Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus
Chemical and spectroscopic methods showed that the major KCl-precipitated galactans from Meristiella gelidium (Solieriaceae) are iota/kappa/nu-hybrid carrageenans with the former one in higher proportion. These carrageenans showed, by HPSEC-MALLS analysis, unimodal symmetrical peaks with MW of 425.6...
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2006
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01448617_v63_n4_p459_DeSfTischer http://hdl.handle.net/20.500.12110/paper_01448617_v63_n4_p459_DeSfTischer |
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paper:paper_01448617_v63_n4_p459_DeSfTischer2023-06-08T15:12:09Z Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus Antiviral activity Chemical structure Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Molecular structure Polysaccharides Potassium compounds Spectroscopy Antiviral activity Chemical structures Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Viruses algae Dengue virus Herpes Human herpesvirus 2 Meristiella gelidium Simplexvirus Solieriaceae Chemical and spectroscopic methods showed that the major KCl-precipitated galactans from Meristiella gelidium (Solieriaceae) are iota/kappa/nu-hybrid carrageenans with the former one in higher proportion. These carrageenans showed, by HPSEC-MALLS analysis, unimodal symmetrical peaks with MW of 425.6-956.7 kDa. The effectiveness of the crude extracts from M. gelidium against HSV-2 was higher than the corresponding extract from G. griffithsiae, previously determined. However, when considering the homogeneous carrageenans, the fractions obtained from both seaweeds showed the same level of activity. The extracts and carrageenan derived from M. gelidium were more effective inhibitors of DENV-2 if compared with G. griffithsiae samples and reference polysaccharides. The most active fraction obtained from M. gelidium showed a selectivity index against HSV-2 of 25,000, a value high enough to consider this carrageenan as a promising agent to be evaluated for the treatment of genital HSV-2 infections. © 2005 Elsevier Ltd. All rights reserved. 2006 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01448617_v63_n4_p459_DeSfTischer http://hdl.handle.net/20.500.12110/paper_01448617_v63_n4_p459_DeSfTischer |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Antiviral activity Chemical structure Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Molecular structure Polysaccharides Potassium compounds Spectroscopy Antiviral activity Chemical structures Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Viruses algae Dengue virus Herpes Human herpesvirus 2 Meristiella gelidium Simplexvirus Solieriaceae |
| spellingShingle |
Antiviral activity Chemical structure Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Molecular structure Polysaccharides Potassium compounds Spectroscopy Antiviral activity Chemical structures Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Viruses algae Dengue virus Herpes Human herpesvirus 2 Meristiella gelidium Simplexvirus Solieriaceae Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus |
| topic_facet |
Antiviral activity Chemical structure Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Molecular structure Polysaccharides Potassium compounds Spectroscopy Antiviral activity Chemical structures Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Viruses algae Dengue virus Herpes Human herpesvirus 2 Meristiella gelidium Simplexvirus Solieriaceae |
| description |
Chemical and spectroscopic methods showed that the major KCl-precipitated galactans from Meristiella gelidium (Solieriaceae) are iota/kappa/nu-hybrid carrageenans with the former one in higher proportion. These carrageenans showed, by HPSEC-MALLS analysis, unimodal symmetrical peaks with MW of 425.6-956.7 kDa. The effectiveness of the crude extracts from M. gelidium against HSV-2 was higher than the corresponding extract from G. griffithsiae, previously determined. However, when considering the homogeneous carrageenans, the fractions obtained from both seaweeds showed the same level of activity. The extracts and carrageenan derived from M. gelidium were more effective inhibitors of DENV-2 if compared with G. griffithsiae samples and reference polysaccharides. The most active fraction obtained from M. gelidium showed a selectivity index against HSV-2 of 25,000, a value high enough to consider this carrageenan as a promising agent to be evaluated for the treatment of genital HSV-2 infections. © 2005 Elsevier Ltd. All rights reserved. |
| title |
Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus |
| title_short |
Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus |
| title_full |
Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus |
| title_fullStr |
Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus |
| title_full_unstemmed |
Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus |
| title_sort |
chemical structure and antiviral activity of carrageenans from meristiella gelidium against herpes simplex and dengue virus |
| publishDate |
2006 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01448617_v63_n4_p459_DeSfTischer http://hdl.handle.net/20.500.12110/paper_01448617_v63_n4_p459_DeSfTischer |
| _version_ |
1768543651889152000 |