The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates
Herpes simplex virus belongs to Herpesviridae family and causes infection of humans from ancient times. 4OMe-glucuronoxylans as the renewable biopolymers can be promising glycomaterials for various applications in pharmacy. Control enzymatic degradation of the native 4OMe-glucuronoxylan (GX1) follow...
| Autores principales: | , |
|---|---|
| Publicado: |
2016
|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01418130_v87_n_p195_Pujol http://hdl.handle.net/20.500.12110/paper_01418130_v87_n_p195_Pujol |
| Aporte de: |
| id |
paper:paper_01418130_v87_n_p195_Pujol |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_01418130_v87_n_p195_Pujol2023-06-08T15:11:26Z The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates Pujol, Carlos Alberto Damonte, Elsa Beatriz 4OMe-glucuronoxylan sulfates Antiviral activity Herpes simplex virus 4 o methylglucuronoxylan sulfate antivirus agent arabinose dextran sulfate galactose glucose glucuronic acid heparin unclassified drug antivirus agent glucuronoxylan sulfate xylan animal cell antiviral activity Article cytotoxic concentration Dengue virus 2 drug effect drug potency drug sulfation enzymatic degradation Fagus sylvatica Herpes simplex virus 1 Herpes simplex virus 2 Human poliovirus 1 inhibitory concentration molecular weight nonhuman selectivity index virus inhibition animal beech chemistry Chlorocebus aethiops drug effects Vero cell line virus Animals Antiviral Agents Cercopithecus aethiops Fagus Sulfates Vero Cells Viruses Xylans Herpes simplex virus belongs to Herpesviridae family and causes infection of humans from ancient times. 4OMe-glucuronoxylans as the renewable biopolymers can be promising glycomaterials for various applications in pharmacy. Control enzymatic degradation of the native 4OMe-glucuronoxylan (GX1) followed by targeted sulfation procedure afforded a range of 4OMe-glucuronoxylan sulfates differed in the degree of sulfation (10-16%) and molecular mass (21,000-5000 g/mol; GXS1 > GXS2 > GXS3 > GXS4). Antiviral activity tests on GXS1-4 against herpes simplex virus (HSV) types 1 and 2 revealed the positive effect of all compounds against strains of herpes virus. Of them, the compounds GXS1 and GXS4 were shown to be the most active for both HSV serotypes. The antiviral activity of GXS1 and GXS4 was similar to those of heparin or dextran sulfate, used as reference compounds. It was found that GXS1 and GXS4 were active as well against Polio and dengue viruses, however, on a smaller scale. The mode of antiviral action of 4OMe-glucuronoxylan sulfates is due to inhibition of the virus binding to the cell receptors. © 2016 Elsevier B.V. Fil:Pujol, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01418130_v87_n_p195_Pujol http://hdl.handle.net/20.500.12110/paper_01418130_v87_n_p195_Pujol |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
4OMe-glucuronoxylan sulfates Antiviral activity Herpes simplex virus 4 o methylglucuronoxylan sulfate antivirus agent arabinose dextran sulfate galactose glucose glucuronic acid heparin unclassified drug antivirus agent glucuronoxylan sulfate xylan animal cell antiviral activity Article cytotoxic concentration Dengue virus 2 drug effect drug potency drug sulfation enzymatic degradation Fagus sylvatica Herpes simplex virus 1 Herpes simplex virus 2 Human poliovirus 1 inhibitory concentration molecular weight nonhuman selectivity index virus inhibition animal beech chemistry Chlorocebus aethiops drug effects Vero cell line virus Animals Antiviral Agents Cercopithecus aethiops Fagus Sulfates Vero Cells Viruses Xylans |
| spellingShingle |
4OMe-glucuronoxylan sulfates Antiviral activity Herpes simplex virus 4 o methylglucuronoxylan sulfate antivirus agent arabinose dextran sulfate galactose glucose glucuronic acid heparin unclassified drug antivirus agent glucuronoxylan sulfate xylan animal cell antiviral activity Article cytotoxic concentration Dengue virus 2 drug effect drug potency drug sulfation enzymatic degradation Fagus sylvatica Herpes simplex virus 1 Herpes simplex virus 2 Human poliovirus 1 inhibitory concentration molecular weight nonhuman selectivity index virus inhibition animal beech chemistry Chlorocebus aethiops drug effects Vero cell line virus Animals Antiviral Agents Cercopithecus aethiops Fagus Sulfates Vero Cells Viruses Xylans Pujol, Carlos Alberto Damonte, Elsa Beatriz The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates |
| topic_facet |
4OMe-glucuronoxylan sulfates Antiviral activity Herpes simplex virus 4 o methylglucuronoxylan sulfate antivirus agent arabinose dextran sulfate galactose glucose glucuronic acid heparin unclassified drug antivirus agent glucuronoxylan sulfate xylan animal cell antiviral activity Article cytotoxic concentration Dengue virus 2 drug effect drug potency drug sulfation enzymatic degradation Fagus sylvatica Herpes simplex virus 1 Herpes simplex virus 2 Human poliovirus 1 inhibitory concentration molecular weight nonhuman selectivity index virus inhibition animal beech chemistry Chlorocebus aethiops drug effects Vero cell line virus Animals Antiviral Agents Cercopithecus aethiops Fagus Sulfates Vero Cells Viruses Xylans |
| description |
Herpes simplex virus belongs to Herpesviridae family and causes infection of humans from ancient times. 4OMe-glucuronoxylans as the renewable biopolymers can be promising glycomaterials for various applications in pharmacy. Control enzymatic degradation of the native 4OMe-glucuronoxylan (GX1) followed by targeted sulfation procedure afforded a range of 4OMe-glucuronoxylan sulfates differed in the degree of sulfation (10-16%) and molecular mass (21,000-5000 g/mol; GXS1 > GXS2 > GXS3 > GXS4). Antiviral activity tests on GXS1-4 against herpes simplex virus (HSV) types 1 and 2 revealed the positive effect of all compounds against strains of herpes virus. Of them, the compounds GXS1 and GXS4 were shown to be the most active for both HSV serotypes. The antiviral activity of GXS1 and GXS4 was similar to those of heparin or dextran sulfate, used as reference compounds. It was found that GXS1 and GXS4 were active as well against Polio and dengue viruses, however, on a smaller scale. The mode of antiviral action of 4OMe-glucuronoxylan sulfates is due to inhibition of the virus binding to the cell receptors. © 2016 Elsevier B.V. |
| author |
Pujol, Carlos Alberto Damonte, Elsa Beatriz |
| author_facet |
Pujol, Carlos Alberto Damonte, Elsa Beatriz |
| author_sort |
Pujol, Carlos Alberto |
| title |
The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates |
| title_short |
The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates |
| title_full |
The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates |
| title_fullStr |
The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates |
| title_full_unstemmed |
The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates |
| title_sort |
antiviral potency of fagus sylvatica 4ome-glucuronoxylan sulfates |
| publishDate |
2016 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01418130_v87_n_p195_Pujol http://hdl.handle.net/20.500.12110/paper_01418130_v87_n_p195_Pujol |
| work_keys_str_mv |
AT pujolcarlosalberto theantiviralpotencyoffagussylvatica4omeglucuronoxylansulfates AT damonteelsabeatriz theantiviralpotencyoffagussylvatica4omeglucuronoxylansulfates AT pujolcarlosalberto antiviralpotencyoffagussylvatica4omeglucuronoxylansulfates AT damonteelsabeatriz antiviralpotencyoffagussylvatica4omeglucuronoxylansulfates |
| _version_ |
1768543127951376384 |