Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors
The perinatal development of the nervous system is influenced by different external and internal stimuli. Previous data show that maternal care and perinatal inflammation can induce long-term changes in anxiety- and depression-related behavior. Our hypothesis is that both maternal care and perinatal...
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2010
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01664328_v213_n1_p56_Lucchina http://hdl.handle.net/20.500.12110/paper_01664328_v213_n1_p56_Lucchina |
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paper:paper_01664328_v213_n1_p56_Lucchina2023-06-08T15:15:44Z Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors Lucchina, Luciana Depino, Amaicha Mara Anxiety behavior Depression behavior F1 hybrids Maternal care Postnatal inflammation Principal component analysis Programming of adult behavior bacterium lipopolysaccharide corticosterone adulthood animal experiment animal model anxiety article attention controlled study coping behavior depression desensitization developmental stage female inflammation maternal behavior maternal care mother child relation mouse newborn nonhuman pedigree perinatal period priority journal validation process Aging Animals Animals, Newborn Anxiety Corticosterone Depression Female Inflammation Lipopolysaccharides Male Maternal Behavior Mice Mice, Inbred BALB C Mice, Inbred C57BL Neuropsychological Tests Random Allocation Sex Factors The perinatal development of the nervous system is influenced by different external and internal stimuli. Previous data show that maternal care and perinatal inflammation can induce long-term changes in anxiety- and depression-related behavior. Our hypothesis is that both maternal care and perinatal inflammation act through interacting biological pathways to program adult behavior. To evaluate this interaction, we combined a protocol of maternal care variation in mice (C57BL/6J × BALB/c reciprocal F1 offspring) with the administration of bacterial wall lipopolysaccharide (LPS) at a previously reported sensitive development age (postnatal day 3, P3). The analysis of maternal behavior revealed that pups from C57BL/6J dams received more maternal attention than those taken care by BALB/c dams. Pups receiving LPS at P3 showed an acute corticosterone response, and a dose-dependent desensitization of this hormonal response when challenged with LPS at adulthood. We analyzed adult behavior on 6 highly validated tests and found an interaction between maternal care and early postnatal LPS on 7 anxiety-related behaviors in 4 different tests. In particular, early postnatal LPS treatment resulted in higher anxiety-related behavior when administered to females receiving more maternal care (C57 pedigree), but reduced depression-related behavior in males of the same pedigree. These results suggest that specific coping strategies are sensitive to maternal care and/or postnatal inflammation programming of adult anxiety- and depression-related behaviors, suggesting that both divergent and convergent mechanisms participate in this programming. © 2010 Elsevier B.V. Fil:Lucchina, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Depino, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01664328_v213_n1_p56_Lucchina http://hdl.handle.net/20.500.12110/paper_01664328_v213_n1_p56_Lucchina |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Anxiety behavior Depression behavior F1 hybrids Maternal care Postnatal inflammation Principal component analysis Programming of adult behavior bacterium lipopolysaccharide corticosterone adulthood animal experiment animal model anxiety article attention controlled study coping behavior depression desensitization developmental stage female inflammation maternal behavior maternal care mother child relation mouse newborn nonhuman pedigree perinatal period priority journal validation process Aging Animals Animals, Newborn Anxiety Corticosterone Depression Female Inflammation Lipopolysaccharides Male Maternal Behavior Mice Mice, Inbred BALB C Mice, Inbred C57BL Neuropsychological Tests Random Allocation Sex Factors |
| spellingShingle |
Anxiety behavior Depression behavior F1 hybrids Maternal care Postnatal inflammation Principal component analysis Programming of adult behavior bacterium lipopolysaccharide corticosterone adulthood animal experiment animal model anxiety article attention controlled study coping behavior depression desensitization developmental stage female inflammation maternal behavior maternal care mother child relation mouse newborn nonhuman pedigree perinatal period priority journal validation process Aging Animals Animals, Newborn Anxiety Corticosterone Depression Female Inflammation Lipopolysaccharides Male Maternal Behavior Mice Mice, Inbred BALB C Mice, Inbred C57BL Neuropsychological Tests Random Allocation Sex Factors Lucchina, Luciana Depino, Amaicha Mara Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors |
| topic_facet |
Anxiety behavior Depression behavior F1 hybrids Maternal care Postnatal inflammation Principal component analysis Programming of adult behavior bacterium lipopolysaccharide corticosterone adulthood animal experiment animal model anxiety article attention controlled study coping behavior depression desensitization developmental stage female inflammation maternal behavior maternal care mother child relation mouse newborn nonhuman pedigree perinatal period priority journal validation process Aging Animals Animals, Newborn Anxiety Corticosterone Depression Female Inflammation Lipopolysaccharides Male Maternal Behavior Mice Mice, Inbred BALB C Mice, Inbred C57BL Neuropsychological Tests Random Allocation Sex Factors |
| description |
The perinatal development of the nervous system is influenced by different external and internal stimuli. Previous data show that maternal care and perinatal inflammation can induce long-term changes in anxiety- and depression-related behavior. Our hypothesis is that both maternal care and perinatal inflammation act through interacting biological pathways to program adult behavior. To evaluate this interaction, we combined a protocol of maternal care variation in mice (C57BL/6J × BALB/c reciprocal F1 offspring) with the administration of bacterial wall lipopolysaccharide (LPS) at a previously reported sensitive development age (postnatal day 3, P3). The analysis of maternal behavior revealed that pups from C57BL/6J dams received more maternal attention than those taken care by BALB/c dams. Pups receiving LPS at P3 showed an acute corticosterone response, and a dose-dependent desensitization of this hormonal response when challenged with LPS at adulthood. We analyzed adult behavior on 6 highly validated tests and found an interaction between maternal care and early postnatal LPS on 7 anxiety-related behaviors in 4 different tests. In particular, early postnatal LPS treatment resulted in higher anxiety-related behavior when administered to females receiving more maternal care (C57 pedigree), but reduced depression-related behavior in males of the same pedigree. These results suggest that specific coping strategies are sensitive to maternal care and/or postnatal inflammation programming of adult anxiety- and depression-related behaviors, suggesting that both divergent and convergent mechanisms participate in this programming. © 2010 Elsevier B.V. |
| author |
Lucchina, Luciana Depino, Amaicha Mara |
| author_facet |
Lucchina, Luciana Depino, Amaicha Mara |
| author_sort |
Lucchina, Luciana |
| title |
Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors |
| title_short |
Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors |
| title_full |
Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors |
| title_fullStr |
Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors |
| title_full_unstemmed |
Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors |
| title_sort |
evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors |
| publishDate |
2010 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01664328_v213_n1_p56_Lucchina http://hdl.handle.net/20.500.12110/paper_01664328_v213_n1_p56_Lucchina |
| work_keys_str_mv |
AT lucchinaluciana evaluatingtheinteractionbetweenearlypostnatalinflammationandmaternalcareintheprogrammingofadultanxietyanddepressionrelatedbehaviors AT depinoamaichamara evaluatingtheinteractionbetweenearlypostnatalinflammationandmaternalcareintheprogrammingofadultanxietyanddepressionrelatedbehaviors |
| _version_ |
1768543988034306048 |