Intermediate metabolism in Trypanosoma cruzi
Epimastigotes of Trypanosoma cruzi, the causative agent of Chagas disease, catabolize proteins and amino acids with production of NH3, and glucose with production of reduced catabolites, chiefly succinate and l-alanine, even under aerobic conditions. This "aerobic fermentation of glucose"...
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1994
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0145479X_v26_n2_p157_Cazzulo http://hdl.handle.net/20.500.12110/paper_0145479X_v26_n2_p157_Cazzulo |
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paper:paper_0145479X_v26_n2_p157_Cazzulo2023-06-08T15:12:17Z Intermediate metabolism in Trypanosoma cruzi aerobic fermentation of glucose aromatic amino acid catabolism cruzipain glutamate dehydrogenases transaminases Trypanosoma cruzi alanine alanine aminotransferase aromatic amino acid cruzipain glutamate dehydrogenase malic acid phosphoenolpyruvate carboxykinase (gtp) pyruvate kinase succinic acid tyrosine aminotransferase amino acid metabolism amino acid transport bacterial metabolism carbohydrate transport glucose metabolism nonhuman protein degradation protein metabolism protein transport respiratory chain review trypanosoma cruzi Aerobiosis Amino Acids Ammonia Animal Biological Transport, Active Carbohydrates Fermentation Glucose Oxidation-Reduction Protozoan Proteins Support, Non-U.S. Gov't Trypanosoma cruzi Epimastigotes of Trypanosoma cruzi, the causative agent of Chagas disease, catabolize proteins and amino acids with production of NH3, and glucose with production of reduced catabolites, chiefly succinate and l-alanine, even under aerobic conditions. This "aerobic fermentation of glucose" is probably due to both the presence of low levels of some cytochromes, causing a relative inefficiency of the respiratory chain for NADH reoxidation during active glucose catabolism, and the lack of NADH dehydrogenase and phosphorylation site I, resulting in the entry of reduction equivalents into the chain mostly as succinate. Phosphoenol pyruvate carboxykinase and pyruvate kinase may play an essential role in diverting glucose carbon to succinate or l-alanine, and l-malate seems to be the major metabolite for the transport of glucose carbon and reduction equivalents between glycosome and mitochondrion. The parasite contains proteinase and peptidase activities. The major lysosomal cysteine proteinase, cruzipain, has been characterized in considerable detail, and might be involved in the host/parasite relationship, in addition to its obvious role in parasite nutrition. Among the enzymes of amino acid catabolism, two glutamate dehydrogenases (one NADP- and the other NAD-linked), alanine aminotransferase, and the major enzymes of aromatic amino acid catabolism (tyrosine aminotransferase and aromatic α-hydroxy acid dehydrogenase), have been characterized and proposed to be involved in the reoxidation of glycolytic NADH. © 1994 Plenum Publishing Corporation. 1994 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0145479X_v26_n2_p157_Cazzulo http://hdl.handle.net/20.500.12110/paper_0145479X_v26_n2_p157_Cazzulo |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
aerobic fermentation of glucose aromatic amino acid catabolism cruzipain glutamate dehydrogenases transaminases Trypanosoma cruzi alanine alanine aminotransferase aromatic amino acid cruzipain glutamate dehydrogenase malic acid phosphoenolpyruvate carboxykinase (gtp) pyruvate kinase succinic acid tyrosine aminotransferase amino acid metabolism amino acid transport bacterial metabolism carbohydrate transport glucose metabolism nonhuman protein degradation protein metabolism protein transport respiratory chain review trypanosoma cruzi Aerobiosis Amino Acids Ammonia Animal Biological Transport, Active Carbohydrates Fermentation Glucose Oxidation-Reduction Protozoan Proteins Support, Non-U.S. Gov't Trypanosoma cruzi |
| spellingShingle |
aerobic fermentation of glucose aromatic amino acid catabolism cruzipain glutamate dehydrogenases transaminases Trypanosoma cruzi alanine alanine aminotransferase aromatic amino acid cruzipain glutamate dehydrogenase malic acid phosphoenolpyruvate carboxykinase (gtp) pyruvate kinase succinic acid tyrosine aminotransferase amino acid metabolism amino acid transport bacterial metabolism carbohydrate transport glucose metabolism nonhuman protein degradation protein metabolism protein transport respiratory chain review trypanosoma cruzi Aerobiosis Amino Acids Ammonia Animal Biological Transport, Active Carbohydrates Fermentation Glucose Oxidation-Reduction Protozoan Proteins Support, Non-U.S. Gov't Trypanosoma cruzi Intermediate metabolism in Trypanosoma cruzi |
| topic_facet |
aerobic fermentation of glucose aromatic amino acid catabolism cruzipain glutamate dehydrogenases transaminases Trypanosoma cruzi alanine alanine aminotransferase aromatic amino acid cruzipain glutamate dehydrogenase malic acid phosphoenolpyruvate carboxykinase (gtp) pyruvate kinase succinic acid tyrosine aminotransferase amino acid metabolism amino acid transport bacterial metabolism carbohydrate transport glucose metabolism nonhuman protein degradation protein metabolism protein transport respiratory chain review trypanosoma cruzi Aerobiosis Amino Acids Ammonia Animal Biological Transport, Active Carbohydrates Fermentation Glucose Oxidation-Reduction Protozoan Proteins Support, Non-U.S. Gov't Trypanosoma cruzi |
| description |
Epimastigotes of Trypanosoma cruzi, the causative agent of Chagas disease, catabolize proteins and amino acids with production of NH3, and glucose with production of reduced catabolites, chiefly succinate and l-alanine, even under aerobic conditions. This "aerobic fermentation of glucose" is probably due to both the presence of low levels of some cytochromes, causing a relative inefficiency of the respiratory chain for NADH reoxidation during active glucose catabolism, and the lack of NADH dehydrogenase and phosphorylation site I, resulting in the entry of reduction equivalents into the chain mostly as succinate. Phosphoenol pyruvate carboxykinase and pyruvate kinase may play an essential role in diverting glucose carbon to succinate or l-alanine, and l-malate seems to be the major metabolite for the transport of glucose carbon and reduction equivalents between glycosome and mitochondrion. The parasite contains proteinase and peptidase activities. The major lysosomal cysteine proteinase, cruzipain, has been characterized in considerable detail, and might be involved in the host/parasite relationship, in addition to its obvious role in parasite nutrition. Among the enzymes of amino acid catabolism, two glutamate dehydrogenases (one NADP- and the other NAD-linked), alanine aminotransferase, and the major enzymes of aromatic amino acid catabolism (tyrosine aminotransferase and aromatic α-hydroxy acid dehydrogenase), have been characterized and proposed to be involved in the reoxidation of glycolytic NADH. © 1994 Plenum Publishing Corporation. |
| title |
Intermediate metabolism in Trypanosoma cruzi |
| title_short |
Intermediate metabolism in Trypanosoma cruzi |
| title_full |
Intermediate metabolism in Trypanosoma cruzi |
| title_fullStr |
Intermediate metabolism in Trypanosoma cruzi |
| title_full_unstemmed |
Intermediate metabolism in Trypanosoma cruzi |
| title_sort |
intermediate metabolism in trypanosoma cruzi |
| publishDate |
1994 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0145479X_v26_n2_p157_Cazzulo http://hdl.handle.net/20.500.12110/paper_0145479X_v26_n2_p157_Cazzulo |
| _version_ |
1768545044121255936 |