Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus

Estrogenic chemicals are often detected in the aquatic environment and can negatively affect animal development and reproduction. In teleost fishes, the hormonal regulation during a critical period of larval development has a strong influence on gonadal sex differentiation; thus this process may be...

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Autores principales:	Meijide, Fernando Javier, Rey Vázquez, Graciela, Piazza, Yanina Grisel, Babay, Paola Alejandra, Itria, Raúl Fabio, Lo Nostro, Fabiana Laura
Publicado:	2016
Materias:	Acute toxicity Environmental estrogens Gonad development Sex differentiation Teleosts Testicular oocytes 4 tert octylphenol estradiol 4-nonylphenol 4-tert-octylphenol estrogen phenol derivative biomarker cichlid estrogenic compound larval development pollution effect pollution exposure toxicity acute toxicity adult animal cell animal experiment animal tissue Article Cichlasoma dimerus concentration (parameters) controlled study female gonad development larval stage male nonhuman oocyte ovary development sex differentiation spermatogenesis testis development animal drug effects growth, development and aging larva ovary testis Animalia Cichlasoma Teleostei Animals Cichlids Estradiol Estrogens Female Larva Male Ovary Phenols Sex Differentiation Testis
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01476513_v124_n_p82_Meijide http://hdl.handle.net/20.500.12110/paper_01476513_v124_n_p82_Meijide
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01476513_v124_n_p82_Meijide
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spelling	paper:paper_01476513_v124_n_p82_Meijide2023-06-08T15:12:51Z Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus Meijide, Fernando Javier Rey Vázquez, Graciela Piazza, Yanina Grisel Babay, Paola Alejandra Itria, Raúl Fabio Lo Nostro, Fabiana Laura Acute toxicity Environmental estrogens Gonad development Sex differentiation Teleosts Testicular oocytes 4 tert octylphenol estradiol 4-nonylphenol 4-tert-octylphenol estradiol estrogen phenol derivative biomarker cichlid estrogenic compound larval development pollution effect pollution exposure toxicity acute toxicity adult animal cell animal experiment animal tissue Article Cichlasoma dimerus cichlid concentration (parameters) controlled study female gonad development larval stage male nonhuman oocyte ovary development sex differentiation spermatogenesis testis development animal cichlid drug effects growth, development and aging larva ovary testis Animalia Cichlasoma Teleostei Animals Cichlids Estradiol Estrogens Female Larva Male Ovary Phenols Sex Differentiation Testis Estrogenic chemicals are often detected in the aquatic environment and can negatively affect animal development and reproduction. In teleost fishes, the hormonal regulation during a critical period of larval development has a strong influence on gonadal sex differentiation; thus this process may be affected by the exposure to environmental estrogens. In this study, we first assessed the lethal acute toxicity of the natural estrogen 17β-estradiol (E2) and the weaker estrogen mimics 4-tert-octylphenol (OP) and 4-nonylphenol (NP) on larval stages of the South American cichlid fish Cichlasoma dimerus. In a further experiment, we analyzed the effects of chronic waterborne exposure to E2 and OP on gonad development and sex differentiation. Exposure to high concentrations of E2 had a pronounced feminizing effect directing sex differentiation towards ovarian development, while testis development was inhibited at a lower, environmentally relevant concentration. Among OP-exposed fish, 15-38.5% of the males exhibited testicular oocytes (TOs), a commonly reported biomarker of estrogenic exposure. However, since TOs were also recorded in control males and the proportion of males with TOs was not significantly higher in OP treatments, their occurrence could not be attributed to OP exposure. In addition, TOs did not seem to impair male gonad development and functionality since normal spermatogenesis was observed in testes of OP-treated fish. These results indicate that E2 occurring in the South American aquatic environment may affect male reproductive development and pose a risk for wild C. dimerus, especially under prolonged exposure, while the effects of weaker xenoestrogens such as OP would be negligible for gonad development in this species. As illustrated by this study, the natural occurrence of TOs indicates that conclusions concerning the causes of this phenomenon must be drawn with care. © 2015 Elsevier Inc. Fil:Meijide, F.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rey Vázquez, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Piazza, Y.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Babay, P.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Itria, R.F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Lo Nostro, F.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01476513_v124_n_p82_Meijide http://hdl.handle.net/20.500.12110/paper_01476513_v124_n_p82_Meijide
