A caged nicotine with nanosecond range kinetics and visible light sensitivity

We report the synthesis, characterization and applications of a ruthenium-bipyridine based caged nicotine. The complex [Ru(bpy)2(nic)2]2+ (where bpy=2,2' bipyridine and nic=nicotine (3-[(2S)-1-methylpyrrolidin-2-yl] pyridine)) releases nicotine with a quantum yield Φ=0.23 upon irradiation with...

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Detalles Bibliográficos
Autores principales: Filevich, Oscar, Salierno, Marcelo Javier, Etchenique, Roberto
Publicado: 2010
Materias:
Caged compound
Leech
NAChR
Neurotransmitter
Nicotine
Ruthenium complex
bipyridine
caged nicotine
nicotine
ruthenium
unclassified drug
article
complex formation
controlled study
cyclic potentiometry
irradiation
kinetics
leech
nonhuman
nuclear magnetic resonance spectroscopy
photolysis
quantum yield
synthesis
ultraviolet spectroscopy
Animals
Electrophysiology
Leeches
Light
Magnetic Resonance Spectroscopy
Models, Chemical
Neurons
Photochemistry
Photolysis
Ruthenium
Hirudinida
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01620134_v104_n12_p1248_Filevich
http://hdl.handle.net/20.500.12110/paper_01620134_v104_n12_p1248_Filevich
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_01620134_v104_n12_p1248_Filevich
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spelling paper:paper_01620134_v104_n12_p1248_Filevich2023-06-08T15:13:34Z A caged nicotine with nanosecond range kinetics and visible light sensitivity Filevich, Oscar Salierno, Marcelo Javier Etchenique, Roberto Caged compound Leech NAChR Neurotransmitter Nicotine Ruthenium complex bipyridine caged nicotine nicotine ruthenium unclassified drug article complex formation controlled study cyclic potentiometry irradiation kinetics leech nonhuman nuclear magnetic resonance spectroscopy photolysis quantum yield synthesis ultraviolet spectroscopy Animals Electrophysiology Leeches Light Magnetic Resonance Spectroscopy Models, Chemical Neurons Nicotine Photochemistry Photolysis Ruthenium Hirudinida We report the synthesis, characterization and applications of a ruthenium-bipyridine based caged nicotine. The complex [Ru(bpy)2(nic)2]2+ (where bpy=2,2' bipyridine and nic=nicotine (3-[(2S)-1-methylpyrrolidin-2-yl] pyridine)) releases nicotine with a quantum yield Φ=0.23 upon irradiation with biologically harmless, blue (473nm) or green (532nm) light. The photolysis reaction is clean and very fast, with a time constant of 17ns. The synthesis is simple and the obtained compound is characterized by NMR, UV-Vis spectroscopy and cyclic voltametry. We find that this compound is active in biological systems, being able to elicit action potentials in leech neurons. © 2010 Elsevier Inc. Fil:Filevich, O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Salierno, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Etchenique, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01620134_v104_n12_p1248_Filevich http://hdl.handle.net/20.500.12110/paper_01620134_v104_n12_p1248_Filevich
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Caged compound
Leech
NAChR
Neurotransmitter
Nicotine
Ruthenium complex
bipyridine
caged nicotine
nicotine
ruthenium
unclassified drug
article
complex formation
controlled study
cyclic potentiometry
irradiation
kinetics
leech
nonhuman
nuclear magnetic resonance spectroscopy
photolysis
quantum yield
synthesis
ultraviolet spectroscopy
Animals
Electrophysiology
Leeches
Light
Magnetic Resonance Spectroscopy
Models, Chemical
Neurons
Nicotine
Photochemistry
Photolysis
Ruthenium
Hirudinida
spellingShingle Caged compound
Leech
NAChR
Neurotransmitter
Nicotine
Ruthenium complex
bipyridine
caged nicotine
nicotine
ruthenium
unclassified drug
article
complex formation
controlled study
cyclic potentiometry
irradiation
kinetics
leech
nonhuman
nuclear magnetic resonance spectroscopy
photolysis
quantum yield
synthesis
ultraviolet spectroscopy
Animals
Electrophysiology
Leeches
Light
Magnetic Resonance Spectroscopy
Models, Chemical
Neurons
Nicotine
Photochemistry
Photolysis
Ruthenium
Hirudinida
Filevich, Oscar
Salierno, Marcelo Javier
Etchenique, Roberto
A caged nicotine with nanosecond range kinetics and visible light sensitivity
topic_facet Caged compound
Leech
NAChR
Neurotransmitter
Nicotine
Ruthenium complex
bipyridine
caged nicotine
nicotine
ruthenium
unclassified drug
article
complex formation
controlled study
cyclic potentiometry
irradiation
kinetics
leech
nonhuman
nuclear magnetic resonance spectroscopy
photolysis
quantum yield
synthesis
ultraviolet spectroscopy
Animals
Electrophysiology
Leeches
Light
Magnetic Resonance Spectroscopy
Models, Chemical
Neurons
Nicotine
Photochemistry
Photolysis
Ruthenium
Hirudinida
description We report the synthesis, characterization and applications of a ruthenium-bipyridine based caged nicotine. The complex [Ru(bpy)2(nic)2]2+ (where bpy=2,2' bipyridine and nic=nicotine (3-[(2S)-1-methylpyrrolidin-2-yl] pyridine)) releases nicotine with a quantum yield Φ=0.23 upon irradiation with biologically harmless, blue (473nm) or green (532nm) light. The photolysis reaction is clean and very fast, with a time constant of 17ns. The synthesis is simple and the obtained compound is characterized by NMR, UV-Vis spectroscopy and cyclic voltametry. We find that this compound is active in biological systems, being able to elicit action potentials in leech neurons. © 2010 Elsevier Inc.
author Filevich, Oscar
Salierno, Marcelo Javier
Etchenique, Roberto
author_facet Filevich, Oscar
Salierno, Marcelo Javier
Etchenique, Roberto
author_sort Filevich, Oscar
title A caged nicotine with nanosecond range kinetics and visible light sensitivity
title_short A caged nicotine with nanosecond range kinetics and visible light sensitivity
title_full A caged nicotine with nanosecond range kinetics and visible light sensitivity
title_fullStr A caged nicotine with nanosecond range kinetics and visible light sensitivity
title_full_unstemmed A caged nicotine with nanosecond range kinetics and visible light sensitivity
title_sort caged nicotine with nanosecond range kinetics and visible light sensitivity
publishDate 2010
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01620134_v104_n12_p1248_Filevich
http://hdl.handle.net/20.500.12110/paper_01620134_v104_n12_p1248_Filevich
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