The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays

The [Ru II(Hedta)NO +] complex is a diamagnetic species crystallizing in a distorted octahedral geometry, with the Ru-N(O) length 1.756(4) Å and the RuNO angle 172.3(4)°. The complex contains one protonated carboxylate (pK a = 2.7 ± 0.1). The [Ru II(Hedta)NO +] complex undergoes a nitrosyl-centered...

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Publicado:	2004
Materias:	Nitrosyl reactivity NO-donors Nucleophilic reactivity Ruthenium nitrosyl Vasodilator activity carboxylic acid hydroxide metal nitric oxide nitroprusside sodium ruthenium derivative addition reaction animal experiment article bioaccumulation bioassay chemical reaction controlled study crystallization death drug effect drug structure electricity electrochemistry electron endothelium geometry injection kidney liver male nonhuman parameter plasma proton transport rat reaction analysis reduction sample structure analysis time toxicity urine vascular ring vasodilatation Animals Crystallography, X-Ray Edetic Acid Electrochemistry Male Mice Models, Molecular Molecular Conformation Nitric Oxide Ruthenium Tissue Distribution Xenox
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01620134_v98_n11_p1921_Zanichelli http://hdl.handle.net/20.500.12110/paper_01620134_v98_n11_p1921_Zanichelli
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	paper:paper_01620134_v98_n11_p1921_Zanichelli2023-06-08T15:13:37Z The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays Nitrosyl reactivity NO-donors Nucleophilic reactivity Ruthenium nitrosyl Vasodilator activity carboxylic acid hydroxide metal nitric oxide nitroprusside sodium ruthenium derivative addition reaction animal experiment article bioaccumulation bioassay chemical reaction controlled study crystallization death drug effect drug structure electricity electrochemistry electron endothelium geometry injection kidney liver male nonhuman parameter plasma proton transport rat reaction analysis reduction sample structure analysis time toxicity urine vascular ring vasodilatation Animals Crystallography, X-Ray Edetic Acid Electrochemistry Male Mice Models, Molecular Molecular Conformation Nitric Oxide Ruthenium Tissue Distribution Xenox The [Ru II(Hedta)NO +] complex is a diamagnetic species crystallizing in a distorted octahedral geometry, with the Ru-N(O) length 1.756(4) Å and the RuNO angle 172.3(4)°. The complex contains one protonated carboxylate (pK a = 2.7 ± 0.1). The [Ru II(Hedta)NO +] complex undergoes a nitrosyl-centered one-electron reduction (chemical or electrochemical), with E NO+/NO = -0.31 V vs SCE (I = 0.2 M, pH 1), yielding [Ru II(Hedta)NO] -, which aquates slowly: k -NO = 2.1 ± 0.4 × 10 -3 s -1 (pH 1.0, I = 0.2 M, CF 3COOH/NaCF 3COO, 25°C). At pHs > 12, the predominant species, [Ru II(edta)NO] -, reacts according to [Ru II(edta) NO] - + 2OH - ⇒ [Ru II(edta)NO 2] 3-, with K eq = 1.0 ± 0.4 × 10 3 M -2 (I = 1.0 M, NaCl; T = 25.0 ± 0.1°C). The rate-law is first order in each of the reactants for most reaction conditions, with k OH - = 4.35 ± 0.02 M -1 s -1 (25.0°C), assignable mechanistically to the elementary step comprising the attack of one OH - on [Ru II(edta)NO] -, with subsequent fast deprotonation of the [Ru II(edta) NO 2H] 2- intermediate. The activation parameters were ΔH # = 60 ± 1 kJ/mol, ΔS # = -31 ± 3 J/K mol, consistent with a nucleophilic addition process between likely charged ions. In the toxicity up-and-down tests performed with Swiss mice, no death was observed in all the doses administered (3-9.08 × 10 -5 mol/kg). The biodistribution tests performed with Wistar male rats showed metal in the liver, kidney, urine and plasma. Eight hours after the injection no metal was detected in the samples. The vasodilator effect of [Ru II(edta)NO] - was studied in aortic rings without endothelium, and was compared with sodium nitroprusside (SNP). The times of maximal effects of [Ru II(edta)NO] - and SNP were 2 h and 12 min, respectively, suggesting that [Ru II(edta)NO] - releases NO slowly to the medium in comparison with SNP. © 2004 Elsevier Inc. All rights reserved. 2004 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01620134_v98_n11_p1921_Zanichelli http://hdl.handle.net/20.500.12110/paper_01620134_v98_n11_p1921_Zanichelli