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Acute toxicity Environmental estrogens Gonad development Sex differentiation Teleosts Testicular oocytes 4 tert octylphenol estradiol 4-nonylphenol 4-tert-octylphenol estradiol estrogen phenol derivative biomarker cichlid estrogenic compound larval development pollution effect pollution exposure toxicity acute toxicity adult animal cell animal experiment animal tissue Article Cichlasoma dimerus cichlid concentration (parameters) controlled study female gonad development larval stage male nonhuman oocyte ovary development sex differentiation spermatogenesis testis development animal cichlid drug effects growth, development and aging larva ovary testis Animalia Cichlasoma Teleostei Animals Cichlids Estradiol Estrogens Female Larva Male Ovary Phenols Sex Differentiation Testis
spellingShingle	Acute toxicity Environmental estrogens Gonad development Sex differentiation Teleosts Testicular oocytes 4 tert octylphenol estradiol 4-nonylphenol 4-tert-octylphenol estradiol estrogen phenol derivative biomarker cichlid estrogenic compound larval development pollution effect pollution exposure toxicity acute toxicity adult animal cell animal experiment animal tissue Article Cichlasoma dimerus cichlid concentration (parameters) controlled study female gonad development larval stage male nonhuman oocyte ovary development sex differentiation spermatogenesis testis development animal cichlid drug effects growth, development and aging larva ovary testis Animalia Cichlasoma Teleostei Animals Cichlids Estradiol Estrogens Female Larva Male Ovary Phenols Sex Differentiation Testis Meijide, Fernando Javier Rey Vázquez, Graciela Piazza, Yanina Grisel Babay, Paola Alejandra Itria, Raúl Fabio Lo Nostro, Fabiana Laura Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus
topic_facet	Acute toxicity Environmental estrogens Gonad development Sex differentiation Teleosts Testicular oocytes 4 tert octylphenol estradiol 4-nonylphenol 4-tert-octylphenol estradiol estrogen phenol derivative biomarker cichlid estrogenic compound larval development pollution effect pollution exposure toxicity acute toxicity adult animal cell animal experiment animal tissue Article Cichlasoma dimerus cichlid concentration (parameters) controlled study female gonad development larval stage male nonhuman oocyte ovary development sex differentiation spermatogenesis testis development animal cichlid drug effects growth, development and aging larva ovary testis Animalia Cichlasoma Teleostei Animals Cichlids Estradiol Estrogens Female Larva Male Ovary Phenols Sex Differentiation Testis
description	Estrogenic chemicals are often detected in the aquatic environment and can negatively affect animal development and reproduction. In teleost fishes, the hormonal regulation during a critical period of larval development has a strong influence on gonadal sex differentiation; thus this process may be affected by the exposure to environmental estrogens. In this study, we first assessed the lethal acute toxicity of the natural estrogen 17β-estradiol (E2) and the weaker estrogen mimics 4-tert-octylphenol (OP) and 4-nonylphenol (NP) on larval stages of the South American cichlid fish Cichlasoma dimerus. In a further experiment, we analyzed the effects of chronic waterborne exposure to E2 and OP on gonad development and sex differentiation. Exposure to high concentrations of E2 had a pronounced feminizing effect directing sex differentiation towards ovarian development, while testis development was inhibited at a lower, environmentally relevant concentration. Among OP-exposed fish, 15-38.5% of the males exhibited testicular oocytes (TOs), a commonly reported biomarker of estrogenic exposure. However, since TOs were also recorded in control males and the proportion of males with TOs was not significantly higher in OP treatments, their occurrence could not be attributed to OP exposure. In addition, TOs did not seem to impair male gonad development and functionality since normal spermatogenesis was observed in testes of OP-treated fish. These results indicate that E2 occurring in the South American aquatic environment may affect male reproductive development and pose a risk for wild C. dimerus, especially under prolonged exposure, while the effects of weaker xenoestrogens such as OP would be negligible for gonad development in this species. As illustrated by this study, the natural occurrence of TOs indicates that conclusions concerning the causes of this phenomenon must be drawn with care. © 2015 Elsevier Inc.
author	Meijide, Fernando Javier Rey Vázquez, Graciela Piazza, Yanina Grisel Babay, Paola Alejandra Itria, Raúl Fabio Lo Nostro, Fabiana Laura
author_facet	Meijide, Fernando Javier Rey Vázquez, Graciela Piazza, Yanina Grisel Babay, Paola Alejandra Itria, Raúl Fabio Lo Nostro, Fabiana Laura
author_sort	Meijide, Fernando Javier
title	Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus
title_short	Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus
title_full	Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus
title_fullStr	Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus
title_full_unstemmed	Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus
title_sort	effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the south american cichlid fish cichlasoma dimerus
publishDate	2016
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01476513_v124_n_p82_Meijide http://hdl.handle.net/20.500.12110/paper_01476513_v124_n_p82_Meijide
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Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus

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