Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor

The establishment of a new human breast cancer cell line (IIB-BR-G) was successful after a previous growth of the cells isolated from a breast primary tumor in a female nude mouse. The IIB-BR-G cell line and the primary tumor do not express estrogen or progesterone receptors. Vimentin and keratin ex...

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Autores principales:	Bover, Laura del Carmen, Barrio, María Marcela
Publicado:	1991
Materias:	breast cancer cell line cytogenetics morphology article chromosome aberration female human human cell tumor cell line undifferentiated carcinoma Animal Breast Neoplasms Carcinoma, Intraductal, Noninfiltrating Cell Differentiation Cell Division Comparative Study Culture Media Female Human Immunohistochemistry Karyotyping Kinetics Mammary Neoplasms, Experimental Menopause Mice Mice, Nude Neoplasm Transplantation Receptors, Cell Surface Support, Non-U.S. Gov't Tumor Cells, Cultured
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01676806_v19_n1_p47_Bover http://hdl.handle.net/20.500.12110/paper_01676806_v19_n1_p47_Bover
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01676806_v19_n1_p47_Bover
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spelling	paper:paper_01676806_v19_n1_p47_Bover2023-06-08T15:16:42Z Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor Bover, Laura del Carmen Barrio, María Marcela breast cancer cell line cytogenetics morphology article breast cancer chromosome aberration female human human cell tumor cell line undifferentiated carcinoma Animal Breast Neoplasms Carcinoma, Intraductal, Noninfiltrating Cell Differentiation Cell Division Comparative Study Culture Media Female Human Immunohistochemistry Karyotyping Kinetics Mammary Neoplasms, Experimental Menopause Mice Mice, Nude Neoplasm Transplantation Receptors, Cell Surface Support, Non-U.S. Gov't Tumor Cells, Cultured The establishment of a new human breast cancer cell line (IIB-BR-G) was successful after a previous growth of the cells isolated from a breast primary tumor in a female nude mouse. The IIB-BR-G cell line and the primary tumor do not express estrogen or progesterone receptors. Vimentin and keratin expression were found in the cell line and in the nude mouse tumor. This cell line displays high morphological heterogeneity with atypical multinucleated megacells, and it is capable of anchorage-independent growth and tumor formation in nude mice. The cytogenetic analysis confirmed its human origin and revealed multiple marker chromosomes and extensive chromosomal alterations including rearrangements, gains, losses, isochromosomes, and double minutes (DMs). © 1991 Kluwer Academic Publishers. Fil:Bover, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Barrio, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1991 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01676806_v19_n1_p47_Bover http://hdl.handle.net/20.500.12110/paper_01676806_v19_n1_p47_Bover
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	breast cancer cell line cytogenetics morphology article breast cancer chromosome aberration female human human cell tumor cell line undifferentiated carcinoma Animal Breast Neoplasms Carcinoma, Intraductal, Noninfiltrating Cell Differentiation Cell Division Comparative Study Culture Media Female Human Immunohistochemistry Karyotyping Kinetics Mammary Neoplasms, Experimental Menopause Mice Mice, Nude Neoplasm Transplantation Receptors, Cell Surface Support, Non-U.S. Gov't Tumor Cells, Cultured
spellingShingle	breast cancer cell line cytogenetics morphology article breast cancer chromosome aberration female human human cell tumor cell line undifferentiated carcinoma Animal Breast Neoplasms Carcinoma, Intraductal, Noninfiltrating Cell Differentiation Cell Division Comparative Study Culture Media Female Human Immunohistochemistry Karyotyping Kinetics Mammary Neoplasms, Experimental Menopause Mice Mice, Nude Neoplasm Transplantation Receptors, Cell Surface Support, Non-U.S. Gov't Tumor Cells, Cultured Bover, Laura del Carmen Barrio, María Marcela Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor
topic_facet	breast cancer cell line cytogenetics morphology article breast cancer chromosome aberration female human human cell tumor cell line undifferentiated carcinoma Animal Breast Neoplasms Carcinoma, Intraductal, Noninfiltrating Cell Differentiation Cell Division Comparative Study Culture Media Female Human Immunohistochemistry Karyotyping Kinetics Mammary Neoplasms, Experimental Menopause Mice Mice, Nude Neoplasm Transplantation Receptors, Cell Surface Support, Non-U.S. Gov't Tumor Cells, Cultured
description	The establishment of a new human breast cancer cell line (IIB-BR-G) was successful after a previous growth of the cells isolated from a breast primary tumor in a female nude mouse. The IIB-BR-G cell line and the primary tumor do not express estrogen or progesterone receptors. Vimentin and keratin expression were found in the cell line and in the nude mouse tumor. This cell line displays high morphological heterogeneity with atypical multinucleated megacells, and it is capable of anchorage-independent growth and tumor formation in nude mice. The cytogenetic analysis confirmed its human origin and revealed multiple marker chromosomes and extensive chromosomal alterations including rearrangements, gains, losses, isochromosomes, and double minutes (DMs). © 1991 Kluwer Academic Publishers.
author	Bover, Laura del Carmen Barrio, María Marcela
author_facet	Bover, Laura del Carmen Barrio, María Marcela
author_sort	Bover, Laura del Carmen
title	Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor
title_short	Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor
title_full	Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor
title_fullStr	Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor
title_full_unstemmed	Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor
title_sort	description of a new human breast cancer cell line, iib-br-g, established from a primary undifferentiated tumor
publishDate	1991
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01676806_v19_n1_p47_Bover http://hdl.handle.net/20.500.12110/paper_01676806_v19_n1_p47_Bover
work_keys_str_mv	AT boverlauradelcarmen descriptionofanewhumanbreastcancercelllineiibbrgestablishedfromaprimaryundifferentiatedtumor AT barriomariamarcela descriptionofanewhumanbreastcancercelllineiibbrgestablishedfromaprimaryundifferentiatedtumor
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Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor

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