Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases

Highly sophisticated mechanisms confer upon the immune system the capacity to respond with a certain degree of autonomy. However, the final outcome of an adaptative immune response depends on the interaction with other systems of the organism. The immune-neuroendocrine systems have an intimate cross...

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Autores principales:	Druker, Jimena Paola, Liberman, Ana, Giacomini, Damiana Paula, Refojo, Damián, Silberstein Cuña, Susana Iris, Páez Pereda, Marcelo
Publicado:	2006
Materias:	Apoptosis BMP-4 cAMP Estrogens GATA-3 Glucocorticoids Prolactinoma T-bet TCR TGF-β Th1-Th2 differentiation cytokine estrogen receptor glucocorticoid receptor steroid hormone transcription factor transforming growth factor beta steroid apoptosis cell differentiation conference paper gene activation gene repression helper cell immune response neuroendocrine system pathogenesis protein interaction signal transduction T lymphocyte human immunology immunomodulation metabolism neurosecretion review Cytokines Humans Neuroimmunomodulation Neurosecretory Systems Steroids
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v1088_n_p297_Druker http://hdl.handle.net/20.500.12110/paper_00778923_v1088_n_p297_Druker
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00778923_v1088_n_p297_Druker
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spelling	paper:paper_00778923_v1088_n_p297_Druker2023-06-08T15:07:27Z Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases Druker, Jimena Paola Liberman, Ana Giacomini, Damiana Paula Refojo, Damián Silberstein Cuña, Susana Iris Páez Pereda, Marcelo Apoptosis BMP-4 cAMP Estrogens GATA-3 Glucocorticoids Prolactinoma T-bet TCR TGF-β Th1-Th2 differentiation cytokine estrogen receptor glucocorticoid receptor steroid hormone transcription factor transforming growth factor beta cytokine steroid apoptosis cell differentiation conference paper gene activation gene repression helper cell immune response neuroendocrine system pathogenesis protein interaction signal transduction T lymphocyte human immunology immunomodulation metabolism neurosecretion review Cytokines Humans Neuroimmunomodulation Neurosecretory Systems Steroids Highly sophisticated mechanisms confer upon the immune system the capacity to respond with a certain degree of autonomy. However, the final outcome of an adaptative immune response depends on the interaction with other systems of the organism. The immune-neuroendocrine systems have an intimate cross-communication, making possible a satisfactory response to environmental changes. Part of this interaction occurs through cytokines and steroid hormones. The last step of this crosstalk is at the molecular level. In this article we will focus on the physical and functional interrelationship between cytokine signaling pathway-activated transcription factors (TFs) and steroid receptors in different cell models, where the signals triggered by cytokines and steroid hormones have major roles: (1) the ligand-dependent-activated glucocorticoid receptor (GR) influence the genetic program that specifies lineage commitment in T helper (Th) cell differentiation. How posttranslational modifications of several TFs as well as nuclear hormone receptors could be implicated in the molecular crosstalk between the immune-neuroendocrine messengers is discussed. (2) glucocorticoid (GC) antagonism on the TCR-induced T cell apoptosis. (3) estrogen receptor/TGF-β family proteins molecular interaction implicated on pituitary prolactinomas pathogenesis. The functional crosstalk at the molecular level between immune and steroids signals is essential to determine an integrative response to both mediators (which in the last instance results in a new gene activation/repression profile) and constitutes the ultimate integrative level of interaction between the immune and neuroendocrine systems. © 2006 New York Academy of Sciences. Fil:Druker, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Liberman, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Giacomini, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Refojo, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Silberstein, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pereda, M.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2006 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v1088_n_p297_Druker http://hdl.handle.net/20.500.12110/paper_00778923_v1088_n_p297_Druker
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Apoptosis BMP-4 cAMP Estrogens GATA-3 Glucocorticoids Prolactinoma T-bet TCR TGF-β Th1-Th2 differentiation cytokine estrogen receptor glucocorticoid receptor steroid hormone transcription factor transforming growth factor beta cytokine steroid apoptosis cell differentiation conference paper gene activation gene repression helper cell immune response neuroendocrine system pathogenesis protein interaction signal transduction T lymphocyte human immunology immunomodulation metabolism neurosecretion review Cytokines Humans Neuroimmunomodulation Neurosecretory Systems Steroids
