Screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides
Modified nucleosides can be prepared by microbial transglycosylation from cheaper nucleoside precursors using free or immobilised whole cells. An efficient screening method to find transglycosylation activity in microorganisms was developed for the synthesis of 6-modified purine nucleosides, such as...
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2005
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01415492_v27_n11_p759_Trelles http://hdl.handle.net/20.500.12110/paper_01415492_v27_n11_p759_Trelles |
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paper:paper_01415492_v27_n11_p759_Trelles2023-06-08T15:11:20Z Screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides Bacillus stearothermophilus Microbial transglycosylation Nucleoside phosphorylases Nucleosides Screening Biosynthesis Catalysis Cells Enzymes Screening Bacillus stearothermophiles Microbial transglycosylation Nucleoside phosphorylases Nucleosides Microorganisms nucleoside purine nucleoside purine nucleoside phosphorylase article bacterium biosynthesis catalysis economics enzymology Geobacillus stearothermophilus glycosylation isolation and purification metabolism methodology microbiology Bacillus stearothermophilus Bacteria Catalysis Glycosylation Industrial Microbiology Nucleosides Purine Nucleosides Purine-Nucleoside Phosphorylase Geobacillus stearothermophilus Modified nucleosides can be prepared by microbial transglycosylation from cheaper nucleoside precursors using free or immobilised whole cells. An efficient screening method to find transglycosylation activity in microorganisms was developed for the synthesis of 6-modified purine nucleosides, such as 6-chloro-, 6-methoxy-, 6-iodo- and 6-mercaptopurine ribonucleoside. Out of 100 microorganisms screened, Bacillus stearothermophilus ATCC 12980 was the best for this purpose. © Springer 2005. 2005 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01415492_v27_n11_p759_Trelles http://hdl.handle.net/20.500.12110/paper_01415492_v27_n11_p759_Trelles |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Bacillus stearothermophilus Microbial transglycosylation Nucleoside phosphorylases Nucleosides Screening Biosynthesis Catalysis Cells Enzymes Screening Bacillus stearothermophiles Microbial transglycosylation Nucleoside phosphorylases Nucleosides Microorganisms nucleoside purine nucleoside purine nucleoside phosphorylase article bacterium biosynthesis catalysis economics enzymology Geobacillus stearothermophilus glycosylation isolation and purification metabolism methodology microbiology Bacillus stearothermophilus Bacteria Catalysis Glycosylation Industrial Microbiology Nucleosides Purine Nucleosides Purine-Nucleoside Phosphorylase Geobacillus stearothermophilus |
| spellingShingle |
Bacillus stearothermophilus Microbial transglycosylation Nucleoside phosphorylases Nucleosides Screening Biosynthesis Catalysis Cells Enzymes Screening Bacillus stearothermophiles Microbial transglycosylation Nucleoside phosphorylases Nucleosides Microorganisms nucleoside purine nucleoside purine nucleoside phosphorylase article bacterium biosynthesis catalysis economics enzymology Geobacillus stearothermophilus glycosylation isolation and purification metabolism methodology microbiology Bacillus stearothermophilus Bacteria Catalysis Glycosylation Industrial Microbiology Nucleosides Purine Nucleosides Purine-Nucleoside Phosphorylase Geobacillus stearothermophilus Screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides |
| topic_facet |
Bacillus stearothermophilus Microbial transglycosylation Nucleoside phosphorylases Nucleosides Screening Biosynthesis Catalysis Cells Enzymes Screening Bacillus stearothermophiles Microbial transglycosylation Nucleoside phosphorylases Nucleosides Microorganisms nucleoside purine nucleoside purine nucleoside phosphorylase article bacterium biosynthesis catalysis economics enzymology Geobacillus stearothermophilus glycosylation isolation and purification metabolism methodology microbiology Bacillus stearothermophilus Bacteria Catalysis Glycosylation Industrial Microbiology Nucleosides Purine Nucleosides Purine-Nucleoside Phosphorylase Geobacillus stearothermophilus |
| description |
Modified nucleosides can be prepared by microbial transglycosylation from cheaper nucleoside precursors using free or immobilised whole cells. An efficient screening method to find transglycosylation activity in microorganisms was developed for the synthesis of 6-modified purine nucleosides, such as 6-chloro-, 6-methoxy-, 6-iodo- and 6-mercaptopurine ribonucleoside. Out of 100 microorganisms screened, Bacillus stearothermophilus ATCC 12980 was the best for this purpose. © Springer 2005. |
| title |
Screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides |
| title_short |
Screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides |
| title_full |
Screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides |
| title_fullStr |
Screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides |
| title_full_unstemmed |
Screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides |
| title_sort |
screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides |
| publishDate |
2005 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01415492_v27_n11_p759_Trelles http://hdl.handle.net/20.500.12110/paper_01415492_v27_n11_p759_Trelles |
| _version_ |
1768545368010653696 |