraping of cutaneous lesions and direct examination with Ziehl-Neelsen coloration. RESULTS: The 4 patients presented signs and symptoms of disseminated tuberculosis with cutaneous manifestations, without a definite pattern and with localization predominantly on the thorax. Three had BAAR-positive sputum. Multiresistant strains of Mycobacterium tuberculosis were confirmed by antibiogram. One patient infected by a strain sensitive to first-line drugs responded favorably to conventional treatment for disseminated tuberculosis. In the remaining three with multiresistant strains, the evolution of the disease was rapid and unfavorable. CONCLUSIONS: Abrupt appearance of cutaneous lesions in a patient with disseminated tuberculosis and advanced HIV-disease should raise the suspicion of its etiology. Scraping and direct examination using Ziehl-Neelsen coloration is practical, economical and non-invasive diagnostic method. 1998 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0213005X_v16_n1_p31_Esquivel http://hdl.handle.net/20.500.12110/paper_0213005X_v16_n1_p31_Esquivel
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Cutaneous tuberculosis HIV Mycobacterium tuberculosis tuberculostatic agent acquired immune deficiency syndrome adult antibiotic sensitivity article case report fatality human male miliary tuberculosis multidrug resistance mycobacterium tuberculosis acquired immune deficiency syndrome miliary tuberculosis skin tuberculosis Acquired Immunodeficiency Syndrome Adult Humans Male Tuberculosis, Cutaneous Tuberculosis, Miliary
spellingShingle	Cutaneous tuberculosis HIV Mycobacterium tuberculosis tuberculostatic agent acquired immune deficiency syndrome adult antibiotic sensitivity article case report fatality human male miliary tuberculosis multidrug resistance mycobacterium tuberculosis acquired immune deficiency syndrome miliary tuberculosis skin tuberculosis Acquired Immunodeficiency Syndrome Adult Humans Male Tuberculosis, Cutaneous Tuberculosis, Miliary Disseminated tuberculosis with cutaneous manifestations in AIDS patients. Presentation of 4 cases
topic_facet	Cutaneous tuberculosis HIV Mycobacterium tuberculosis tuberculostatic agent acquired immune deficiency syndrome adult antibiotic sensitivity article case report fatality human male miliary tuberculosis multidrug resistance mycobacterium tuberculosis acquired immune deficiency syndrome miliary tuberculosis skin tuberculosis Acquired Immunodeficiency Syndrome Adult Humans Male Tuberculosis, Cutaneous Tuberculosis, Miliary
description	BACKGROUND: Acute cutaneous miliary tuberculosis is a rare form of Mycobacterium tuberculosis infection which has been described in only 25 published cases in the last 15 years. The appearance of serious disseminated forms of tuberculosis is enhanced by the severe immunodeficiency which characterizes AIDS. METHODS: Four cases are described of disseminated tuberculosis with cutaneous localization clinically described as the acute miliary form. Patients had AIDS and CD4 lymphocyte levels of < 100 cells/mm3. Diagnosis was established in all cases by scraping of cutaneous lesions and direct examination with Ziehl-Neelsen coloration. RESULTS: The 4 patients presented signs and symptoms of disseminated tuberculosis with cutaneous manifestations, without a definite pattern and with localization predominantly on the thorax. Three had BAAR-positive sputum. Multiresistant strains of Mycobacterium tuberculosis were confirmed by antibiogram. One patient infected by a strain sensitive to first-line drugs responded favorably to conventional treatment for disseminated tuberculosis. In the remaining three with multiresistant strains, the evolution of the disease was rapid and unfavorable. CONCLUSIONS: Abrupt appearance of cutaneous lesions in a patient with disseminated tuberculosis and advanced HIV-disease should raise the suspicion of its etiology. Scraping and direct examination using Ziehl-Neelsen coloration is practical, economical and non-invasive diagnostic method.
title	Disseminated tuberculosis with cutaneous manifestations in AIDS patients. Presentation of 4 cases
title_short	Disseminated tuberculosis with cutaneous manifestations in AIDS patients. Presentation of 4 cases
title_full	Disseminated tuberculosis with cutaneous manifestations in AIDS patients. Presentation of 4 cases
title_fullStr	Disseminated tuberculosis with cutaneous manifestations in AIDS patients. Presentation of 4 cases
title_full_unstemmed	Disseminated tuberculosis with cutaneous manifestations in AIDS patients. Presentation of 4 cases
title_sort	disseminated tuberculosis with cutaneous manifestations in aids patients. presentation of 4 cases
publishDate	1998
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0213005X_v16_n1_p31_Esquivel http://hdl.handle.net/20.500.12110/paper_0213005X_v16_n1_p31_Esquivel
_version_	1768544862283497472

Disseminated tuberculosis with cutaneous manifestations in AIDS patients. Presentation of 4 cases

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