Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice
The promoter effect of medroxyprogesterone acetate (MPA) on mammary carcinogenesis in female BALB/c mice was investigated using methylnitrosourea (MNU) as initiator. Nine out of 43 animals developed mammary carcinomas in the group treated with MNU (50 mg/kg) and MPA (administration of 40 mg every 3...
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1998
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01433334_v19_n3_p529_Pazos http://hdl.handle.net/20.500.12110/paper_01433334_v19_n3_p529_Pazos |
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paper:paper_01433334_v19_n3_p529_Pazos2023-06-08T15:11:48Z Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice estrogen receptor medroxyprogesterone acetate methylnitrosourea progesterone receptor animal experiment animal model animal tissue article breast adenocarcinoma breast carcinogenesis breast tumor cell differentiation controlled study female mouse nonhuman priority journal promoter region Adenocarcinoma Animals Carcinogens Cocarcinogenesis Female Mammary Neoplasms, Experimental Medroxyprogesterone 17-Acetate Methylnitrosourea Mice Mice, Inbred BALB C The promoter effect of medroxyprogesterone acetate (MPA) on mammary carcinogenesis in female BALB/c mice was investigated using methylnitrosourea (MNU) as initiator. Nine out of 43 animals developed mammary carcinomas in the group treated with MNU (50 mg/kg) and MPA (administration of 40 mg every 3 months) starting 1 week after MNU administration. No tumors appeared in controls receiving only MNU or MPA during the time course of the experiment (9 months). The tumors were lobular adenocarcinomas showing different degrees of squamous differentiation with low or undetectable estrogen and progesterone receptors, and expressing epidermal growth factor receptors. These results support the hypothesis that MPA promotes the growth of MNU induced lesions. 1998 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01433334_v19_n3_p529_Pazos http://hdl.handle.net/20.500.12110/paper_01433334_v19_n3_p529_Pazos |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
estrogen receptor medroxyprogesterone acetate methylnitrosourea progesterone receptor animal experiment animal model animal tissue article breast adenocarcinoma breast carcinogenesis breast tumor cell differentiation controlled study female mouse nonhuman priority journal promoter region Adenocarcinoma Animals Carcinogens Cocarcinogenesis Female Mammary Neoplasms, Experimental Medroxyprogesterone 17-Acetate Methylnitrosourea Mice Mice, Inbred BALB C |
| spellingShingle |
estrogen receptor medroxyprogesterone acetate methylnitrosourea progesterone receptor animal experiment animal model animal tissue article breast adenocarcinoma breast carcinogenesis breast tumor cell differentiation controlled study female mouse nonhuman priority journal promoter region Adenocarcinoma Animals Carcinogens Cocarcinogenesis Female Mammary Neoplasms, Experimental Medroxyprogesterone 17-Acetate Methylnitrosourea Mice Mice, Inbred BALB C Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice |
| topic_facet |
estrogen receptor medroxyprogesterone acetate methylnitrosourea progesterone receptor animal experiment animal model animal tissue article breast adenocarcinoma breast carcinogenesis breast tumor cell differentiation controlled study female mouse nonhuman priority journal promoter region Adenocarcinoma Animals Carcinogens Cocarcinogenesis Female Mammary Neoplasms, Experimental Medroxyprogesterone 17-Acetate Methylnitrosourea Mice Mice, Inbred BALB C |
| description |
The promoter effect of medroxyprogesterone acetate (MPA) on mammary carcinogenesis in female BALB/c mice was investigated using methylnitrosourea (MNU) as initiator. Nine out of 43 animals developed mammary carcinomas in the group treated with MNU (50 mg/kg) and MPA (administration of 40 mg every 3 months) starting 1 week after MNU administration. No tumors appeared in controls receiving only MNU or MPA during the time course of the experiment (9 months). The tumors were lobular adenocarcinomas showing different degrees of squamous differentiation with low or undetectable estrogen and progesterone receptors, and expressing epidermal growth factor receptors. These results support the hypothesis that MPA promotes the growth of MNU induced lesions. |
| title |
Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice |
| title_short |
Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice |
| title_full |
Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice |
| title_fullStr |
Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice |
| title_full_unstemmed |
Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice |
| title_sort |
promoter effect of medroxyprogesterone acetate (mpa) in n-methyl-n-nitrosourea (mnu) induced mammary tumors in balb/c mice |
| publishDate |
1998 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01433334_v19_n3_p529_Pazos http://hdl.handle.net/20.500.12110/paper_01433334_v19_n3_p529_Pazos |
| _version_ |
1768546578028560384 |