spellingShingle	Apoptosis BMP-4 cAMP Estrogens GATA-3 Glucocorticoids Prolactinoma T-bet TCR TGF-β Th1-Th2 differentiation cytokine estrogen receptor glucocorticoid receptor steroid hormone transcription factor transforming growth factor beta cytokine steroid apoptosis cell differentiation conference paper gene activation gene repression helper cell immune response neuroendocrine system pathogenesis protein interaction signal transduction T lymphocyte human immunology immunomodulation metabolism neurosecretion review Cytokines Humans Neuroimmunomodulation Neurosecretory Systems Steroids Druker, Jimena Paola Liberman, Ana Giacomini, Damiana Paula Refojo, Damián Silberstein Cuña, Susana Iris Páez Pereda, Marcelo Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases
topic_facet	Apoptosis BMP-4 cAMP Estrogens GATA-3 Glucocorticoids Prolactinoma T-bet TCR TGF-β Th1-Th2 differentiation cytokine estrogen receptor glucocorticoid receptor steroid hormone transcription factor transforming growth factor beta cytokine steroid apoptosis cell differentiation conference paper gene activation gene repression helper cell immune response neuroendocrine system pathogenesis protein interaction signal transduction T lymphocyte human immunology immunomodulation metabolism neurosecretion review Cytokines Humans Neuroimmunomodulation Neurosecretory Systems Steroids
description	Highly sophisticated mechanisms confer upon the immune system the capacity to respond with a certain degree of autonomy. However, the final outcome of an adaptative immune response depends on the interaction with other systems of the organism. The immune-neuroendocrine systems have an intimate cross-communication, making possible a satisfactory response to environmental changes. Part of this interaction occurs through cytokines and steroid hormones. The last step of this crosstalk is at the molecular level. In this article we will focus on the physical and functional interrelationship between cytokine signaling pathway-activated transcription factors (TFs) and steroid receptors in different cell models, where the signals triggered by cytokines and steroid hormones have major roles: (1) the ligand-dependent-activated glucocorticoid receptor (GR) influence the genetic program that specifies lineage commitment in T helper (Th) cell differentiation. How posttranslational modifications of several TFs as well as nuclear hormone receptors could be implicated in the molecular crosstalk between the immune-neuroendocrine messengers is discussed. (2) glucocorticoid (GC) antagonism on the TCR-induced T cell apoptosis. (3) estrogen receptor/TGF-β family proteins molecular interaction implicated on pituitary prolactinomas pathogenesis. The functional crosstalk at the molecular level between immune and steroids signals is essential to determine an integrative response to both mediators (which in the last instance results in a new gene activation/repression profile) and constitutes the ultimate integrative level of interaction between the immune and neuroendocrine systems. © 2006 New York Academy of Sciences.
author	Druker, Jimena Paola Liberman, Ana Giacomini, Damiana Paula Refojo, Damián Silberstein Cuña, Susana Iris Páez Pereda, Marcelo
author_facet	Druker, Jimena Paola Liberman, Ana Giacomini, Damiana Paula Refojo, Damián Silberstein Cuña, Susana Iris Páez Pereda, Marcelo
author_sort	Druker, Jimena Paola
title	Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases
title_short	Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases
title_full	Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases
title_fullStr	Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases
title_full_unstemmed	Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases
title_sort	molecular understanding of cytokine-steroid hormone dialogue: implications for human diseases
publishDate	2006
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v1088_n_p297_Druker http://hdl.handle.net/20.500.12110/paper_00778923_v1088_n_p297_Druker
work_keys_str_mv	AT drukerjimenapaola molecularunderstandingofcytokinesteroidhormonedialogueimplicationsforhumandiseases AT libermanana molecularunderstandingofcytokinesteroidhormonedialogueimplicationsforhumandiseases AT giacominidamianapaula molecularunderstandingofcytokinesteroidhormonedialogueimplicationsforhumandiseases AT refojodamian molecularunderstandingofcytokinesteroidhormonedialogueimplicationsforhumandiseases AT silbersteincunasusanairis molecularunderstandingofcytokinesteroidhormonedialogueimplicationsforhumandiseases AT paezperedamarcelo molecularunderstandingofcytokinesteroidhormonedialogueimplicationsforhumandiseases
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Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases

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