Alpha adrenergic stimulation modified prostaglandins release in vas deferens
Methoxamine enhanced contractions of mouse vasa deferentia through alpha adrenoceptor stimulation. Additionally, the generation of PGF-like material by the tissue was increased by methoxamine, whereas that of PGE-like material was decreased. The effects of methoxamine on prostaglandin output (stimul...
Guardado en:
| Publicado: |
1983
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v26_n5_p701_Borda http://hdl.handle.net/20.500.12110/paper_00906980_v26_n5_p701_Borda |
| Aporte de: |
| id |
paper:paper_00906980_v26_n5_p701_Borda |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_00906980_v26_n5_p701_Borda2023-06-08T15:07:56Z Alpha adrenergic stimulation modified prostaglandins release in vas deferens acetylsalicylic acid alpha adrenergic receptor indometacin methoxamine phenoxybenzamine prostaglandin prostaglandin e2 prostaglandin f2 alpha trometamol yohimbine animal cell autonomic nervous system drug efficacy male genital system mouse nonhuman sympathetic nerve vas deferens Animal Aspirin Cyclooxygenase Inhibitors Indomethacin Male Methoxamine Mice Muscle Contraction Phenoxybenzamine Prostaglandins E Prostaglandins F Receptors, Adrenergic, alpha Support, Non-U.S. Gov't Vas Deferens Yohimbine Methoxamine enhanced contractions of mouse vasa deferentia through alpha adrenoceptor stimulation. Additionally, the generation of PGF-like material by the tissue was increased by methoxamine, whereas that of PGE-like material was decreased. The effects of methoxamine on prostaglandin output (stimulation and depression) were antagonized by yohimbine and phenoxybenzamine. Moreover, the stimulating influence of methoxamine on the contractile activity of the preparations was attenuated by the prostaglandin synthesis inhibitors indomethacin and acetylsalicylic acid. The results suggest that methoxamine is able to modify prostaglandin synthesis and output in mouse vasa deferentia, probably through an alpha adrenergic mediated mechanism coupled to the prostaglandin synthesizing system. The fact that indomethacin and acetylsalicylic acid blocked alpha stimulatory responses to methoxamine, suggest a modulatory role for endogenous prostaglandins. Since methoxamine increased PGF levels, this prostaglandin might potentiate the contractile influence of methoxamine. © 1983. 1983 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v26_n5_p701_Borda http://hdl.handle.net/20.500.12110/paper_00906980_v26_n5_p701_Borda |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
acetylsalicylic acid alpha adrenergic receptor indometacin methoxamine phenoxybenzamine prostaglandin prostaglandin e2 prostaglandin f2 alpha trometamol yohimbine animal cell autonomic nervous system drug efficacy male genital system mouse nonhuman sympathetic nerve vas deferens Animal Aspirin Cyclooxygenase Inhibitors Indomethacin Male Methoxamine Mice Muscle Contraction Phenoxybenzamine Prostaglandins E Prostaglandins F Receptors, Adrenergic, alpha Support, Non-U.S. Gov't Vas Deferens Yohimbine |
| spellingShingle |
acetylsalicylic acid alpha adrenergic receptor indometacin methoxamine phenoxybenzamine prostaglandin prostaglandin e2 prostaglandin f2 alpha trometamol yohimbine animal cell autonomic nervous system drug efficacy male genital system mouse nonhuman sympathetic nerve vas deferens Animal Aspirin Cyclooxygenase Inhibitors Indomethacin Male Methoxamine Mice Muscle Contraction Phenoxybenzamine Prostaglandins E Prostaglandins F Receptors, Adrenergic, alpha Support, Non-U.S. Gov't Vas Deferens Yohimbine Alpha adrenergic stimulation modified prostaglandins release in vas deferens |
| topic_facet |
acetylsalicylic acid alpha adrenergic receptor indometacin methoxamine phenoxybenzamine prostaglandin prostaglandin e2 prostaglandin f2 alpha trometamol yohimbine animal cell autonomic nervous system drug efficacy male genital system mouse nonhuman sympathetic nerve vas deferens Animal Aspirin Cyclooxygenase Inhibitors Indomethacin Male Methoxamine Mice Muscle Contraction Phenoxybenzamine Prostaglandins E Prostaglandins F Receptors, Adrenergic, alpha Support, Non-U.S. Gov't Vas Deferens Yohimbine |
| description |
Methoxamine enhanced contractions of mouse vasa deferentia through alpha adrenoceptor stimulation. Additionally, the generation of PGF-like material by the tissue was increased by methoxamine, whereas that of PGE-like material was decreased. The effects of methoxamine on prostaglandin output (stimulation and depression) were antagonized by yohimbine and phenoxybenzamine. Moreover, the stimulating influence of methoxamine on the contractile activity of the preparations was attenuated by the prostaglandin synthesis inhibitors indomethacin and acetylsalicylic acid. The results suggest that methoxamine is able to modify prostaglandin synthesis and output in mouse vasa deferentia, probably through an alpha adrenergic mediated mechanism coupled to the prostaglandin synthesizing system. The fact that indomethacin and acetylsalicylic acid blocked alpha stimulatory responses to methoxamine, suggest a modulatory role for endogenous prostaglandins. Since methoxamine increased PGF levels, this prostaglandin might potentiate the contractile influence of methoxamine. © 1983. |
| title |
Alpha adrenergic stimulation modified prostaglandins release in vas deferens |
| title_short |
Alpha adrenergic stimulation modified prostaglandins release in vas deferens |
| title_full |
Alpha adrenergic stimulation modified prostaglandins release in vas deferens |
| title_fullStr |
Alpha adrenergic stimulation modified prostaglandins release in vas deferens |
| title_full_unstemmed |
Alpha adrenergic stimulation modified prostaglandins release in vas deferens |
| title_sort |
alpha adrenergic stimulation modified prostaglandins release in vas deferens |
| publishDate |
1983 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v26_n5_p701_Borda http://hdl.handle.net/20.500.12110/paper_00906980_v26_n5_p701_Borda |
| _version_ |
1768543172791631872 |