Microwave-assisted desulfation of sulfated polysaccharides

Several sulfated polysaccharides were desulfated by heating their pyridinium salts dissolved in dimethyl sulfoxide in a microwave oven. The procedure was applied to different products like a λ-carrageenan, a partially cyclized μ/ν-carrageenan, an agar-like product like corallinan, a fucoidan and a c...

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Autores principales:	Navarro, Diego Alberto, Stortz, Carlos Arturo
Publicado:	2007
Materias:	Agaran Carrageenan Chondroitin Desulfation Fucoidan Microwave irradiation Depolymerization Heating Microwave ovens Salts Spectroscopic analysis Sulfate minerals Polysaccharides
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01448617_v69_n4_p742_Navarro http://hdl.handle.net/20.500.12110/paper_01448617_v69_n4_p742_Navarro
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01448617_v69_n4_p742_Navarro
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spelling	paper:paper_01448617_v69_n4_p742_Navarro2023-06-08T15:12:10Z Microwave-assisted desulfation of sulfated polysaccharides Navarro, Diego Alberto Stortz, Carlos Arturo Agaran Carrageenan Chondroitin Desulfation Fucoidan Microwave irradiation Depolymerization Heating Microwave irradiation Microwave ovens Salts Spectroscopic analysis Sulfate minerals Agaran Carrageenan Desulfation Fucoidan Polysaccharides Several sulfated polysaccharides were desulfated by heating their pyridinium salts dissolved in dimethyl sulfoxide in a microwave oven. The procedure was applied to different products like a λ-carrageenan, a partially cyclized μ/ν-carrageenan, an agar-like product like corallinan, a fucoidan and a chondroitin sulfate. When their pyridinium salts were generated in carefully chosen conditions, the desulfation proceeds smoothly after 1 min of heating, leading to a removal of 60-93% of the original sulfate present. Some depolymerization was found to occur, but its effect is moderate (yields of the recovered products are 64-89%), even for polysaccharides with labile bonds. An in situ methylation procedure was coupled with the microwave-aided desulfation method in order to facilitate the retrieval of structural data. Both spectroscopical and chemical studies showed that the integrity of the polysaccharides was not affected by this procedure (besides the loss of sulfate and the above-mentioned depolymerization). © 2007 Elsevier Ltd. All rights reserved. Fil:Navarro, D.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Stortz, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01448617_v69_n4_p742_Navarro http://hdl.handle.net/20.500.12110/paper_01448617_v69_n4_p742_Navarro
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Agaran Carrageenan Chondroitin Desulfation Fucoidan Microwave irradiation Depolymerization Heating Microwave irradiation Microwave ovens Salts Spectroscopic analysis Sulfate minerals Agaran Carrageenan Desulfation Fucoidan Polysaccharides
spellingShingle	Agaran Carrageenan Chondroitin Desulfation Fucoidan Microwave irradiation Depolymerization Heating Microwave irradiation Microwave ovens Salts Spectroscopic analysis Sulfate minerals Agaran Carrageenan Desulfation Fucoidan Polysaccharides Navarro, Diego Alberto Stortz, Carlos Arturo Microwave-assisted desulfation of sulfated polysaccharides
topic_facet	Agaran Carrageenan Chondroitin Desulfation Fucoidan Microwave irradiation Depolymerization Heating Microwave irradiation Microwave ovens Salts Spectroscopic analysis Sulfate minerals Agaran Carrageenan Desulfation Fucoidan Polysaccharides
description	Several sulfated polysaccharides were desulfated by heating their pyridinium salts dissolved in dimethyl sulfoxide in a microwave oven. The procedure was applied to different products like a λ-carrageenan, a partially cyclized μ/ν-carrageenan, an agar-like product like corallinan, a fucoidan and a chondroitin sulfate. When their pyridinium salts were generated in carefully chosen conditions, the desulfation proceeds smoothly after 1 min of heating, leading to a removal of 60-93% of the original sulfate present. Some depolymerization was found to occur, but its effect is moderate (yields of the recovered products are 64-89%), even for polysaccharides with labile bonds. An in situ methylation procedure was coupled with the microwave-aided desulfation method in order to facilitate the retrieval of structural data. Both spectroscopical and chemical studies showed that the integrity of the polysaccharides was not affected by this procedure (besides the loss of sulfate and the above-mentioned depolymerization). © 2007 Elsevier Ltd. All rights reserved.
author	Navarro, Diego Alberto Stortz, Carlos Arturo
author_facet	Navarro, Diego Alberto Stortz, Carlos Arturo
author_sort	Navarro, Diego Alberto
title	Microwave-assisted desulfation of sulfated polysaccharides
title_short	Microwave-assisted desulfation of sulfated polysaccharides
title_full	Microwave-assisted desulfation of sulfated polysaccharides
title_fullStr	Microwave-assisted desulfation of sulfated polysaccharides
title_full_unstemmed	Microwave-assisted desulfation of sulfated polysaccharides
title_sort	microwave-assisted desulfation of sulfated polysaccharides
publishDate	2007
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01448617_v69_n4_p742_Navarro http://hdl.handle.net/20.500.12110/paper_01448617_v69_n4_p742_Navarro
work_keys_str_mv	AT navarrodiegoalberto microwaveassisteddesulfationofsulfatedpolysaccharides AT stortzcarlosarturo microwaveassisteddesulfationofsulfatedpolysaccharides
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Microwave-assisted desulfation of sulfated polysaccharides

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