Cloning and sequence analysis of the TcP2β cDNA variants of Trypanosoma cruzi
P2β acidic ribosomal protein is a relevant antigen in Chagas' disease. cDNA cloning demonstrated that Trypanosoma cruzi expresses at least six types of TcP2β transcripts that differed by point nucleotides substitutions. The distribution and type of mutations seemed to follow the typical structu...
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1995
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674781_v1264_n1_p15_Schijman http://hdl.handle.net/20.500.12110/paper_01674781_v1264_n1_p15_Schijman |
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paper:paper_01674781_v1264_n1_p15_Schijman2023-06-08T15:16:24Z Cloning and sequence analysis of the TcP2β cDNA variants of Trypanosoma cruzi Acidic ribosomal protein Chagas' disease Multigene family Phosphorylation site gene transcript ribosome protein unclassified drug amino acid sequence article chagas disease molecular cloning multigene family nonhuman nucleotide sequence phosphorylation priority journal trypanosoma cruzi Amino Acid Sequence Animal Base Sequence Cloning, Molecular DNA, Complementary Molecular Sequence Data Mutation Ribosomal Proteins Sequence Alignment Support, Non-U.S. Gov't Trypanosoma cruzi Eukaryota Trypanosoma Trypanosoma cruzi P2β acidic ribosomal protein is a relevant antigen in Chagas' disease. cDNA cloning demonstrated that Trypanosoma cruzi expresses at least six types of TcP2β transcripts that differed by point nucleotides substitutions. The distribution and type of mutations seemed to follow the typical structural organization of eukaryotic acidic ribosomal proteins. Most of the synonymous changes clustered in the amino-terminus, suggesting that conservation of this domain was crucial for an equivalent functional ability of each TcP2β variant to bind to the ribosome. Interestingly, most amino acid changes in the central-globular and hinge domains caused polymorphism in putative phosphorylatable sites. © 1995. 1995 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674781_v1264_n1_p15_Schijman http://hdl.handle.net/20.500.12110/paper_01674781_v1264_n1_p15_Schijman |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Acidic ribosomal protein Chagas' disease Multigene family Phosphorylation site gene transcript ribosome protein unclassified drug amino acid sequence article chagas disease molecular cloning multigene family nonhuman nucleotide sequence phosphorylation priority journal trypanosoma cruzi Amino Acid Sequence Animal Base Sequence Cloning, Molecular DNA, Complementary Molecular Sequence Data Mutation Ribosomal Proteins Sequence Alignment Support, Non-U.S. Gov't Trypanosoma cruzi Eukaryota Trypanosoma Trypanosoma cruzi |
spellingShingle |
Acidic ribosomal protein Chagas' disease Multigene family Phosphorylation site gene transcript ribosome protein unclassified drug amino acid sequence article chagas disease molecular cloning multigene family nonhuman nucleotide sequence phosphorylation priority journal trypanosoma cruzi Amino Acid Sequence Animal Base Sequence Cloning, Molecular DNA, Complementary Molecular Sequence Data Mutation Ribosomal Proteins Sequence Alignment Support, Non-U.S. Gov't Trypanosoma cruzi Eukaryota Trypanosoma Trypanosoma cruzi Cloning and sequence analysis of the TcP2β cDNA variants of Trypanosoma cruzi |
topic_facet |
Acidic ribosomal protein Chagas' disease Multigene family Phosphorylation site gene transcript ribosome protein unclassified drug amino acid sequence article chagas disease molecular cloning multigene family nonhuman nucleotide sequence phosphorylation priority journal trypanosoma cruzi Amino Acid Sequence Animal Base Sequence Cloning, Molecular DNA, Complementary Molecular Sequence Data Mutation Ribosomal Proteins Sequence Alignment Support, Non-U.S. Gov't Trypanosoma cruzi Eukaryota Trypanosoma Trypanosoma cruzi |
description |
P2β acidic ribosomal protein is a relevant antigen in Chagas' disease. cDNA cloning demonstrated that Trypanosoma cruzi expresses at least six types of TcP2β transcripts that differed by point nucleotides substitutions. The distribution and type of mutations seemed to follow the typical structural organization of eukaryotic acidic ribosomal proteins. Most of the synonymous changes clustered in the amino-terminus, suggesting that conservation of this domain was crucial for an equivalent functional ability of each TcP2β variant to bind to the ribosome. Interestingly, most amino acid changes in the central-globular and hinge domains caused polymorphism in putative phosphorylatable sites. © 1995. |
title |
Cloning and sequence analysis of the TcP2β cDNA variants of Trypanosoma cruzi |
title_short |
Cloning and sequence analysis of the TcP2β cDNA variants of Trypanosoma cruzi |
title_full |
Cloning and sequence analysis of the TcP2β cDNA variants of Trypanosoma cruzi |
title_fullStr |
Cloning and sequence analysis of the TcP2β cDNA variants of Trypanosoma cruzi |
title_full_unstemmed |
Cloning and sequence analysis of the TcP2β cDNA variants of Trypanosoma cruzi |
title_sort |
cloning and sequence analysis of the tcp2β cdna variants of trypanosoma cruzi |
publishDate |
1995 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674781_v1264_n1_p15_Schijman http://hdl.handle.net/20.500.12110/paper_01674781_v1264_n1_p15_Schijman |
_version_ |
1768544590933000192 |