Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory

A decade of studies on long-term habituation (LTH) in the crab Chasmagnathus is reviewed. Upon sudden presentation of a passing object overhead, the crab reacts with an escape response that habituates promptly and for at least five days. LTH proved to be an instance of associative memory and showed...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Romano, Arturo Gabriel, Tomsic, Daniel
Publicado: 1997
Materias:
Angiotensin
Cycloheximide
Massed training
Memory
PKA
Spaced training
Chasmagnathus
Decapoda (Crustacea)
Iti
animal
animal behavior
biological model
Brachyura
habituation
memory
physiology
review
Animals
Behavior, Animal
Habituation, Psychophysiologic
Models, Biological
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0100879X_v30_n7_p813_Maldonado
http://hdl.handle.net/20.500.12110/paper_0100879X_v30_n7_p813_Maldonado
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_0100879X_v30_n7_p813_Maldonado
record_format dspace
spelling paper:paper_0100879X_v30_n7_p813_Maldonado2023-06-08T15:10:15Z Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory Romano, Arturo Gabriel Tomsic, Daniel Angiotensin Cycloheximide Massed training Memory PKA Spaced training Chasmagnathus Decapoda (Crustacea) Iti animal animal behavior biological model Brachyura habituation memory physiology review Animals Behavior, Animal Brachyura Habituation, Psychophysiologic Memory Models, Biological A decade of studies on long-term habituation (LTH) in the crab Chasmagnathus is reviewed. Upon sudden presentation of a passing object overhead, the crab reacts with an escape response that habituates promptly and for at least five days. LTH proved to be an instance of associative memory and showed context, stimulus frequency and circadian phase specificity. A strong training protocol (STP) (≥15 trials, intertriai interval (ITI) of 171 s) invariably yielded LTH, while a weak training protocol (WTP) (≤10 trials, ITI = 171 s) invariably failed. STP was used with a presumably amnestic agent and WTP with a presumably hypermnestic agent. Remarkably, systemic administration of low doses was effective, which is likely to be due to the lack of an endothelial blood-brain barrier. LTH was blocked by inhibitors of protein and RNA synthesis, enhanced by protein kinase A (PKA) activators and reduced by PKA inhibitors, facilitated by angiotensin II and IV and disrupted by saralasin. The presence of angiotensins and related compounds in the crab brain was demonstrated. Diverse results suggest that LTH includes two components: an initial memory produced by spaced training and mainly expressed at an initial phase of testing, and a retraining memory produced by massed training and expressed at a later phase of testing (retraining). The initial memory would be associative, context specific and sensitive to cycloheximide, while the retraining memory would be nonassociative, context independent and insensitive to cycloheximide. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Tomsic, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1997 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0100879X_v30_n7_p813_Maldonado http://hdl.handle.net/20.500.12110/paper_0100879X_v30_n7_p813_Maldonado
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Angiotensin
Cycloheximide
Massed training
Memory
PKA
Spaced training
Chasmagnathus
Decapoda (Crustacea)
Iti
animal
animal behavior
biological model
Brachyura
habituation
memory
physiology
review
Animals
Behavior, Animal
Brachyura
Habituation, Psychophysiologic
Memory
Models, Biological
spellingShingle Angiotensin
Cycloheximide
Massed training
Memory
PKA
Spaced training
Chasmagnathus
Decapoda (Crustacea)
Iti
animal
animal behavior
biological model
Brachyura
habituation
memory
physiology
review
Animals
Behavior, Animal
Brachyura
Habituation, Psychophysiologic
Memory
Models, Biological
Romano, Arturo Gabriel
Tomsic, Daniel
Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory
topic_facet Angiotensin
Cycloheximide
Massed training
Memory
PKA
Spaced training
Chasmagnathus
Decapoda (Crustacea)
Iti
animal
animal behavior
biological model
Brachyura
habituation
memory
physiology
review
Animals
Behavior, Animal
Brachyura
Habituation, Psychophysiologic
Memory
Models, Biological
description A decade of studies on long-term habituation (LTH) in the crab Chasmagnathus is reviewed. Upon sudden presentation of a passing object overhead, the crab reacts with an escape response that habituates promptly and for at least five days. LTH proved to be an instance of associative memory and showed context, stimulus frequency and circadian phase specificity. A strong training protocol (STP) (≥15 trials, intertriai interval (ITI) of 171 s) invariably yielded LTH, while a weak training protocol (WTP) (≤10 trials, ITI = 171 s) invariably failed. STP was used with a presumably amnestic agent and WTP with a presumably hypermnestic agent. Remarkably, systemic administration of low doses was effective, which is likely to be due to the lack of an endothelial blood-brain barrier. LTH was blocked by inhibitors of protein and RNA synthesis, enhanced by protein kinase A (PKA) activators and reduced by PKA inhibitors, facilitated by angiotensin II and IV and disrupted by saralasin. The presence of angiotensins and related compounds in the crab brain was demonstrated. Diverse results suggest that LTH includes two components: an initial memory produced by spaced training and mainly expressed at an initial phase of testing, and a retraining memory produced by massed training and expressed at a later phase of testing (retraining). The initial memory would be associative, context specific and sensitive to cycloheximide, while the retraining memory would be nonassociative, context independent and insensitive to cycloheximide.
author Romano, Arturo Gabriel
Tomsic, Daniel
author_facet Romano, Arturo Gabriel
Tomsic, Daniel
author_sort Romano, Arturo Gabriel
title Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory
title_short Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory
title_full Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory
title_fullStr Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory
title_full_unstemmed Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory
title_sort long-term habituation (lth) in the crab chasmagnathus: a model for behavioral and mechanistic studies of memory
publishDate 1997
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0100879X_v30_n7_p813_Maldonado
http://hdl.handle.net/20.500.12110/paper_0100879X_v30_n7_p813_Maldonado
work_keys_str_mv AT romanoarturogabriel longtermhabituationlthinthecrabchasmagnathusamodelforbehavioralandmechanisticstudiesofmemory
AT tomsicdaniel longtermhabituationlthinthecrabchasmagnathusamodelforbehavioralandmechanisticstudiesofmemory
_version_ 1768545367635263488

Ejemplares similares