Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments
The immune system has evolved sophisticated mechanisms composed of several checkpoints and fail-safe processes that enable it to orchestrate innate and adaptive immunity, while at the same time limiting aberrant or unfaithful T-cell function. These multiple regulatory pathways take place during the...
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01052896_v230_n1_p144_Rabinovich http://hdl.handle.net/20.500.12110/paper_01052896_v230_n1_p144_Rabinovich |
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paper:paper_01052896_v230_n1_p144_Rabinovich2023-06-08T15:10:32Z Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments Ilarregui, Juan Martín Autoimmunity Galectin-1 Glycosylation Inflammation Tolerance Tumor-immune escape carbohydrate cell surface protein cytokine galectin 1 glycan ligand T lymphocyte receptor adaptive immunity apoptosis autoimmune disease autoimmunity CD25+ T lymphocyte CD4+ T lymphocyte cell activation cell differentiation cell function cell homing cell migration cell survival chronic inflammation cytokine release homeostasis human immune response immune system immunoregulation inflammation innate immunity macrophage monocyte neoplasm nonhuman pregnancy priority journal protein binding protein carbohydrate interaction protein expression protein function regulatory T lymphocyte review signal transduction T lymphocyte Th1 cell Th2 cell tumor tumor growth Animals Cell Adhesion Cell Movement Cell Survival Cytokines Galectin 1 Homeostasis Humans Inflammation Lymphocyte Activation Neoplasms Polysaccharides Signal Transduction T-Lymphocyte Subsets The immune system has evolved sophisticated mechanisms composed of several checkpoints and fail-safe processes that enable it to orchestrate innate and adaptive immunity, while at the same time limiting aberrant or unfaithful T-cell function. These multiple regulatory pathways take place during the entire life-span of T cells including T-cell development, homing, activation, and differentiation. Galectin-1, an endogenous glycan-binding protein widely expressed at sites of inflammation and tumor growth, controls a diversity of immune cell processes, acting either extracellularly through specific binding to cell surface glycan structures or intracellularly through modulation of pathways that remain largely unexplored. In this review, we highlight the discoveries that have led to our current understanding of the role of galectin-1 in distinct immune cell process, particularly those associated with T-cell homeostasis. Also, we emphasize findings emerging from the study of experimental models of autoimmunity, chronic inflammation, fetomaternal tolerance, and tumor growth, which have provided fundamental insights into the critical role of galectin-1 and its specific saccharide ligands in immunoregulation. Challenges for the future will embrace the rational manipulation of galectin-1-glycan interactions both towards attenuating immune responses in autoimmune diseases, graft rejection, and recurrent fetal loss, while at the same overcoming immune tolerance in chronic infections and cancer. © 2009 John Wiley & Sons A/S. Fil:Ilarregui, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01052896_v230_n1_p144_Rabinovich http://hdl.handle.net/20.500.12110/paper_01052896_v230_n1_p144_Rabinovich |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Autoimmunity Galectin-1 Glycosylation Inflammation Tolerance Tumor-immune escape carbohydrate cell surface protein cytokine galectin 1 glycan ligand T lymphocyte receptor adaptive immunity apoptosis autoimmune disease autoimmunity CD25+ T lymphocyte CD4+ T lymphocyte cell activation cell differentiation cell function cell homing cell migration cell survival chronic inflammation cytokine release homeostasis human immune response immune system immunoregulation inflammation innate immunity macrophage monocyte neoplasm nonhuman pregnancy priority journal protein binding protein carbohydrate interaction protein expression protein function regulatory T lymphocyte review signal transduction T lymphocyte Th1 cell Th2 cell tumor tumor growth Animals Cell Adhesion Cell Movement Cell Survival Cytokines Galectin 1 Homeostasis Humans Inflammation Lymphocyte Activation Neoplasms Polysaccharides Signal Transduction T-Lymphocyte Subsets |
| spellingShingle |
