Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1

The conventional therapy for the management of Herpes Simplex Virus Type 1 (HSV-1) infections mainly comprises acyclovir (ACV) and other nucleoside analogues. A common outcome of this treatment is the emergence of resistant viral strains, principally when immunosuppressed patients are involved. Thus...

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Autores principales:	Alche, Laura Edith, Ramirez, Javier Alberto, Barquero, Andrea Alejandra
Publicado:	2015
Materias:	Acyclovir resistant Antiviral Herpes simplex type I Non-natural side chains Pregnenolone analogs aciclovir glucocorticoid pregnenolone derivative antivirus agent pregnenolone animal cell antiviral activity antiviral resistance Article controlled study cytotoxicity drug synthesis Herpes simplex virus 1 nonhuman priority journal Vero cell line virus isolation virus strain analogs and derivatives animal Chlorocebus aethiops drug development drug effects growth, development and aging herpes simplex microbial sensitivity test synthesis Human herpesvirus 1 Acyclovir Animals Antiviral Agents Cercopithecus aethiops Drug Discovery Drug Resistance, Viral Herpes Simplex Herpesvirus 1, Human Microbial Sensitivity Tests Pregnenolone Vero Cells
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01663542_v122_n_p55_Davola http://hdl.handle.net/20.500.12110/paper_01663542_v122_n_p55_Davola
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01663542_v122_n_p55_Davola
record_format	dspace
spelling	paper:paper_01663542_v122_n_p55_Davola2023-06-08T15:15:38Z Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1 Alche, Laura Edith Ramirez, Javier Alberto Barquero, Andrea Alejandra Acyclovir resistant Antiviral Herpes simplex type I Non-natural side chains Pregnenolone analogs aciclovir glucocorticoid pregnenolone derivative aciclovir antivirus agent pregnenolone animal cell antiviral activity antiviral resistance Article controlled study cytotoxicity drug synthesis Herpes simplex virus 1 nonhuman priority journal Vero cell line virus isolation virus strain analogs and derivatives animal Chlorocebus aethiops drug development drug effects growth, development and aging herpes simplex Herpes simplex virus 1 microbial sensitivity test synthesis Human herpesvirus 1 Acyclovir Animals Antiviral Agents Cercopithecus aethiops Drug Discovery Drug Resistance, Viral Herpes Simplex Herpesvirus 1, Human Microbial Sensitivity Tests Pregnenolone Vero Cells The conventional therapy for the management of Herpes Simplex Virus Type 1 (HSV-1) infections mainly comprises acyclovir (ACV) and other nucleoside analogues. A common outcome of this treatment is the emergence of resistant viral strains, principally when immunosuppressed patients are involved. Thus, the development of new antiherpetic compounds remains as a central challenge. In this work we describe the synthesis and the in vitro antiherpetic activity of a new family of steroidal compounds derived from the endogenous hormone pregnenolone. Some of these derivatives showed a remarkable inhibitory effect on HSV-1 spread both on wild type and ACV-resistant strains. The results also show that these compounds seem to interfere with the late steps of the viral cycle. © 2015 Elsevier B.V. Fil:Alché, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ramírez, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Barquero, A.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01663542_v122_n_p55_Davola http://hdl.handle.net/20.500.12110/paper_01663542_v122_n_p55_Davola
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Acyclovir resistant Antiviral Herpes simplex type I Non-natural side chains Pregnenolone analogs aciclovir glucocorticoid pregnenolone derivative aciclovir antivirus agent pregnenolone animal cell antiviral activity antiviral resistance Article controlled study cytotoxicity drug synthesis Herpes simplex virus 1 nonhuman priority journal Vero cell line virus isolation virus strain analogs and derivatives animal Chlorocebus aethiops drug development drug effects growth, development and aging herpes simplex Herpes simplex virus 1 microbial sensitivity test synthesis Human herpesvirus 1 Acyclovir Animals Antiviral Agents Cercopithecus aethiops Drug Discovery Drug Resistance, Viral Herpes Simplex Herpesvirus 1, Human Microbial Sensitivity Tests Pregnenolone Vero Cells
spellingShingle	Acyclovir resistant Antiviral Herpes simplex type I Non-natural side chains Pregnenolone analogs aciclovir glucocorticoid pregnenolone derivative aciclovir antivirus agent pregnenolone animal cell antiviral activity antiviral resistance Article controlled study cytotoxicity drug synthesis Herpes simplex virus 1 nonhuman priority journal Vero cell line virus isolation virus strain analogs and derivatives animal Chlorocebus aethiops drug development drug effects growth, development and aging herpes simplex Herpes simplex virus 1 microbial sensitivity test synthesis Human herpesvirus 1 Acyclovir Animals Antiviral Agents Cercopithecus aethiops Drug Discovery Drug Resistance, Viral Herpes Simplex Herpesvirus 1, Human Microbial Sensitivity Tests Pregnenolone Vero Cells Alche, Laura Edith Ramirez, Javier Alberto Barquero, Andrea Alejandra Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1
topic_facet	Acyclovir resistant Antiviral Herpes simplex type I Non-natural side chains Pregnenolone analogs aciclovir glucocorticoid pregnenolone derivative aciclovir antivirus agent pregnenolone animal cell antiviral activity antiviral resistance Article controlled study cytotoxicity drug synthesis Herpes simplex virus 1 nonhuman priority journal Vero cell line virus isolation virus strain analogs and derivatives animal Chlorocebus aethiops drug development drug effects growth, development and aging herpes simplex Herpes simplex virus 1 microbial sensitivity test synthesis Human herpesvirus 1 Acyclovir Animals Antiviral Agents Cercopithecus aethiops Drug Discovery Drug Resistance, Viral Herpes Simplex Herpesvirus 1, Human Microbial Sensitivity Tests Pregnenolone Vero Cells
description	The conventional therapy for the management of Herpes Simplex Virus Type 1 (HSV-1) infections mainly comprises acyclovir (ACV) and other nucleoside analogues. A common outcome of this treatment is the emergence of resistant viral strains, principally when immunosuppressed patients are involved. Thus, the development of new antiherpetic compounds remains as a central challenge. In this work we describe the synthesis and the in vitro antiherpetic activity of a new family of steroidal compounds derived from the endogenous hormone pregnenolone. Some of these derivatives showed a remarkable inhibitory effect on HSV-1 spread both on wild type and ACV-resistant strains. The results also show that these compounds seem to interfere with the late steps of the viral cycle. © 2015 Elsevier B.V.
author	Alche, Laura Edith Ramirez, Javier Alberto Barquero, Andrea Alejandra
author_facet	Alche, Laura Edith Ramirez, Javier Alberto Barquero, Andrea Alejandra
author_sort	Alche, Laura Edith
title	Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1
title_short	Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1
title_full	Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1
title_fullStr	Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1
title_full_unstemmed	Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1
title_sort	synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of herpes simplex virus type 1
publishDate	2015
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01663542_v122_n_p55_Davola http://hdl.handle.net/20.500.12110/paper_01663542_v122_n_p55_Davola
work_keys_str_mv	AT alchelauraedith syntheticpregnenolonederivativesasantiviralagentsagainstacyclovirresistantisolatesofherpessimplexvirustype1 AT ramirezjavieralberto syntheticpregnenolonederivativesasantiviralagentsagainstacyclovirresistantisolatesofherpessimplexvirustype1 AT barqueroandreaalejandra syntheticpregnenolonederivativesasantiviralagentsagainstacyclovirresistantisolatesofherpessimplexvirustype1
_version_	1768546624853770240

Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1

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