The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor
Erythropoietin (Epo) promotes the development of erythroid progenitors by triggering intracellular signals through the binding to its specific receptor (EpoR). Previous results related to the action of aluminum (Al) on erythropoiesis let us suggest that the metal affects Epo interaction with its tar...
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2005
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674889_v1743_n1-2_p29_Vittori http://hdl.handle.net/20.500.12110/paper_01674889_v1743_n1-2_p29_Vittori |
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paper:paper_01674889_v1743_n1-2_p29_Vittori2023-06-08T15:16:27Z The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor Aluminum Apoptosis Erythropoietin Erythropoietin receptor K562 cell UT-7 cell line aluminum erythropoietin erythropoietin receptor apoptosis article cell activation cell growth cell line cell proliferation cell survival controlled study human human cell priority journal protein expression signal transduction Erythropoietin (Epo) promotes the development of erythroid progenitors by triggering intracellular signals through the binding to its specific receptor (EpoR). Previous results related to the action of aluminum (Al) on erythropoiesis let us suggest that the metal affects Epo interaction with its target cells. In order to investigate this effect on cell activation by the Epo-EpoR complex, two human cell lines with different dependence on Epo were subjected to Al exposure. In the Epo-independent K562 cells, Al inhibited Epo antiapoptotic action and triggered a simultaneous decrease in protein and mRNA EpoR levels. On the other hand, proliferation of the strongly Epo-dependent UT-7 cells was enhanced by long-term Al treatment, in agreement with the upregulation of EpoR expression during Epo starvation. Results provide some clues to the way by which Epo supports cell survival and growth, and demonstrate that not all the intracellular factors needed to guarantee the different signaling pathways of Epo-cell activation are available or activated in cells expressing EpoR. This study then suggests that at least one of the mechanisms by which Al interfere with erythropoiesis might involve EpoR modulation. © 2004 Elsevier B.V. All rights reserved. 2005 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674889_v1743_n1-2_p29_Vittori http://hdl.handle.net/20.500.12110/paper_01674889_v1743_n1-2_p29_Vittori |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Aluminum Apoptosis Erythropoietin Erythropoietin receptor K562 cell UT-7 cell line aluminum erythropoietin erythropoietin receptor apoptosis article cell activation cell growth cell line cell proliferation cell survival controlled study human human cell priority journal protein expression signal transduction |
| spellingShingle |
Aluminum Apoptosis Erythropoietin Erythropoietin receptor K562 cell UT-7 cell line aluminum erythropoietin erythropoietin receptor apoptosis article cell activation cell growth cell line cell proliferation cell survival controlled study human human cell priority journal protein expression signal transduction The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor |
| topic_facet |
Aluminum Apoptosis Erythropoietin Erythropoietin receptor K562 cell UT-7 cell line aluminum erythropoietin erythropoietin receptor apoptosis article cell activation cell growth cell line cell proliferation cell survival controlled study human human cell priority journal protein expression signal transduction |
| description |
Erythropoietin (Epo) promotes the development of erythroid progenitors by triggering intracellular signals through the binding to its specific receptor (EpoR). Previous results related to the action of aluminum (Al) on erythropoiesis let us suggest that the metal affects Epo interaction with its target cells. In order to investigate this effect on cell activation by the Epo-EpoR complex, two human cell lines with different dependence on Epo were subjected to Al exposure. In the Epo-independent K562 cells, Al inhibited Epo antiapoptotic action and triggered a simultaneous decrease in protein and mRNA EpoR levels. On the other hand, proliferation of the strongly Epo-dependent UT-7 cells was enhanced by long-term Al treatment, in agreement with the upregulation of EpoR expression during Epo starvation. Results provide some clues to the way by which Epo supports cell survival and growth, and demonstrate that not all the intracellular factors needed to guarantee the different signaling pathways of Epo-cell activation are available or activated in cells expressing EpoR. This study then suggests that at least one of the mechanisms by which Al interfere with erythropoiesis might involve EpoR modulation. © 2004 Elsevier B.V. All rights reserved. |
| title |
The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor |
| title_short |
The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor |
| title_full |
The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor |
| title_fullStr |
The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor |
| title_full_unstemmed |
The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor |
| title_sort |
distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor |
| publishDate |
2005 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674889_v1743_n1-2_p29_Vittori http://hdl.handle.net/20.500.12110/paper_01674889_v1743_n1-2_p29_Vittori |
| _version_ |
1768541701831393280 |