Withanolides from Vassobia lorentzii

Eight new withanolides were isolated from the aerial parts of Vassobia lorentzii and characterized by spectroscopic methods and with the aid of molecular modeling. The compounds were identified as (17S,20R,22R)-5β,6β:18,20-diepoxy-18-hydroxy-1-oxowitha-2,5,24-trienolide (1); (17S,20R,22R)-18,20-epox...

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Autores principales:	Veleiro, Adriana Silvia, Burton, Gerardo
Publicado:	2000
Materias:	18,20 epoxy 18 methoxy 1,4 dioxowitha 2,5,24 trienolide 18,20 epoxy 4beta,18 dihydroxy 1 oxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 1,18 dioxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 18 methoxy 1 oxowitha 2,5,24 trienolide 5beta,6beta epoxy 4beta,18,20 trihydroxy 1 oxowitha 2,24 dienolide 5beta,6beta:18,20 diepoxy 18 hydroxy 1 oxowitha 2,5,24 trienolide plant extract unclassified drug Vassobia lorentzii extract withanolide article chemical structure chemotaxonomy extraction isomer molecular model nonhuman spectroscopy Animals Antimalarials Ergosterol Humans Lactones Magnetic Resonance Spectroscopy Plasmodium falciparum Solanaceae Vassobia
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v63_n10_p1329_Misico http://hdl.handle.net/20.500.12110/paper_01633864_v63_n10_p1329_Misico
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01633864_v63_n10_p1329_Misico
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spelling	paper:paper_01633864_v63_n10_p1329_Misico2023-06-08T15:14:13Z Withanolides from Vassobia lorentzii Veleiro, Adriana Silvia Burton, Gerardo 18,20 epoxy 18 methoxy 1,4 dioxowitha 2,5,24 trienolide 18,20 epoxy 4beta,18 dihydroxy 1 oxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 1,18 dioxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 18 methoxy 1 oxowitha 2,5,24 trienolide 5beta,6beta epoxy 4beta,18,20 trihydroxy 1 oxowitha 2,24 dienolide 5beta,6beta:18,20 diepoxy 18 hydroxy 1 oxowitha 2,5,24 trienolide plant extract unclassified drug Vassobia lorentzii extract withanolide article chemical structure chemotaxonomy extraction isomer molecular model nonhuman spectroscopy Animals Antimalarials Ergosterol Humans Lactones Magnetic Resonance Spectroscopy Plasmodium falciparum Solanaceae Vassobia Eight new withanolides were isolated from the aerial parts of Vassobia lorentzii and characterized by spectroscopic methods and with the aid of molecular modeling. The compounds were identified as (17S,20R,22R)-5β,6β:18,20-diepoxy-18-hydroxy-1-oxowitha-2,5,24-trienolide (1); (17S,20R,22R)-18,20-epoxy-4β,18-dihydroxy-1-oxowitha-2,5,24-trienolide (2); (17S,18R,20R,22R)-4β-hydroxy-18,20-epoxy-18-methoxy-1-oxowitha-2,5,24-trieno lide (3); (17S,18S,20R,22R)-4β-hydroxy-18,20-epoxy-18-methoxy-1-oxowitha-2,5,24-trieno lide (4); (17S,20R,22R)-4β-hydroxy-18,20-epoxy-1,18-dioxowitha-2,5,24-trienolide (5); (17S,18R,20R,22R)-18,20-epoxy-18-methoxy-1,4-dioxowitha-2,5,24-trienolide (6); (17S,18S,20R,22R)-18,20-epoxy-18-methoxy-1,4-dioxowitha-2,5,24-trienolide (7); and (17S,20R,22R)-5β,6β-epoxy-4β,18,20-trihydroxy-1-oxowitha-2,24-dienolide (8). Compounds 1 and 2 were obtained as epimeric mixtures at C-18. Fil:Veleiro, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2000 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v63_n10_p1329_Misico http://hdl.handle.net/20.500.12110/paper_01633864_v63_n10_p1329_Misico
