CRF signaling: molecular specificity for drug targeting in the CNS
Corticotrophin-releasing factor (CRF) is the key mediator of the central nervous system response needed to adapt to stress. If adaptation fails, hypersecretion of CRF continues and produces, via CRF type 1 receptors, symptoms pertaining to cognition, appetite, sleep and anxiety, implicating CRF as a...
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2006
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01656147_v27_n10_p531_Arzt http://hdl.handle.net/20.500.12110/paper_01656147_v27_n10_p531_Arzt |
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paper:paper_01656147_v27_n10_p531_Arzt2023-06-08T15:15:02Z CRF signaling: molecular specificity for drug targeting in the CNS calcium ion corticotropin releasing factor corticotropin releasing factor receptor 1 cyclic AMP dependent protein kinase immunoglobulin enhancer binding protein membrane associated guanylate cyclase kinase mitogen activated protein kinase nitric oxide synthase phorbol 13 acetate 12 myristate phospholipase C receptor subtype adaptation addiction anxiety disorder brain cell membrane permeability central nervous system depression drug targeting hippocampus human hypothalamus hypophysis adrenal system limbic cortex mental disease mood disorder neuroanatomy neuropharmacology nonhuman priority journal review signal transduction stress Animals Brain Corticotropin-Releasing Hormone Humans Mental Disorders Signal Transduction Stress Stress, Physiological Corticotrophin-releasing factor (CRF) is the key mediator of the central nervous system response needed to adapt to stress. If adaptation fails, hypersecretion of CRF continues and produces, via CRF type 1 receptors, symptoms pertaining to cognition, appetite, sleep and anxiety, implicating CRF as a causal factor in affective disorders. Clinical studies with CRF receptor 1 antagonists support a novel pharmacological strategy for treating stress-related disorders. Here we summarize recent information obtained on CRF receptor 1 signaling and propose the concept of a more focused pharmacological intervention based on the signaling pathways involved. Recent findings suggest that CRF activates, via the same CRF receptor 1, different signaling pathways in specific areas of the brain. This intracellular and neuroanatomical signaling specificity will facilitate the search for less pleiotropic antagonists and new chemical compounds that modulate signal transduction in a site-specific manner. © 2006 Elsevier Ltd. All rights reserved. 2006 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01656147_v27_n10_p531_Arzt http://hdl.handle.net/20.500.12110/paper_01656147_v27_n10_p531_Arzt |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
calcium ion corticotropin releasing factor corticotropin releasing factor receptor 1 cyclic AMP dependent protein kinase immunoglobulin enhancer binding protein membrane associated guanylate cyclase kinase mitogen activated protein kinase nitric oxide synthase phorbol 13 acetate 12 myristate phospholipase C receptor subtype adaptation addiction anxiety disorder brain cell membrane permeability central nervous system depression drug targeting hippocampus human hypothalamus hypophysis adrenal system limbic cortex mental disease mood disorder neuroanatomy neuropharmacology nonhuman priority journal review signal transduction stress Animals Brain Corticotropin-Releasing Hormone Humans Mental Disorders Signal Transduction Stress Stress, Physiological |
| spellingShingle |
calcium ion corticotropin releasing factor corticotropin releasing factor receptor 1 cyclic AMP dependent protein kinase immunoglobulin enhancer binding protein membrane associated guanylate cyclase kinase mitogen activated protein kinase nitric oxide synthase phorbol 13 acetate 12 myristate phospholipase C receptor subtype adaptation addiction anxiety disorder brain cell membrane permeability central nervous system depression drug targeting hippocampus human hypothalamus hypophysis adrenal system limbic cortex mental disease mood disorder neuroanatomy neuropharmacology nonhuman priority journal review signal transduction stress Animals Brain Corticotropin-Releasing Hormone Humans Mental Disorders Signal Transduction Stress Stress, Physiological CRF signaling: molecular specificity for drug targeting in the CNS |
| topic_facet |
calcium ion corticotropin releasing factor corticotropin releasing factor receptor 1 cyclic AMP dependent protein kinase immunoglobulin enhancer binding protein membrane associated guanylate cyclase kinase mitogen activated protein kinase nitric oxide synthase phorbol 13 acetate 12 myristate phospholipase C receptor subtype adaptation addiction anxiety disorder brain cell membrane permeability central nervous system depression drug targeting hippocampus human hypothalamus hypophysis adrenal system limbic cortex mental disease mood disorder neuroanatomy neuropharmacology nonhuman priority journal review signal transduction stress Animals Brain Corticotropin-Releasing Hormone Humans Mental Disorders Signal Transduction Stress Stress, Physiological |
| description |
Corticotrophin-releasing factor (CRF) is the key mediator of the central nervous system response needed to adapt to stress. If adaptation fails, hypersecretion of CRF continues and produces, via CRF type 1 receptors, symptoms pertaining to cognition, appetite, sleep and anxiety, implicating CRF as a causal factor in affective disorders. Clinical studies with CRF receptor 1 antagonists support a novel pharmacological strategy for treating stress-related disorders. Here we summarize recent information obtained on CRF receptor 1 signaling and propose the concept of a more focused pharmacological intervention based on the signaling pathways involved. Recent findings suggest that CRF activates, via the same CRF receptor 1, different signaling pathways in specific areas of the brain. This intracellular and neuroanatomical signaling specificity will facilitate the search for less pleiotropic antagonists and new chemical compounds that modulate signal transduction in a site-specific manner. © 2006 Elsevier Ltd. All rights reserved. |
| title |
CRF signaling: molecular specificity for drug targeting in the CNS |
| title_short |
CRF signaling: molecular specificity for drug targeting in the CNS |
| title_full |
CRF signaling: molecular specificity for drug targeting in the CNS |
| title_fullStr |
CRF signaling: molecular specificity for drug targeting in the CNS |
| title_full_unstemmed |
CRF signaling: molecular specificity for drug targeting in the CNS |
| title_sort |
crf signaling: molecular specificity for drug targeting in the cns |
| publishDate |
2006 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01656147_v27_n10_p531_Arzt http://hdl.handle.net/20.500.12110/paper_01656147_v27_n10_p531_Arzt |
| _version_ |
1768545368894603264 |