Experimental infection of suckling mice with a host range mutant of junin virus

Experimental infection of three mouse strains with a non‐pathogenic mutant of Junin virus named C167 was compared with respect to the parental XJC13 strain. After intracerebral (ic) or intraperitoneal inoculation, XJC13 was highly virulent for 2 day‐old C3H/HeJ, OF1, and BALB/cJ mouse strains, where...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Scolaro, Luis Alberto, Mersich, Susana E., Damonte, Elsa Beatriz
Publicado:	1991
Materias:	attenuated mutant mouse strain susceptibility protection neutralizing antibody virus vaccine animal experiment animal model antibody detection article immune response immunization junin virus mouse newborn nonhuman priority journal provocation test virus attenuation virus infection virus mutant Animal Antibodies, Viral Arenaviruses, New World Disease Models, Animal Hemorrhagic Fever, American Kinetics Mice Mice, Inbred Strains Mutation Neutralization Tests Plaque Assay Support, Non-U.S. Gov't Vero Cells Virulence
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01466615_v34_n4_p237_Scolaro http://hdl.handle.net/20.500.12110/paper_01466615_v34_n4_p237_Scolaro
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01466615_v34_n4_p237_Scolaro
record_format	dspace
spelling	paper:paper_01466615_v34_n4_p237_Scolaro2023-06-08T15:12:32Z Experimental infection of suckling mice with a host range mutant of junin virus Scolaro, Luis Alberto Mersich, Susana E. Damonte, Elsa Beatriz attenuated mutant mouse strain susceptibility protection neutralizing antibody virus vaccine animal experiment animal model antibody detection article immune response immunization junin virus mouse newborn nonhuman priority journal provocation test virus attenuation virus infection virus mutant Animal Antibodies, Viral Arenaviruses, New World Disease Models, Animal Hemorrhagic Fever, American Kinetics Mice Mice, Inbred Strains Mutation Neutralization Tests Plaque Assay Support, Non-U.S. Gov't Vero Cells Virulence Experimental infection of three mouse strains with a non‐pathogenic mutant of Junin virus named C167 was compared with respect to the parental XJC13 strain. After intracerebral (ic) or intraperitoneal inoculation, XJC13 was highly virulent for 2 day‐old C3H/HeJ, OF1, and BALB/cJ mouse strains, whereas its derivative C167 was attenuated. Survival of the C167‐infected mouse was associated with a restricted replication at the site of inoculation which would impair spread of virus. Thus, the reduced virulence of C167 for suckling mice is independent of the mouse strain and the route of viral entry. When C167 was preinoculated ic I0 days before the challenge inoculation with XJC13 by the same route, mice were partially protected from lethal infection. Since neutralizing antibodies were first detected at 30 days post‐infection, an interference mechanism is postulated as a mechanism of protection of the mice. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company Fil:Scolaro, L.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Mersich, S.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1991 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01466615_v34_n4_p237_Scolaro http://hdl.handle.net/20.500.12110/paper_01466615_v34_n4_p237_Scolaro
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	attenuated mutant mouse strain susceptibility protection neutralizing antibody virus vaccine animal experiment animal model antibody detection article immune response immunization junin virus mouse newborn nonhuman priority journal provocation test virus attenuation virus infection virus mutant Animal Antibodies, Viral Arenaviruses, New World Disease Models, Animal Hemorrhagic Fever, American Kinetics Mice Mice, Inbred Strains Mutation Neutralization Tests Plaque Assay Support, Non-U.S. Gov't Vero Cells Virulence
spellingShingle	attenuated mutant mouse strain susceptibility protection neutralizing antibody virus vaccine animal experiment animal model antibody detection article immune response immunization junin virus mouse newborn nonhuman priority journal provocation test virus attenuation virus infection virus mutant Animal Antibodies, Viral Arenaviruses, New World Disease Models, Animal Hemorrhagic Fever, American Kinetics Mice Mice, Inbred Strains Mutation Neutralization Tests Plaque Assay Support, Non-U.S. Gov't Vero Cells Virulence Scolaro, Luis Alberto Mersich, Susana E. Damonte, Elsa Beatriz Experimental infection of suckling mice with a host range mutant of junin virus
topic_facet	attenuated mutant mouse strain susceptibility protection neutralizing antibody virus vaccine animal experiment animal model antibody detection article immune response immunization junin virus mouse newborn nonhuman priority journal provocation test virus attenuation virus infection virus mutant Animal Antibodies, Viral Arenaviruses, New World Disease Models, Animal Hemorrhagic Fever, American Kinetics Mice Mice, Inbred Strains Mutation Neutralization Tests Plaque Assay Support, Non-U.S. Gov't Vero Cells Virulence
description	Experimental infection of three mouse strains with a non‐pathogenic mutant of Junin virus named C167 was compared with respect to the parental XJC13 strain. After intracerebral (ic) or intraperitoneal inoculation, XJC13 was highly virulent for 2 day‐old C3H/HeJ, OF1, and BALB/cJ mouse strains, whereas its derivative C167 was attenuated. Survival of the C167‐infected mouse was associated with a restricted replication at the site of inoculation which would impair spread of virus. Thus, the reduced virulence of C167 for suckling mice is independent of the mouse strain and the route of viral entry. When C167 was preinoculated ic I0 days before the challenge inoculation with XJC13 by the same route, mice were partially protected from lethal infection. Since neutralizing antibodies were first detected at 30 days post‐infection, an interference mechanism is postulated as a mechanism of protection of the mice. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company
author	Scolaro, Luis Alberto Mersich, Susana E. Damonte, Elsa Beatriz
author_facet	Scolaro, Luis Alberto Mersich, Susana E. Damonte, Elsa Beatriz
author_sort	Scolaro, Luis Alberto
title	Experimental infection of suckling mice with a host range mutant of junin virus
title_short	Experimental infection of suckling mice with a host range mutant of junin virus
title_full	Experimental infection of suckling mice with a host range mutant of junin virus
title_fullStr	Experimental infection of suckling mice with a host range mutant of junin virus
title_full_unstemmed	Experimental infection of suckling mice with a host range mutant of junin virus
title_sort	experimental infection of suckling mice with a host range mutant of junin virus
publishDate	1991
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01466615_v34_n4_p237_Scolaro http://hdl.handle.net/20.500.12110/paper_01466615_v34_n4_p237_Scolaro
work_keys_str_mv	AT scolaroluisalberto experimentalinfectionofsucklingmicewithahostrangemutantofjuninvirus AT mersichsusanae experimentalinfectionofsucklingmicewithahostrangemutantofjuninvirus AT damonteelsabeatriz experimentalinfectionofsucklingmicewithahostrangemutantofjuninvirus
_version_	1768544173786398720

Experimental infection of suckling mice with a host range mutant of junin virus

Ejemplares similares