Multiple functional targets of the immunoregulatory activity of Galectin-1. Control of immune cell trafficking, dendritic cell physiology, and T-cell fate
In the postgenomic era, the study of the glycome-the whole repertoire of saccharides in cells and tissues-has enabled the association of unique glycan structures with specific physiological and pathological processes. The responsibility for deciphering this biological information belongs to endogeno...
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paper:paper_00766879_v480_nC_p199_Cooper2023-06-08T15:07:22Z Multiple functional targets of the immunoregulatory activity of Galectin-1. Control of immune cell trafficking, dendritic cell physiology, and T-cell fate Ilarregui, Juan Martín Croci Russo, Diego Omar Dendritic cells Galectin-1 Glycoimmunology Homeostasis Inflammation Neutrophils T cells Tolerance Trafficking galectin 1 adoptive transfer antiinflammatory activity article autoimmune disease binding assay carbohydrate analysis cell count cell culture cell death cell differentiation cell fate cell function cell isolation cell maturation cell migration cell polarity cell surface cell survival chemotaxis conceptual framework cremaster muscle dendritic cell disease model endocytosis endothelium cell helper cell homeostasis human immunological tolerance immunoregulation leukocyte mesentery microvasculature mother fetus relationship nonhuman peritonitis phenotype priority journal protein function quantitative analysis real time polymerase chain reaction regulatory mechanism T lymphocyte Th1 cell Th17 cell Th2 cell Western blotting Animals Chemotaxis, Leukocyte Dendritic Cells Galectin 1 Humans Immune System Immunomodulation Laboratory Techniques and Procedures Models, Biological T-Lymphocytes In the postgenomic era, the study of the glycome-the whole repertoire of saccharides in cells and tissues-has enabled the association of unique glycan structures with specific physiological and pathological processes. The responsibility for deciphering this biological information belongs to endogenous glycan-binding proteins or lectins. Galectin-1, a prototypic member of a family of structurally related proteins, has demonstrated selective antiinflammatory and immunoregulatory effects either by controlling immune cell trafficking, "fine-tuning" dendritic cell physiology and regulating T-cell fate. These regulatory functions mediated by an endogenous glycan-binding protein may contribute to fulfill the needs for immune cell homeostasis, including preservation of fetomaternal tolerance and prevention of collateral damage as a result of microbial invasion or autoimmune pathology. We will discuss here the conceptual framework which led to the study of galectin-glycan lattices as a novel paradigm of immune cell communication in physiological and pathological processes and will highlight selected methods and experimental strategies which have contributed to the study of the immunoregulatory activities of this multifaceted glycan-binding protein both in in vitro and in vivo biological settings. © 2010 Elsevier Inc. Fil:Ilarregui, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Croci, D.O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00766879_v480_nC_p199_Cooper http://hdl.handle.net/20.500.12110/paper_00766879_v480_nC_p199_Cooper |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Dendritic cells Galectin-1 Glycoimmunology Homeostasis Inflammation Neutrophils T cells Tolerance Trafficking galectin 1 adoptive transfer antiinflammatory activity article autoimmune disease binding assay carbohydrate analysis cell count cell culture cell death cell differentiation cell fate cell function cell isolation cell maturation cell migration cell polarity cell surface cell survival chemotaxis conceptual framework cremaster muscle dendritic cell disease model endocytosis endothelium cell helper cell homeostasis human immunological tolerance immunoregulation leukocyte mesentery microvasculature mother fetus relationship nonhuman peritonitis phenotype priority journal protein function quantitative analysis real time polymerase chain reaction regulatory mechanism T lymphocyte Th1 cell Th17 cell Th2 cell Western blotting Animals Chemotaxis, Leukocyte Dendritic Cells Galectin 1 Humans Immune System Immunomodulation Laboratory Techniques and Procedures Models, Biological T-Lymphocytes |
| spellingShingle |
