TcrPDEA1, a cAMP-specific phosphodiesterase with atypical pharmacological properties from Trypanosoma cruzi

Cyclic nucleotide phosphodiesterases (PDEs) catalyze the degradation of cAMP and cGMP, and regulate a variety of cellular processes by controlling the levels of these second messengers. We have previously described the presence of both a calcium-stimulated adenylyl cyclase and two membrane-bound cAM...

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Guardado en:
Detalles Bibliográficos
Publicado: 2007
Materias:
cAMP signaling
Chagas' disease
Kinetoplastids
Phosphodiesterase
calcium
calmodulin
cyclic AMP
cyclic AMP phosphodiesterase
cyclic AMP phosphodiesterase A1
isobutylmethylxanthine
papaverine
phosphodiesterase inhibitor
theophylline
unclassified drug
amino acid sequence
article
controlled study
enzyme activation
enzyme activity
enzyme kinetics
enzyme stability
enzyme substrate
fungal strain
gene frequency
genetic code
kinetoplast
mutant
nonhuman
nucleotide sequence
orthology
priority journal
protein family
protein function
signal transduction
Trypanosoma brucei
Trypanosoma cruzi
1-Methyl-3-isobutylxanthine
3',5'-Cyclic-Nucleotide Phosphodiesterase
5'-Guanylic Acid
Amino Acid Sequence
Animals
Calcium
Calmodulin
Coenzymes
DNA, Protozoan
Enzyme Activators
Enzyme Stability
Gene Dosage
Genetic Complementation Test
Magnesium
Molecular Sequence Data
Papaverine
Phosphodiesterase Inhibitors
Saccharomyces cerevisiae
Sequence Analysis, DNA
Substrate Specificity
Theophylline
Kinetoplastida
Trypanosomatidae
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01666851_v152_n1_p72_Alonso
http://hdl.handle.net/20.500.12110/paper_01666851_v152_n1_p72_Alonso
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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