Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms
The effects of a wide range of PGE1 and PGE2 concentrations on the isometric developed tension of isolated rat atria beating spontaneously or paced at a fixed rate, were explored. PGE1 only produced a negative inotropic effect (NIE), whereas PGE2 elicited a biphasic inotropic action; negative at low...
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1980
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v20_n5_p825_SterinBorda http://hdl.handle.net/20.500.12110/paper_00906980_v20_n5_p825_SterinBorda |
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paper:paper_00906980_v20_n5_p825_SterinBorda2023-06-08T15:07:54Z Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms Adrenergic alpha Agonists Adrenergic beta Agonists alpha adrenergic receptor stimulating agent beta adrenergic receptor stimulating agent methoxamine noradrenalin prostaglandin E methoxamine noradrenalin phenoxybenzamine phentolamine propranolol prostaglandin E1 prostaglandin E2 animal article dose response drug effect heart atrium heart contraction in vitro study male rat adrenergic system animal experiment autonomic nervous system drug comparison heart heart atrium heart atrium contraction heart contraction heart inotropic effect inotropism isolated heart preliminary communication Adrenergic alpha-Agonists Adrenergic beta-Agonists Animal Dose-Response Relationship, Drug Heart Atrium In Vitro Male Methoxamine Myocardial Contraction Norepinephrine Prostaglandins E Rats Support, Non-U.S. Gov't Animalia The effects of a wide range of PGE1 and PGE2 concentrations on the isometric developed tension of isolated rat atria beating spontaneously or paced at a fixed rate, were explored. PGE1 only produced a negative inotropic effect (NIE), whereas PGE2 elicited a biphasic inotropic action; negative at low concentrations and positive (PIE) at higher ones. Phenoxybenzamine and phentolamine failed to modify either the NIE or the PIE, but subthreshold exogenous norepinephrine abolished the NIE, suggesting a presynaptic inhibitory effect of PGEs on the adrenergic neurotransmitter release. Auricles pretreated with subthreshold norepinephrine react with a PIE to PGE1, but not to PGE2. On the contrary in the presence of subthreshold methoxamine the PIE of PGE2 was increased whereas the action of PGE1 was not modified. © 1980, All rights reserved. 1980 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v20_n5_p825_SterinBorda http://hdl.handle.net/20.500.12110/paper_00906980_v20_n5_p825_SterinBorda |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Adrenergic alpha Agonists Adrenergic beta Agonists alpha adrenergic receptor stimulating agent beta adrenergic receptor stimulating agent methoxamine noradrenalin prostaglandin E methoxamine noradrenalin phenoxybenzamine phentolamine propranolol prostaglandin E1 prostaglandin E2 animal article dose response drug effect heart atrium heart contraction in vitro study male rat adrenergic system animal experiment autonomic nervous system drug comparison heart heart atrium heart atrium contraction heart contraction heart inotropic effect inotropism isolated heart preliminary communication Adrenergic alpha-Agonists Adrenergic beta-Agonists Animal Dose-Response Relationship, Drug Heart Atrium In Vitro Male Methoxamine Myocardial Contraction Norepinephrine Prostaglandins E Rats Support, Non-U.S. Gov't Animalia |
spellingShingle |
Adrenergic alpha Agonists Adrenergic beta Agonists alpha adrenergic receptor stimulating agent beta adrenergic receptor stimulating agent methoxamine noradrenalin prostaglandin E methoxamine noradrenalin phenoxybenzamine phentolamine propranolol prostaglandin E1 prostaglandin E2 animal article dose response drug effect heart atrium heart contraction in vitro study male rat adrenergic system animal experiment autonomic nervous system drug comparison heart heart atrium heart atrium contraction heart contraction heart inotropic effect inotropism isolated heart preliminary communication Adrenergic alpha-Agonists Adrenergic beta-Agonists Animal Dose-Response Relationship, Drug Heart Atrium In Vitro Male Methoxamine Myocardial Contraction Norepinephrine Prostaglandins E Rats Support, Non-U.S. Gov't Animalia Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms |
topic_facet |
Adrenergic alpha Agonists Adrenergic beta Agonists alpha adrenergic receptor stimulating agent beta adrenergic receptor stimulating agent methoxamine noradrenalin prostaglandin E methoxamine noradrenalin phenoxybenzamine phentolamine propranolol prostaglandin E1 prostaglandin E2 animal article dose response drug effect heart atrium heart contraction in vitro study male rat adrenergic system animal experiment autonomic nervous system drug comparison heart heart atrium heart atrium contraction heart contraction heart inotropic effect inotropism isolated heart preliminary communication Adrenergic alpha-Agonists Adrenergic beta-Agonists Animal Dose-Response Relationship, Drug Heart Atrium In Vitro Male Methoxamine Myocardial Contraction Norepinephrine Prostaglandins E Rats Support, Non-U.S. Gov't Animalia |
description |
The effects of a wide range of PGE1 and PGE2 concentrations on the isometric developed tension of isolated rat atria beating spontaneously or paced at a fixed rate, were explored. PGE1 only produced a negative inotropic effect (NIE), whereas PGE2 elicited a biphasic inotropic action; negative at low concentrations and positive (PIE) at higher ones. Phenoxybenzamine and phentolamine failed to modify either the NIE or the PIE, but subthreshold exogenous norepinephrine abolished the NIE, suggesting a presynaptic inhibitory effect of PGEs on the adrenergic neurotransmitter release. Auricles pretreated with subthreshold norepinephrine react with a PIE to PGE1, but not to PGE2. On the contrary in the presence of subthreshold methoxamine the PIE of PGE2 was increased whereas the action of PGE1 was not modified. © 1980, All rights reserved. |
title |
Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms |
title_short |
Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms |
title_full |
Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms |
title_fullStr |
Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms |
title_full_unstemmed |
Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms |
title_sort |
inotropic effect of pge1 and pge2 on isolated rat atria. influence of adrenergic mechanisms |
publishDate |
1980 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v20_n5_p825_SterinBorda http://hdl.handle.net/20.500.12110/paper_00906980_v20_n5_p825_SterinBorda |
_version_ |
1768545411986882560 |