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	18,20 epoxy 18 methoxy 1,4 dioxowitha 2,5,24 trienolide 18,20 epoxy 4beta,18 dihydroxy 1 oxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 1,18 dioxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 18 methoxy 1 oxowitha 2,5,24 trienolide 5beta,6beta epoxy 4beta,18,20 trihydroxy 1 oxowitha 2,24 dienolide 5beta,6beta:18,20 diepoxy 18 hydroxy 1 oxowitha 2,5,24 trienolide plant extract unclassified drug Vassobia lorentzii extract withanolide article chemical structure chemotaxonomy extraction isomer molecular model nonhuman spectroscopy Animals Antimalarials Ergosterol Humans Lactones Magnetic Resonance Spectroscopy Plasmodium falciparum Solanaceae Vassobia
spellingShingle	18,20 epoxy 18 methoxy 1,4 dioxowitha 2,5,24 trienolide 18,20 epoxy 4beta,18 dihydroxy 1 oxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 1,18 dioxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 18 methoxy 1 oxowitha 2,5,24 trienolide 5beta,6beta epoxy 4beta,18,20 trihydroxy 1 oxowitha 2,24 dienolide 5beta,6beta:18,20 diepoxy 18 hydroxy 1 oxowitha 2,5,24 trienolide plant extract unclassified drug Vassobia lorentzii extract withanolide article chemical structure chemotaxonomy extraction isomer molecular model nonhuman spectroscopy Animals Antimalarials Ergosterol Humans Lactones Magnetic Resonance Spectroscopy Plasmodium falciparum Solanaceae Vassobia Veleiro, Adriana Silvia Burton, Gerardo Withanolides from Vassobia lorentzii
topic_facet	18,20 epoxy 18 methoxy 1,4 dioxowitha 2,5,24 trienolide 18,20 epoxy 4beta,18 dihydroxy 1 oxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 1,18 dioxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 18 methoxy 1 oxowitha 2,5,24 trienolide 5beta,6beta epoxy 4beta,18,20 trihydroxy 1 oxowitha 2,24 dienolide 5beta,6beta:18,20 diepoxy 18 hydroxy 1 oxowitha 2,5,24 trienolide plant extract unclassified drug Vassobia lorentzii extract withanolide article chemical structure chemotaxonomy extraction isomer molecular model nonhuman spectroscopy Animals Antimalarials Ergosterol Humans Lactones Magnetic Resonance Spectroscopy Plasmodium falciparum Solanaceae Vassobia
description	Eight new withanolides were isolated from the aerial parts of Vassobia lorentzii and characterized by spectroscopic methods and with the aid of molecular modeling. The compounds were identified as (17S,20R,22R)-5β,6β:18,20-diepoxy-18-hydroxy-1-oxowitha-2,5,24-trienolide (1); (17S,20R,22R)-18,20-epoxy-4β,18-dihydroxy-1-oxowitha-2,5,24-trienolide (2); (17S,18R,20R,22R)-4β-hydroxy-18,20-epoxy-18-methoxy-1-oxowitha-2,5,24-trieno lide (3); (17S,18S,20R,22R)-4β-hydroxy-18,20-epoxy-18-methoxy-1-oxowitha-2,5,24-trieno lide (4); (17S,20R,22R)-4β-hydroxy-18,20-epoxy-1,18-dioxowitha-2,5,24-trienolide (5); (17S,18R,20R,22R)-18,20-epoxy-18-methoxy-1,4-dioxowitha-2,5,24-trienolide (6); (17S,18S,20R,22R)-18,20-epoxy-18-methoxy-1,4-dioxowitha-2,5,24-trienolide (7); and (17S,20R,22R)-5β,6β-epoxy-4β,18,20-trihydroxy-1-oxowitha-2,24-dienolide (8). Compounds 1 and 2 were obtained as epimeric mixtures at C-18.
author	Veleiro, Adriana Silvia Burton, Gerardo
author_facet	Veleiro, Adriana Silvia Burton, Gerardo
author_sort	Veleiro, Adriana Silvia
title	Withanolides from Vassobia lorentzii
title_short	Withanolides from Vassobia lorentzii
title_full	Withanolides from Vassobia lorentzii
title_fullStr	Withanolides from Vassobia lorentzii
title_full_unstemmed	Withanolides from Vassobia lorentzii
title_sort	withanolides from vassobia lorentzii
publishDate	2000
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v63_n10_p1329_Misico http://hdl.handle.net/20.500.12110/paper_01633864_v63_n10_p1329_Misico
work_keys_str_mv	AT veleiroadrianasilvia withanolidesfromvassobialorentzii AT burtongerardo withanolidesfromvassobialorentzii
_version_	1768542264128176128

Withanolides from Vassobia lorentzii

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