Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content...
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2003
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00664804_v47_n6_p2047_Urbina http://hdl.handle.net/20.500.12110/paper_00664804_v47_n6_p2047_Urbina |
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paper:paper_00664804_v47_n6_p2047_Urbina2023-06-08T15:06:10Z Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease Rodríguez, Juan Bautista 4 phenoxyphenoxyethyl thiocyanate antiprotozoal agent squalene synthase sterol unclassified drug wc 9 antiprotozoal activity article Chagas disease controlled study drug activity drug mechanism epimastigote growth inhibition nonhuman priority journal sterol synthesis Trypanosoma cruzi Alkyl and Aryl Transferases Animals Dose-Response Relationship, Drug Ergosterol Farnesyl-Diphosphate Farnesyltransferase Geranyltranstransferase Humans Microbial Sensitivity Tests Phenyl Ethers Thiocyanates Trypanocidal Agents Trypanosoma cruzi We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase. Fil:Rodriguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2003 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00664804_v47_n6_p2047_Urbina http://hdl.handle.net/20.500.12110/paper_00664804_v47_n6_p2047_Urbina |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
4 phenoxyphenoxyethyl thiocyanate antiprotozoal agent squalene synthase sterol unclassified drug wc 9 antiprotozoal activity article Chagas disease controlled study drug activity drug mechanism epimastigote growth inhibition nonhuman priority journal sterol synthesis Trypanosoma cruzi Alkyl and Aryl Transferases Animals Dose-Response Relationship, Drug Ergosterol Farnesyl-Diphosphate Farnesyltransferase Geranyltranstransferase Humans Microbial Sensitivity Tests Phenyl Ethers Thiocyanates Trypanocidal Agents Trypanosoma cruzi |
| spellingShingle |
4 phenoxyphenoxyethyl thiocyanate antiprotozoal agent squalene synthase sterol unclassified drug wc 9 antiprotozoal activity article Chagas disease controlled study drug activity drug mechanism epimastigote growth inhibition nonhuman priority journal sterol synthesis Trypanosoma cruzi Alkyl and Aryl Transferases Animals Dose-Response Relationship, Drug Ergosterol Farnesyl-Diphosphate Farnesyltransferase Geranyltranstransferase Humans Microbial Sensitivity Tests Phenyl Ethers Thiocyanates Trypanocidal Agents Trypanosoma cruzi Rodríguez, Juan Bautista Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease |
| topic_facet |
4 phenoxyphenoxyethyl thiocyanate antiprotozoal agent squalene synthase sterol unclassified drug wc 9 antiprotozoal activity article Chagas disease controlled study drug activity drug mechanism epimastigote growth inhibition nonhuman priority journal sterol synthesis Trypanosoma cruzi Alkyl and Aryl Transferases Animals Dose-Response Relationship, Drug Ergosterol Farnesyl-Diphosphate Farnesyltransferase Geranyltranstransferase Humans Microbial Sensitivity Tests Phenyl Ethers Thiocyanates Trypanocidal Agents Trypanosoma cruzi |
| description |
We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase. |
| author |
Rodríguez, Juan Bautista |
| author_facet |
Rodríguez, Juan Bautista |
| author_sort |
Rodríguez, Juan Bautista |
| title |
Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease |
| title_short |
Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease |
| title_full |
Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease |
| title_fullStr |
Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease |
| title_full_unstemmed |
Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease |
| title_sort |
mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (wc-9) against trypanosoma cruzi, the causative agent of chagas' disease |
| publishDate |
2003 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00664804_v47_n6_p2047_Urbina http://hdl.handle.net/20.500.12110/paper_00664804_v47_n6_p2047_Urbina |
| work_keys_str_mv |
AT rodriguezjuanbautista mechanismofactionof4phenoxyphenoxyethylthiocyanatewc9againsttrypanosomacruzithecausativeagentofchagasdisease |
| _version_ |
1768544903209418752 |