Autoimmunity Galectin-1 Glycosylation Inflammation Tolerance Tumor-immune escape carbohydrate cell surface protein cytokine galectin 1 glycan ligand T lymphocyte receptor adaptive immunity apoptosis autoimmune disease autoimmunity CD25+ T lymphocyte CD4+ T lymphocyte cell activation cell differentiation cell function cell homing cell migration cell survival chronic inflammation cytokine release homeostasis human immune response immune system immunoregulation inflammation innate immunity macrophage monocyte neoplasm nonhuman pregnancy priority journal protein binding protein carbohydrate interaction protein expression protein function regulatory T lymphocyte review signal transduction T lymphocyte Th1 cell Th2 cell tumor tumor growth Animals Cell Adhesion Cell Movement Cell Survival Cytokines Galectin 1 Homeostasis Humans Inflammation Lymphocyte Activation Neoplasms Polysaccharides Signal Transduction T-Lymphocyte Subsets Ilarregui, Juan Martín Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments |
| topic_facet |
Autoimmunity Galectin-1 Glycosylation Inflammation Tolerance Tumor-immune escape carbohydrate cell surface protein cytokine galectin 1 glycan ligand T lymphocyte receptor adaptive immunity apoptosis autoimmune disease autoimmunity CD25+ T lymphocyte CD4+ T lymphocyte cell activation cell differentiation cell function cell homing cell migration cell survival chronic inflammation cytokine release homeostasis human immune response immune system immunoregulation inflammation innate immunity macrophage monocyte neoplasm nonhuman pregnancy priority journal protein binding protein carbohydrate interaction protein expression protein function regulatory T lymphocyte review signal transduction T lymphocyte Th1 cell Th2 cell tumor tumor growth Animals Cell Adhesion Cell Movement Cell Survival Cytokines Galectin 1 Homeostasis Humans Inflammation Lymphocyte Activation Neoplasms Polysaccharides Signal Transduction T-Lymphocyte Subsets |
| description |
The immune system has evolved sophisticated mechanisms composed of several checkpoints and fail-safe processes that enable it to orchestrate innate and adaptive immunity, while at the same time limiting aberrant or unfaithful T-cell function. These multiple regulatory pathways take place during the entire life-span of T cells including T-cell development, homing, activation, and differentiation. Galectin-1, an endogenous glycan-binding protein widely expressed at sites of inflammation and tumor growth, controls a diversity of immune cell processes, acting either extracellularly through specific binding to cell surface glycan structures or intracellularly through modulation of pathways that remain largely unexplored. In this review, we highlight the discoveries that have led to our current understanding of the role of galectin-1 in distinct immune cell process, particularly those associated with T-cell homeostasis. Also, we emphasize findings emerging from the study of experimental models of autoimmunity, chronic inflammation, fetomaternal tolerance, and tumor growth, which have provided fundamental insights into the critical role of galectin-1 and its specific saccharide ligands in immunoregulation. Challenges for the future will embrace the rational manipulation of galectin-1-glycan interactions both towards attenuating immune responses in autoimmune diseases, graft rejection, and recurrent fetal loss, while at the same overcoming immune tolerance in chronic infections and cancer. © 2009 John Wiley & Sons A/S. |
| author |
Ilarregui, Juan Martín |
| author_facet |
Ilarregui, Juan Martín |
| author_sort |
Ilarregui, Juan Martín |
| title |
Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments |
| title_short |
Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments |
| title_full |
Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments |
| title_fullStr |
Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments |
| title_full_unstemmed |
Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments |
| title_sort |
conveying glycan information into t-cell homeostatic programs: a challenging role for galectin-1 in inflammatory and tumor microenvironments |
| publishDate |
2009 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01052896_v230_n1_p144_Rabinovich http://hdl.handle.net/20.500.12110/paper_01052896_v230_n1_p144_Rabinovich |
| work_keys_str_mv |
AT ilarreguijuanmartin conveyingglycaninformationintotcellhomeostaticprogramsachallengingroleforgalectin1ininflammatoryandtumormicroenvironments |
| _version_ |
1768544079295021056 |