Zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure
The correlation between blood lead level (BLL), δ-aminolevulinate dehydratase (ALA-D) activity, and other common biochemical parameters used to assess a plumbism diagnosis have been carefully analyzed, with the aim of correctly interpreting the data handled in the laboratory. No correlation was obse...
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1995
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01476513_v32_n3_p267_Polo http://hdl.handle.net/20.500.12110/paper_01476513_v32_n3_p267_Polo |
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paper:paper_01476513_v32_n3_p267_Polo2023-06-08T15:12:56Z Zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure Afonso, Susana Graciela Rossetti, María Victoria Batlle, Alcira María del Carmen lead porphobilinogen synthase porphyrin zinc article enzyme activity enzyme assay erythrocyte erythropoiesis heme synthesis human human cell lead blood level lead poisoning Adult Alanine Binding Sites Child Child, Preschool Erythrocytes Female Hemoglobins Humans Lead Lead Poisoning Male Porphobilinogen Porphobilinogen Synthase Porphyrins Reference Standards Reproducibility of Results Spectrophotometry, Atomic Zinc The correlation between blood lead level (BLL), δ-aminolevulinate dehydratase (ALA-D) activity, and other common biochemical parameters used to assess a plumbism diagnosis have been carefully analyzed, with the aim of correctly interpreting the data handled in the laboratory. No correlation was observed between BLL and free erythrocyte porphyrins. In the case of ALA-D or Zn-reactivated ALA-D despite the direct correlation with BLL, the curve follows a potential or a logarithmic line, which is not the best to calculate BLL. The so-called Zn-ALA-D-reactivation index (iZn) has been defined as the ratio between the activity of Zn-reactivated ALA-D and the activity of ALA-D. The plot of BLL against the iZn revealed a very good linear relationship which allows an estimate of BLL with reasonable accuracy within a very wide range. © 1995 by Academic Press, Inc. Fil:Afonso, S.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rossetti, M.V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Batlle, A.M.D.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1995 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01476513_v32_n3_p267_Polo http://hdl.handle.net/20.500.12110/paper_01476513_v32_n3_p267_Polo |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
lead porphobilinogen synthase porphyrin zinc article enzyme activity enzyme assay erythrocyte erythropoiesis heme synthesis human human cell lead blood level lead poisoning Adult Alanine Binding Sites Child Child, Preschool Erythrocytes Female Hemoglobins Humans Lead Lead Poisoning Male Porphobilinogen Porphobilinogen Synthase Porphyrins Reference Standards Reproducibility of Results Spectrophotometry, Atomic Zinc |
| spellingShingle |
lead porphobilinogen synthase porphyrin zinc article enzyme activity enzyme assay erythrocyte erythropoiesis heme synthesis human human cell lead blood level lead poisoning Adult Alanine Binding Sites Child Child, Preschool Erythrocytes Female Hemoglobins Humans Lead Lead Poisoning Male Porphobilinogen Porphobilinogen Synthase Porphyrins Reference Standards Reproducibility of Results Spectrophotometry, Atomic Zinc Afonso, Susana Graciela Rossetti, María Victoria Batlle, Alcira María del Carmen Zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure |
| topic_facet |
lead porphobilinogen synthase porphyrin zinc article enzyme activity enzyme assay erythrocyte erythropoiesis heme synthesis human human cell lead blood level lead poisoning Adult Alanine Binding Sites Child Child, Preschool Erythrocytes Female Hemoglobins Humans Lead Lead Poisoning Male Porphobilinogen Porphobilinogen Synthase Porphyrins Reference Standards Reproducibility of Results Spectrophotometry, Atomic Zinc |
| description |
The correlation between blood lead level (BLL), δ-aminolevulinate dehydratase (ALA-D) activity, and other common biochemical parameters used to assess a plumbism diagnosis have been carefully analyzed, with the aim of correctly interpreting the data handled in the laboratory. No correlation was observed between BLL and free erythrocyte porphyrins. In the case of ALA-D or Zn-reactivated ALA-D despite the direct correlation with BLL, the curve follows a potential or a logarithmic line, which is not the best to calculate BLL. The so-called Zn-ALA-D-reactivation index (iZn) has been defined as the ratio between the activity of Zn-reactivated ALA-D and the activity of ALA-D. The plot of BLL against the iZn revealed a very good linear relationship which allows an estimate of BLL with reasonable accuracy within a very wide range. © 1995 by Academic Press, Inc. |
| author |
Afonso, Susana Graciela Rossetti, María Victoria Batlle, Alcira María del Carmen |
| author_facet |
Afonso, Susana Graciela Rossetti, María Victoria Batlle, Alcira María del Carmen |
| author_sort |
Afonso, Susana Graciela |
| title |
Zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure |
| title_short |
Zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure |
| title_full |
Zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure |
| title_fullStr |
Zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure |
| title_full_unstemmed |
Zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure |
| title_sort |
zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure |
| publishDate |
1995 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01476513_v32_n3_p267_Polo http://hdl.handle.net/20.500.12110/paper_01476513_v32_n3_p267_Polo |
| work_keys_str_mv |
AT afonsosusanagraciela zincaminolevulinicaciddehydratasereactivationindexasatoolfordiagnosisofleadexposure AT rossettimariavictoria zincaminolevulinicaciddehydratasereactivationindexasatoolfordiagnosisofleadexposure AT batllealciramariadelcarmen zincaminolevulinicaciddehydratasereactivationindexasatoolfordiagnosisofleadexposure |
| _version_ |
1768546717894967296 |