Hepatic damage and oxidative stress induced by griseofulvin in mice

Erythropoietic Protoporphyria (EPP) is a disease associated with ferrochelatase deficiency, which produces accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver and skin. In some cases, a severe hepatic failure and cholestasis was observed. Griseofulvin (Gris) develops an experimental...

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Detalles Bibliográficos
Autores principales:	Martínez, María del Carmen, Afonso, Susana Graciela, Buzaleh, Ana María, Batlle, Alcira María del Carmen
Publicado:	2009
Materias:	Erythropoietic Protoporphyria Griseofulvin Heme metabolism Liver damage Oxidative stress 5 aminolevulinate synthase alanine aminotransferase alkaline phosphatase aspartate aminotransferase catalase cytochrome P450 1A2 cytochrome P450 2A6 cytochrome P450 2C9 cytochrome P450 2E1 cytochrome P450 3A4 glutathione glutathione peroxidase glutathione reductase glutathione transferase griseofulvin heme heme oxygenase malonaldehyde protoporphyrin reactive oxygen metabolite superoxide dismutase tryptophan 2,3 dioxygenase alanine aminotransferase blood level alkaline phosphatase blood level animal experiment animal model animal tissue antioxidant activity article aspartate aminotransferase blood level blood level body weight controlled study enzyme activity enzyme induction erythropoietic protoporphyria experimental mouse feces level histopathology liver injury liver level liver weight male mouse nonhuman oxidation reduction reaction oxidative stress Animals Antifungal Agents Aryl Hydrocarbon Hydroxylases Cytochrome P-450 CYP3A Disease Models, Animal Heme Heme Oxygenase (Decyclizing) Immunohistochemistry Liver Male Mice Oxidative Stress Protoporphyria, Erythropoietic Protoporphyrins Tryptophan Oxygenase Animalia Mus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01455680_v55_n2_p127_Martinez http://hdl.handle.net/20.500.12110/paper_01455680_v55_n2_p127_Martinez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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