Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus
On sudden presentation of a passing shadow, the crab Chasmagnathus granulatus reacts with an escape response that habituates after repeating the same stimulus. In a first series of experiments, a range of naloxone (NX) doses (0.8, 2.4, 3.2, and 6.2 μg/g) was injected into crabs 15 min before one 15-...
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1990
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01631047_v53_n1_p113_Romano http://hdl.handle.net/20.500.12110/paper_01631047_v53_n1_p113_Romano |
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paper:paper_01631047_v53_n1_p113_Romano2023-06-08T15:13:43Z Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus Romano, Arturo Gabriel Lozada, Mariana naloxone amphibia animal experiment arthropod article behavior conditioning crab habituation nonhuman psychological aspect Animal Arousal Brachyura Dose-Response Relationship, Drug Fear Habituation (Psychophysiology) Male Naloxone Receptors, Opioid Support, Non-U.S. Gov't On sudden presentation of a passing shadow, the crab Chasmagnathus granulatus reacts with an escape response that habituates after repeating the same stimulus. In a first series of experiments, a range of naloxone (NX) doses (0.8, 2.4, 3.2, and 6.2 μg/g) was injected into crabs 15 min before one 15-trial habituation session. An enhancing effect of 3.2 μg NX/g on responsiveness appeared over trials, that cannot be explained either by a ceiling effect or by a delay in peak drug action. Two doses below 3.2 μg/g and one dose above had no significant effect. Results from a second series of experiments showed that the 3.2 μg NX/g effect vanishes after 15 trials (1 h after injection). The hypothesis that crab's habitution involves the action of an endogenous opioid mechanism is put forward to account for the naloxone pretreatment effect. © 1978 Academic Press, Inc. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Lozada, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1990 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01631047_v53_n1_p113_Romano http://hdl.handle.net/20.500.12110/paper_01631047_v53_n1_p113_Romano |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
naloxone amphibia animal experiment arthropod article behavior conditioning crab habituation nonhuman psychological aspect Animal Arousal Brachyura Dose-Response Relationship, Drug Fear Habituation (Psychophysiology) Male Naloxone Receptors, Opioid Support, Non-U.S. Gov't |
spellingShingle |
naloxone amphibia animal experiment arthropod article behavior conditioning crab habituation nonhuman psychological aspect Animal Arousal Brachyura Dose-Response Relationship, Drug Fear Habituation (Psychophysiology) Male Naloxone Receptors, Opioid Support, Non-U.S. Gov't Romano, Arturo Gabriel Lozada, Mariana Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus |
topic_facet |
naloxone amphibia animal experiment arthropod article behavior conditioning crab habituation nonhuman psychological aspect Animal Arousal Brachyura Dose-Response Relationship, Drug Fear Habituation (Psychophysiology) Male Naloxone Receptors, Opioid Support, Non-U.S. Gov't |
description |
On sudden presentation of a passing shadow, the crab Chasmagnathus granulatus reacts with an escape response that habituates after repeating the same stimulus. In a first series of experiments, a range of naloxone (NX) doses (0.8, 2.4, 3.2, and 6.2 μg/g) was injected into crabs 15 min before one 15-trial habituation session. An enhancing effect of 3.2 μg NX/g on responsiveness appeared over trials, that cannot be explained either by a ceiling effect or by a delay in peak drug action. Two doses below 3.2 μg/g and one dose above had no significant effect. Results from a second series of experiments showed that the 3.2 μg NX/g effect vanishes after 15 trials (1 h after injection). The hypothesis that crab's habitution involves the action of an endogenous opioid mechanism is put forward to account for the naloxone pretreatment effect. © 1978 Academic Press, Inc. |
author |
Romano, Arturo Gabriel Lozada, Mariana |
author_facet |
Romano, Arturo Gabriel Lozada, Mariana |
author_sort |
Romano, Arturo Gabriel |
title |
Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus |
title_short |
Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus |
title_full |
Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus |
title_fullStr |
Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus |
title_full_unstemmed |
Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus |
title_sort |
effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus |
publishDate |
1990 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01631047_v53_n1_p113_Romano http://hdl.handle.net/20.500.12110/paper_01631047_v53_n1_p113_Romano |
work_keys_str_mv |
AT romanoarturogabriel effectofnaloxonepretreatmentonhabituationinthecrabchasmagnathusgranulatus AT lozadamariana effectofnaloxonepretreatmentonhabituationinthecrabchasmagnathusgranulatus |
_version_ |
1768545595184644096 |