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Nitrosyl reactivity NO-donors Nucleophilic reactivity Ruthenium nitrosyl Vasodilator activity carboxylic acid hydroxide metal nitric oxide nitroprusside sodium ruthenium derivative addition reaction animal experiment article bioaccumulation bioassay chemical reaction controlled study crystallization death drug effect drug structure electricity electrochemistry electron endothelium geometry injection kidney liver male nonhuman parameter plasma proton transport rat reaction analysis reduction sample structure analysis time toxicity urine vascular ring vasodilatation Animals Crystallography, X-Ray Edetic Acid Electrochemistry Male Mice Models, Molecular Molecular Conformation Nitric Oxide Ruthenium Tissue Distribution Xenox
spellingShingle	Nitrosyl reactivity NO-donors Nucleophilic reactivity Ruthenium nitrosyl Vasodilator activity carboxylic acid hydroxide metal nitric oxide nitroprusside sodium ruthenium derivative addition reaction animal experiment article bioaccumulation bioassay chemical reaction controlled study crystallization death drug effect drug structure electricity electrochemistry electron endothelium geometry injection kidney liver male nonhuman parameter plasma proton transport rat reaction analysis reduction sample structure analysis time toxicity urine vascular ring vasodilatation Animals Crystallography, X-Ray Edetic Acid Electrochemistry Male Mice Models, Molecular Molecular Conformation Nitric Oxide Ruthenium Tissue Distribution Xenox The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays
topic_facet	Nitrosyl reactivity NO-donors Nucleophilic reactivity Ruthenium nitrosyl Vasodilator activity carboxylic acid hydroxide metal nitric oxide nitroprusside sodium ruthenium derivative addition reaction animal experiment article bioaccumulation bioassay chemical reaction controlled study crystallization death drug effect drug structure electricity electrochemistry electron endothelium geometry injection kidney liver male nonhuman parameter plasma proton transport rat reaction analysis reduction sample structure analysis time toxicity urine vascular ring vasodilatation Animals Crystallography, X-Ray Edetic Acid Electrochemistry Male Mice Models, Molecular Molecular Conformation Nitric Oxide Ruthenium Tissue Distribution Xenox
description	The [Ru II(Hedta)NO +] complex is a diamagnetic species crystallizing in a distorted octahedral geometry, with the Ru-N(O) length 1.756(4) Å and the RuNO angle 172.3(4)°. The complex contains one protonated carboxylate (pK a = 2.7 ± 0.1). The [Ru II(Hedta)NO +] complex undergoes a nitrosyl-centered one-electron reduction (chemical or electrochemical), with E NO+/NO = -0.31 V vs SCE (I = 0.2 M, pH 1), yielding [Ru II(Hedta)NO] -, which aquates slowly: k -NO = 2.1 ± 0.4 × 10 -3 s -1 (pH 1.0, I = 0.2 M, CF 3COOH/NaCF 3COO, 25°C). At pHs > 12, the predominant species, [Ru II(edta)NO] -, reacts according to [Ru II(edta) NO] - + 2OH - ⇒ [Ru II(edta)NO 2] 3-, with K eq = 1.0 ± 0.4 × 10 3 M -2 (I = 1.0 M, NaCl; T = 25.0 ± 0.1°C). The rate-law is first order in each of the reactants for most reaction conditions, with k OH - = 4.35 ± 0.02 M -1 s -1 (25.0°C), assignable mechanistically to the elementary step comprising the attack of one OH - on [Ru II(edta)NO] -, with subsequent fast deprotonation of the [Ru II(edta) NO 2H] 2- intermediate. The activation parameters were ΔH # = 60 ± 1 kJ/mol, ΔS # = -31 ± 3 J/K mol, consistent with a nucleophilic addition process between likely charged ions. In the toxicity up-and-down tests performed with Swiss mice, no death was observed in all the doses administered (3-9.08 × 10 -5 mol/kg). The biodistribution tests performed with Wistar male rats showed metal in the liver, kidney, urine and plasma. Eight hours after the injection no metal was detected in the samples. The vasodilator effect of [Ru II(edta)NO] - was studied in aortic rings without endothelium, and was compared with sodium nitroprusside (SNP). The times of maximal effects of [Ru II(edta)NO] - and SNP were 2 h and 12 min, respectively, suggesting that [Ru II(edta)NO] - releases NO slowly to the medium in comparison with SNP. © 2004 Elsevier Inc. All rights reserved.
title	The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays
title_short	The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays
title_full	The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays
title_fullStr	The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays
title_full_unstemmed	The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays
title_sort	[ru(hedta)no] 0,1- system: structure, chemical reactivity and biological assays
publishDate	2004
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01620134_v98_n11_p1921_Zanichelli http://hdl.handle.net/20.500.12110/paper_01620134_v98_n11_p1921_Zanichelli
_version_	1768545278010327040

The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays

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