Host Epac1 is required for cAMP-mediated invasion by Trypanosoma cruzi

Mechanistic details of the modulation by cAMP of Trypanosoma cruzi host cell invasion remain ill-defined. Here we report that activation of host's Epac1 stimulated invasion, whereas specific pharmacological inhibition or maneuvers that alter Epac1 subcellular localization significantly reduced...

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Autores principales:	Musikant, Alejandro Daniel, Buscaglia, Carlos Andrés, Altschuler, Daniel Leonardo, Edreira, Martín M.
Publicado:	2017
Materias:	cAMP Epac Invasion PKA Trypanosoma cruzi cyclic AMP cyclic AMP dependent protein kinase Epac1 protein protozoal protein unclassified drug Epac-1 protein, rat guanine nucleotide exchange factor Article cellular distribution host cell nonhuman priority journal protein localization protein synthesis signal transduction animal cell culture host parasite interaction metabolism pathogenicity physiology protein transport rat Animals Cells, Cultured Cyclic AMP Cyclic AMP-Dependent Protein Kinases Guanine Nucleotide Exchange Factors Host-Parasite Interactions Protein Transport Rats Signal Transduction
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01666851_v211_n_p67_Musikant http://hdl.handle.net/20.500.12110/paper_01666851_v211_n_p67_Musikant
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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