Dendritic cells Galectin-1 Glycoimmunology Homeostasis Inflammation Neutrophils T cells Tolerance Trafficking galectin 1 adoptive transfer antiinflammatory activity article autoimmune disease binding assay carbohydrate analysis cell count cell culture cell death cell differentiation cell fate cell function cell isolation cell maturation cell migration cell polarity cell surface cell survival chemotaxis conceptual framework cremaster muscle dendritic cell disease model endocytosis endothelium cell helper cell homeostasis human immunological tolerance immunoregulation leukocyte mesentery microvasculature mother fetus relationship nonhuman peritonitis phenotype priority journal protein function quantitative analysis real time polymerase chain reaction regulatory mechanism T lymphocyte Th1 cell Th17 cell Th2 cell Western blotting Animals Chemotaxis, Leukocyte Dendritic Cells Galectin 1 Humans Immune System Immunomodulation Laboratory Techniques and Procedures Models, Biological T-Lymphocytes Ilarregui, Juan Martín Croci Russo, Diego Omar Multiple functional targets of the immunoregulatory activity of Galectin-1. Control of immune cell trafficking, dendritic cell physiology, and T-cell fate |
| topic_facet |
Dendritic cells Galectin-1 Glycoimmunology Homeostasis Inflammation Neutrophils T cells Tolerance Trafficking galectin 1 adoptive transfer antiinflammatory activity article autoimmune disease binding assay carbohydrate analysis cell count cell culture cell death cell differentiation cell fate cell function cell isolation cell maturation cell migration cell polarity cell surface cell survival chemotaxis conceptual framework cremaster muscle dendritic cell disease model endocytosis endothelium cell helper cell homeostasis human immunological tolerance immunoregulation leukocyte mesentery microvasculature mother fetus relationship nonhuman peritonitis phenotype priority journal protein function quantitative analysis real time polymerase chain reaction regulatory mechanism T lymphocyte Th1 cell Th17 cell Th2 cell Western blotting Animals Chemotaxis, Leukocyte Dendritic Cells Galectin 1 Humans Immune System Immunomodulation Laboratory Techniques and Procedures Models, Biological T-Lymphocytes |
| description |
In the postgenomic era, the study of the glycome-the whole repertoire of saccharides in cells and tissues-has enabled the association of unique glycan structures with specific physiological and pathological processes. The responsibility for deciphering this biological information belongs to endogenous glycan-binding proteins or lectins. Galectin-1, a prototypic member of a family of structurally related proteins, has demonstrated selective antiinflammatory and immunoregulatory effects either by controlling immune cell trafficking, "fine-tuning" dendritic cell physiology and regulating T-cell fate. These regulatory functions mediated by an endogenous glycan-binding protein may contribute to fulfill the needs for immune cell homeostasis, including preservation of fetomaternal tolerance and prevention of collateral damage as a result of microbial invasion or autoimmune pathology. We will discuss here the conceptual framework which led to the study of galectin-glycan lattices as a novel paradigm of immune cell communication in physiological and pathological processes and will highlight selected methods and experimental strategies which have contributed to the study of the immunoregulatory activities of this multifaceted glycan-binding protein both in in vitro and in vivo biological settings. © 2010 Elsevier Inc. |
| author |
Ilarregui, Juan Martín Croci Russo, Diego Omar |
| author_facet |
Ilarregui, Juan Martín Croci Russo, Diego Omar |
| author_sort |
Ilarregui, Juan Martín |
| title |
Multiple functional targets of the immunoregulatory activity of Galectin-1. Control of immune cell trafficking, dendritic cell physiology, and T-cell fate |
| title_short |
Multiple functional targets of the immunoregulatory activity of Galectin-1. Control of immune cell trafficking, dendritic cell physiology, and T-cell fate |
| title_full |
Multiple functional targets of the immunoregulatory activity of Galectin-1. Control of immune cell trafficking, dendritic cell physiology, and T-cell fate |
| title_fullStr |
Multiple functional targets of the immunoregulatory activity of Galectin-1. Control of immune cell trafficking, dendritic cell physiology, and T-cell fate |
| title_full_unstemmed |
Multiple functional targets of the immunoregulatory activity of Galectin-1. Control of immune cell trafficking, dendritic cell physiology, and T-cell fate |
| title_sort |
multiple functional targets of the immunoregulatory activity of galectin-1. control of immune cell trafficking, dendritic cell physiology, and t-cell fate |
| publishDate |
2010 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00766879_v480_nC_p199_Cooper http://hdl.handle.net/20.500.12110/paper_00766879_v480_nC_p199_Cooper |
| work_keys_str_mv |
AT ilarreguijuanmartin multiplefunctionaltargetsoftheimmunoregulatoryactivityofgalectin1controlofimmunecelltraffickingdendriticcellphysiologyandtcellfate AT crocirussodiegoomar multiplefunctionaltargetsoftheimmunoregulatoryactivityofgalectin1controlofimmunecelltraffickingdendriticcellphysiologyandtcellfate |
| _version_ |
1768546390131081216 |