Significance of complex analysis of electrical activity in temporal lobe epilepsy: Electrocorticography
Introduction. Locating and excising epileptogenic zones is the traditional treatment in pharmacoresistant temporal lobe epilepsy. Some patients, however, continue to sufer from attacks even after surgery. Therefore, new hypotheses must be formulated in order to account for the apparent shortcomings...
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2012
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paper:paper_02100010_v55_n4_p207_Palmigiano2023-06-08T15:20:42Z Significance of complex analysis of electrical activity in temporal lobe epilepsy: Electrocorticography Cluster Complex networks Foramen ovale electrodes Synchronization Temporal lobe epilepsy article clinical article cortical synchronization electric activity electrocorticography human intraoperative period limbic cortex limbic network nerve cell network postoperative period surgical risk temporal lobe epilepsy adult algorithm biological model electroencephalography female male middle aged nuclear magnetic resonance imaging pathophysiology single photon emission computer tomography statistics temporal lobe temporal lobe epilepsy diagnostic agent hexamethylpropylene amine oxime technetium tc 99m radiopharmaceutical agent Adult Algorithms Cortical Synchronization Electroencephalography Epilepsy, Temporal Lobe Female Humans Magnetic Resonance Imaging Male Middle Aged Models, Neurological Radiopharmaceuticals Technetium Tc 99m Exametazime Temporal Lobe Tomography, Emission-Computed, Single-Photon Young Adult Introduction. Locating and excising epileptogenic zones is the traditional treatment in pharmacoresistant temporal lobe epilepsy. Some patients, however, continue to sufer from attacks even after surgery. Therefore, new hypotheses must be formulated in order to account for the apparent shortcomings of correctly performed surgical procedures. Aims. An approach that is not traditional in the feld, namely complex networks, is used to attempt to show that modifying the properties of the limbic network can lead to the elimination of the attacks, regardless of the location of the epileptogenic zones. Patients and methods. The intraoperative electrocorticographic recordings of 20 patients with pharmacoresistant temporal lobe epilepsy were utilised in the study. An analysis of complex networks was used to study the local synchronisation activity in the lateral and mesial cortex of the temporal lobe and, essentially, the zones with the highest temporal stability were determined. Results. Those cortical zones with higher synchronic activity are associated with a greater temporal stability and when these zones are excised during surgery, the patient no longer sufers any disabling attacks. In contrast, when these zones are not excised, the patient continues to have attacks in the post-operative period. Conclusions. The fndings support the hypothesis of the existence of a limbic network, which the lateral and mesial cortices of the temporal lobe are part of, and whose capacity to establish an overall synchronisation is afected when certain zones are removed. © 2012 Revista de Neurología. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02100010_v55_n4_p207_Palmigiano http://hdl.handle.net/20.500.12110/paper_02100010_v55_n4_p207_Palmigiano |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cluster Complex networks Foramen ovale electrodes Synchronization Temporal lobe epilepsy article clinical article cortical synchronization electric activity electrocorticography human intraoperative period limbic cortex limbic network nerve cell network postoperative period surgical risk temporal lobe epilepsy adult algorithm biological model electroencephalography female male middle aged nuclear magnetic resonance imaging pathophysiology single photon emission computer tomography statistics temporal lobe temporal lobe epilepsy diagnostic agent hexamethylpropylene amine oxime technetium tc 99m radiopharmaceutical agent Adult Algorithms Cortical Synchronization Electroencephalography Epilepsy, Temporal Lobe Female Humans Magnetic Resonance Imaging Male Middle Aged Models, Neurological Radiopharmaceuticals Technetium Tc 99m Exametazime Temporal Lobe Tomography, Emission-Computed, Single-Photon Young Adult |
| spellingShingle |
Cluster Complex networks Foramen ovale electrodes Synchronization Temporal lobe epilepsy article clinical article cortical synchronization electric activity electrocorticography human intraoperative period limbic cortex limbic network nerve cell network postoperative period surgical risk temporal lobe epilepsy adult algorithm biological model electroencephalography female male middle aged nuclear magnetic resonance imaging pathophysiology single photon emission computer tomography statistics temporal lobe temporal lobe epilepsy diagnostic agent hexamethylpropylene amine oxime technetium tc 99m radiopharmaceutical agent Adult Algorithms Cortical Synchronization Electroencephalography Epilepsy, Temporal Lobe Female Humans Magnetic Resonance Imaging Male Middle Aged Models, Neurological Radiopharmaceuticals Technetium Tc 99m Exametazime Temporal Lobe Tomography, Emission-Computed, Single-Photon Young Adult Significance of complex analysis of electrical activity in temporal lobe epilepsy: Electrocorticography |
| topic_facet |
Cluster Complex networks Foramen ovale electrodes Synchronization Temporal lobe epilepsy article clinical article cortical synchronization electric activity electrocorticography human intraoperative period limbic cortex limbic network nerve cell network postoperative period surgical risk temporal lobe epilepsy adult algorithm biological model electroencephalography female male middle aged nuclear magnetic resonance imaging pathophysiology single photon emission computer tomography statistics temporal lobe temporal lobe epilepsy diagnostic agent hexamethylpropylene amine oxime technetium tc 99m radiopharmaceutical agent Adult Algorithms Cortical Synchronization Electroencephalography Epilepsy, Temporal Lobe Female Humans Magnetic Resonance Imaging Male Middle Aged Models, Neurological Radiopharmaceuticals Technetium Tc 99m Exametazime Temporal Lobe Tomography, Emission-Computed, Single-Photon Young Adult |
| description |
Introduction. Locating and excising epileptogenic zones is the traditional treatment in pharmacoresistant temporal lobe epilepsy. Some patients, however, continue to sufer from attacks even after surgery. Therefore, new hypotheses must be formulated in order to account for the apparent shortcomings of correctly performed surgical procedures. Aims. An approach that is not traditional in the feld, namely complex networks, is used to attempt to show that modifying the properties of the limbic network can lead to the elimination of the attacks, regardless of the location of the epileptogenic zones. Patients and methods. The intraoperative electrocorticographic recordings of 20 patients with pharmacoresistant temporal lobe epilepsy were utilised in the study. An analysis of complex networks was used to study the local synchronisation activity in the lateral and mesial cortex of the temporal lobe and, essentially, the zones with the highest temporal stability were determined. Results. Those cortical zones with higher synchronic activity are associated with a greater temporal stability and when these zones are excised during surgery, the patient no longer sufers any disabling attacks. In contrast, when these zones are not excised, the patient continues to have attacks in the post-operative period. Conclusions. The fndings support the hypothesis of the existence of a limbic network, which the lateral and mesial cortices of the temporal lobe are part of, and whose capacity to establish an overall synchronisation is afected when certain zones are removed. © 2012 Revista de Neurología. |
| title |
Significance of complex analysis of electrical activity in temporal lobe epilepsy: Electrocorticography |
| title_short |
Significance of complex analysis of electrical activity in temporal lobe epilepsy: Electrocorticography |
| title_full |
Significance of complex analysis of electrical activity in temporal lobe epilepsy: Electrocorticography |
| title_fullStr |
Significance of complex analysis of electrical activity in temporal lobe epilepsy: Electrocorticography |
| title_full_unstemmed |
Significance of complex analysis of electrical activity in temporal lobe epilepsy: Electrocorticography |
| title_sort |
significance of complex analysis of electrical activity in temporal lobe epilepsy: electrocorticography |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02100010_v55_n4_p207_Palmigiano http://hdl.handle.net/20.500.12110/paper_02100010_v55_n4_p207_Palmigiano |
| _version_ |
1768542936414289920 |